Boosting Vascular Imaging‐Performance and Systemic Biosafety of Ultra‐Small NaGdF<sub>4</sub> Nanoparticles via Surface Engineering with Rationally Designed Novel Hydrophilic Block Co‐Polymer

Jiang, Zhilin; Xia, Bin; Ren, Feng; Bao, Bolin; Xing, Wei; He, Tao; Li, Zhen

doi:10.1002/smtd.202101145

Cited by 4 publications

(1 citation statement)

References 77 publications

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“…The short t 1/2α suggests that Cu(II)/LRu/PDA NPs distribute fast, maybe due to the higher selectivity to target tissues. A long t 1/2β indicates that Cu(II)/LRu/PDA NPs, which possess a negatively charged surface, are metabolized slowly by repelling the attachment of most proteins with negative charges and avoiding the quick clearance by phagocytes. , The biodistribution of Cu(II)/LRu/PDA NPs in major organs was also evaluated in the same way. On days 1, 2, and 5 postinjection i.v., the major organs and tumors were obtained to test the Cu(II) content.…”

Section: Resultsmentioning

confidence: 99%

Copper Ion and Ruthenium Complex Codoped Polydopamine Nanoparticles for Magnetic Resonance/Photoacoustic Tomography Imaging-Guided Photodynamic/Photothermal Dual-Mode Therapy

Zhang

Wang

Liu

et al. 2022

ACS Appl. Bio Mater.

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Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT), refers to the therapeutic strategy using a visible or near-infrared (NIR) laser to generate free radicals or heat for noninvasive and localized tumor treatment. However, limited by the low photoconversion efficiency of therapeutic agents, a single treatment method can hardly lead to complete tumor ablation, even when enhancing the power density of the laser and/or prolonging the irradiation duration. In this work, copper ion and ruthenium complex codoped polydopamine nanoparticles (Cu(II)/LRu/PDA NPs) are designed for PDT/PTT dual-mode therapy. The doped LRu in the NPs can generate reactive oxygen species under visible laser irradiation and enable PDT. Because of the strong absorption in the NIR region, PDA can not only generate heat for PTT under irradiation but also be used for photoacoustic tomography (PAT) imaging. Meanwhile, the doping of Cu(II) in the NPs through the coordination with PDA facilitates T1-weighted magnetic resonance imaging (MRI). Thus, MR/PAT imaging-guided PDT/PTT dual-mode therapy is achieved. The in vivo experiments indicate that the Cu(II)/LRu/PDA NPs can accumulate in HeLa tumors with a retention rate up to 8.34%ID/g. MR/PAT imaging can clearly identify the location and boundary of the tumors, permitting precise guidance for phototherapy. Under the combined effect of PDT and PTT, a complete ablation of HeLa tumors is achieved. The current work provides an alternative nanoplatform for performing PDT/PTT dual-mode therapy, which can be further guided by MR/PAT imaging.

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Section: Resultsmentioning

confidence: 99%

Copper Ion and Ruthenium Complex Codoped Polydopamine Nanoparticles for Magnetic Resonance/Photoacoustic Tomography Imaging-Guided Photodynamic/Photothermal Dual-Mode Therapy

Zhang

Wang

Liu

et al. 2022

ACS Appl. Bio Mater.

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Targeted Immunoimaging of Tumor‐Associated Macrophages in Orthotopic Glioblastoma by the NIR‐IIb Nanoprobes

Zhu

Ren

Wang

et al. 2022

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Developing dynamic and highly sensitive methods for imaging M2‐type tumor‐associated macrophages (TAMs) is vital for monitoring the tumor progression and assessing the therapeutic efficacy. Here, the fabrication and application of rationally designed Er‐based rare‐earth nanoprobes for the targeted imaging of M2‐type TAMs in glioblastoma (GBM) through the second near‐infrared (NIR‐II) fluorescence beyond 1500 nm is reported. The NIR‐IIb fluorescence of Er‐based rare‐earth nanoparticles can be remarkably enhanced by optimizing their core‐shell structures and the shell thickness, which allows for in vivo imaging under excitation by a 980 nm laser with the lowest power density (40 mW cm‐2). These bright Er‐based nanoparticles functionalized with M2pep polypeptide show notable targeting ability to M2‐type macrophages, which has been well tested in both in vitro and in vivo experiments by their up‐conversion (UC) fluorescence (540 nm) and down‐shifting (DS) fluorescence (1525 nm), respectively. The targeting capability of these nanoprobes in vivo is also demonstrated by the overlap of immunofluorescence of M2‐type TAMs and Arsenazo III staining of rare‐earth ions in tumor tissue. It is envisioned that these nanoprobes can serve as a companion diagnostic tool to dynamically assess the progression and prognosis of GBM.

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Boosting luminescence and MRI evolution via regulation of GdPO4:5%Eu3+ morphologies by H3PO4

Wang

Yang

et al. 2023

Ceramics International

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Boosting Vascular Imaging‐Performance and Systemic Biosafety of Ultra‐Small NaGdF₄ Nanoparticles via Surface Engineering with Rationally Designed Novel Hydrophilic Block Co‐Polymer

Abstract: P-NMR spectra, which demonstrate that they have the same structure and the successful grafting of phosphate groups. GPC analysis demonstrates the monodisperse molecular weight distributions of BP n with different DPs (Figure 1c). Furthermore,

Cited by 4 publications

References 77 publications

Copper Ion and Ruthenium Complex Codoped Polydopamine Nanoparticles for Magnetic Resonance/Photoacoustic Tomography Imaging-Guided Photodynamic/Photothermal Dual-Mode Therapy

Copper Ion and Ruthenium Complex Codoped Polydopamine Nanoparticles for Magnetic Resonance/Photoacoustic Tomography Imaging-Guided Photodynamic/Photothermal Dual-Mode Therapy

Targeted Immunoimaging of Tumor‐Associated Macrophages in Orthotopic Glioblastoma by the NIR‐IIb Nanoprobes

Boosting luminescence and MRI evolution via regulation of GdPO4:5%Eu3+ morphologies by H3PO4

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Boosting Vascular Imaging‐Performance and Systemic Biosafety of Ultra‐Small NaGdF4 Nanoparticles via Surface Engineering with Rationally Designed Novel Hydrophilic Block Co‐Polymer

Abstract: P-NMR spectra, which demonstrate that they have the same structure and the successful grafting of phosphate groups. GPC analysis demonstrates the monodisperse molecular weight distributions of BP n with different DPs (Figure 1c). Furthermore,

Cited by 4 publications

References 77 publications

Copper Ion and Ruthenium Complex Codoped Polydopamine Nanoparticles for Magnetic Resonance/Photoacoustic Tomography Imaging-Guided Photodynamic/Photothermal Dual-Mode Therapy

Copper Ion and Ruthenium Complex Codoped Polydopamine Nanoparticles for Magnetic Resonance/Photoacoustic Tomography Imaging-Guided Photodynamic/Photothermal Dual-Mode Therapy

Targeted Immunoimaging of Tumor‐Associated Macrophages in Orthotopic Glioblastoma by the NIR‐IIb Nanoprobes

Boosting luminescence and MRI evolution via regulation of GdPO4:5%Eu3+ morphologies by H3PO4

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Boosting Vascular Imaging‐Performance and Systemic Biosafety of Ultra‐Small NaGdF₄ Nanoparticles via Surface Engineering with Rationally Designed Novel Hydrophilic Block Co‐Polymer