Boosting the peroxidase-like activity of Pt nanozymes by a synergistic effect of Ti₃C₂ nanosheets for dual mechanism detection

Abstract

Nanozymes show great promise in bioanalysis and therapeutics, which largely relies on high catalytic efficiency and selectivity. Inspired by the interfacial electronic interaction between noble metal and transition metal carbide,...

Peroxidase-like activity of hollow sphere-like FeS2/SC boosted by synergistic action of defects and S–C bonding

“…5A and C indicates a good linear relationship. K m and V max were calculated by eqn (1). The typical Michaelis-Menten model is shown in Fig.…”

“…Due to the high catalytic activity, low cost, easy storage, and high stability, nanoenzymes have attracted attention after the discovery of Fe 3 O 4 with similar activity to that of horseradish peroxidase (HRP). [1][2][3] Transition metal sulfides (TMSs) have been studied as nanozymes ( peroxidase) due to their easy preparation and low cost. [4][5][6][7][8] However, the low peroxidase-like (POD) activity induced a high concentration of H 2 O 2 to oxidize 3,3′,5,5′-tetramethylbenzidine (TMB, colorless) to oxTMB (blue).…”

MXene-based nanomaterials with enzyme-like properties for biomedical applications

“…Various metal nanoparticle/MXenes hybrids have also been reported, including Au/Ti 3 C 2 , 34,70–72 Pt/Ti 3 C 2 , 73 and Au–TiO 2 @Ti 2 C. 74 The in situ growth route was adopted by several groups for the synthesis of Au and Pt NPs on Ti 3 C 2 NSs, 34,70–73 via physical and chemical processes. For example, Tang et al 71 fabricated Ti 3 C 2 @Au-PEG nanocomposites through a seed-mediated growth method together with the surface modification of sulfhydryl polyethylene glycol (SH-PEG). By electrostatic adsorption, Wang et al 72 fabricated Ti 3 C 2 T x -supported Au NPs, which were prepared by liquid-phase reduction of the Au precursors in the presence of sodium citrate and sodium borohydride.…”

Nanozymes Based on MXene Nanosheets Decorated with Pt Nanoparticles for Hyperthermal-Enhanced Cascade Catalytic Therapy of Tumors

“…To achieve efficient catalytic therapy, improving the concentration of H 2 O 2 and enhancing catalytic activity are of particular importance. , MXene nanosheets are widely used in tumor PTT due to their excellent photothermal properties, while the large surface area of monolayer MXene nanosheets allows for easy modification and loading of nanoparticles. , Specially designed MXene composites loaded with nanozymes and multifunctional nanoparticles are being developed and employed in sensing detection . As reported previously, Ti 3 C 2 MXene can significantly enhance the POD-like activity of Pt nanozymes . NIR irradiation further specifically enhances the Ti 3 C 2 /Pt POD-like activity, which was attributed to a combination of the strong interfacial electronic effect of Ti 3 C 2 and photothermal effects.…”