Booster effect of canine distemper, canine parvovirus infection and infectious canine hepatitis combination vaccine in domesticated adult dogs

Taguchi, Masayuki; Namikawa, Kazuhiko; Maruo, Takuya; Orito, Kensuke; Lynch, Jonathan; Tsuchiya, Ryosuke; Sahara, Hiroeki

doi:10.1111/j.1348-0421.2012.00475.x

Cited by 5 publications

(10 citation statements)

References 13 publications

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“…Only 17.0 per cent of dogs receiving the CPV vaccine responded with an at least fourfold titre increase. These results confirm the findings of an earlier study (Taguchi and others 2012a) and underline that periodic CPV revaccination does not necessarily lead to a beneficial booster effect on the immune system. Low initial titre was identified as associated factor to vaccine booster effect, indicating that titre has to be low to allow the immune response to occur.…”

Section: Discussionsupporting

confidence: 92%

“…Recently, a Japanese study in domesticated adult dogs raised suspicion that booster vaccinations do commonly not result in a significant rise in CPV antibody titres even if prevaccination antibodies are low (Taguchi and others 2012a). Prevalence studies in the German dog population are missing, and there is only little knowledge about the benefit of booster vaccinations in dogs with pre-existing antibodies.…”

mentioning

confidence: 99%

“…According to previous studies, prevalence of CPV antibodies in the dog population varies significantly from 64 to 95 per cent (Tennant and others 1991, McCaw and others 1998, Twark and Dodds 2000, Böhm and others 2004, Ottiger and others 2006, Lechner and others 2010, Taguchi and others 2011, Litster and others 2012a). Recently, a Japanese study in domesticated adult dogs raised suspicion that booster vaccinations do commonly not result in a significant rise in CPV antibody titres even if prevaccination antibodies are low (Taguchi and others 2012a). Prevalence studies in the German dog population are missing, and there is only little knowledge about the benefit of booster vaccinations in dogs with pre‐existing antibodies.…”

mentioning

confidence: 99%

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Prevalence of antibodies to canine parvovirus and reaction to vaccination in client‐owned, healthy dogs

et al. 2015

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The purpose of this population-based cohort study was to assess current prevalence of antibodies to canine parvovirus (CPV) in adult, healthy dogs, including risk factors associated with lack of antibodies, and reaction to revaccination with a modified live vaccine (MLV). One hundred dogs routinely presented for vaccination were included in the study and vaccinated with a single dose of a combined MLV. Information was collected on signalment, origin, environment, vaccination history and side effects. Prevaccination and postvaccination antibodies were detected by haemagglutination inhibition. Univariate analysis, followed by multivariate logistic regression, was used to investigate association between different variables and presence of antibodies as well as titre increase. Protective CPV antibodies were present in 86.0 per cent of dogs. Intervals of more than four years since the last vaccination and rare contacts with other dogs were determined as main risk factors for the absence of antibodies. An increase in titres only occurred in 17.0 per cent of dogs. Dogs without protective titres before vaccination or with bodyweight <10 kg were more likely to have an adequate titre increase. Based on these findings, antibody status should be determined instead of periodic vaccinations to ensure reliable protection without unnecessary vaccinations in adult dogs.

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Section: Discussionsupporting

confidence: 92%

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confidence: 99%

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confidence: 99%

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Prevalence of antibodies to canine parvovirus and reaction to vaccination in client‐owned, healthy dogs

et al. 2015

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“…[16], and Tagushi et al . [17], a HI titer of ≥1:80 (equivalent to ≥1.9 GM log 10 HI titer) was enough to protect the pups against virulent challenge, whereas pups having HI titer of <1:40 (<1.6 GM log 10 HI titer) were fully susceptible (Figure-1). The pups having titer between 1:40 and 1:80 (1.6-1.9 GM log 10 HI titer) were considered partially protected.…”

Section: Resultsmentioning

confidence: 99%

“…This may be due to poor adherence of the vaccination schedule to be followed in dams by the canine breeders/owners in India in the absence of any strict regulations/guidelines. According to researchers such as Carmichael [5], Pratelli et al [16], and Tagushi et al [17], a HI titer of ≥1:80 (equivalent to ≥1.9 GM log 10 HI titer) was enough to protect the pups against virulent challenge, whereas pups having HI titer of <1:40 (<1.6 GM log 10 HI titer) were fully susceptible (Figure -1). The pups having titer between 1:40 and 1:80 (1.6-1.9 GM log 10 HI titer) were considered partially protected.…”

Section: Hi Testmentioning

confidence: 99%

Comparative immune responses of pups following modified live virus vaccinations against canine parvovirus

et al. 2019

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Background and Aim: Canine parvovirus (CPV) is the most important viral cause of enteritis and mortality in pups. Evaluation and monitoring of pre- and post-vaccine immune responses may help to determine the efficacy of the current vaccination schedule being followed in pups in India. This study aimed to evaluate and monitor the pre- and post-vaccine immune responses of CPV vaccinated pups using hemagglutination inhibition (HI) assay. The neutralizing antibody titer levels were also detected using serum neutralization test (SNT). Materials and Methods: The pups were categorized into two groups, the double booster and the single booster groups. In this study, serum samples were subjected to HI and SNT for measuring the CPV antibody titer at frequent intervals for up to 6 months from 27 healthy pups following primary and booster CPV vaccinations. Results: The antibody titers in double booster pups reached their peaks at the 21st day after the second booster vaccination with a geometric mean (GM) of 3.57. The antibody titers in single booster pups reached their peaks at the 21st day after the first booster vaccination with a lower GM of 3.18. Conclusion: The double booster pups maintained a higher immune response throughout the period of the study compared to single booster pups though the difference in titers was not statistically significant. SNT results indicated that the raised antibody titer was also able to yield virus-neutralizing antibodies. No interfering maternally derived antibodies were found in the pups at the age of primary vaccination (45th day) in our study. Therefore, the second booster vaccination may be useful in maintaining the protective titer for a prolonged period.

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A novel lateral flow immunochromatographic assay using a recombinant VP2 antigen for total antibody detection of canine parvovirus-2

Salmanli,

Tezcan,

Karaoglu

2024

Anal. Methods

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Booster effect of canine distemper, canine parvovirus infection and infectious canine hepatitis combination vaccine in domesticated adult dogs

Cited by 5 publications

References 13 publications

Prevalence of antibodies to canine parvovirus and reaction to vaccination in client‐owned, healthy dogs

Prevalence of antibodies to canine parvovirus and reaction to vaccination in client‐owned, healthy dogs

Comparative immune responses of pups following modified live virus vaccinations against canine parvovirus

A novel lateral flow immunochromatographic assay using a recombinant VP2 antigen for total antibody detection of canine parvovirus-2

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