Bone Tissue Condition during Osteosynthesis of a Femoral Shaft Fracture Using Biodegradable Magnesium Implants with an Anticorrosive Coating in Rats with Experimental Osteoporosis

Abstract

Today, osteoporosis has become a major global health issues. The World Health Organization declares that 320 billion people have osteoporosis now, and more than 1.5 billion osteoporosis traumatic events occur every year. Bones become fragile and fracture risk is high; thus, it is crucial to choose the right biodegradable implants in order to minimize reoperations of patients with systemic osteoporosis. This investigation aimed to carry out a morphological assessment of the state of bone tissue with osteosynthesis of a femoral fracture in rats, using a model of osteoporosis with the installation of magnesium alloy implants coated with hydroxyapatite and sealed with polytetrafluoroethylene. According to this study, the indicators of angiogenesis and bone formation in experimental animals were significantly higher when an implant coated with hydroxyapatite sealed with polytetrafluoroethylene was used, compared to an implant coated only with hydroxyapatite and in rats without an implant. Based on the data obtained, it is possible to consider a magnesium implant coated with hydroxyapatite and sealed with polytetrafluoroethylene as a promising material for fracture therapy in patients with reduced bone density.

In Silico Contact Pressure of Metal-on-Metal Total Hip Implant with Different Materials Subjected to Gait Loading

“…Second, geometric parameters are also important to investigate as described by Utomo et al [41] that these parameters may affect implant performance. Next, coating application in implant could minimize medical problems after hip replacement surgery which is in line with Maistrovskaia et al [42]. Surgical procedures also need to improve since technical issues have implications with failure as explained by London Health Sciences Centre [43] to improve the performance of metal-on-metal bearings in the future.…”

Histomorphometry and μCT scan analysis of osteoporosis in spayed female dogs

“…For the study of osteoporosis, scientists have used histopathological samples for many years, since this study method allows to comprehend the pathophysiology of the disease, draws conclusions, and prescribes the proper treatment or make other recommendations. However, after reviewing the scientific literature, we discovered that the study of osteoporosis in animals receives very little attention, while in humans, osteoporosis has been extensively studied, as it is considered a global disease ( Maistrovskaia et al ., 2022 ). In the scientific literature, animals are exclusively used as models for the study of human disease.…”

Tailoring Biotribological Performance of Polytetrafluoroethylene Nanocomposites through Control of Diameters and Aspect Ratios of In Situ Filled Hydroxyapatite Nanowires

“…Furthermore, a filling of nanosized HAP into PTFE will result in improved biocompatibility in addition to its excellent tribological performance of nanocomposites. [ 26–30 ]…”

“…Furthermore, a filling of nanosized HAP into PTFE will result in improved biocompatibility in addition to its excellent tribological performance of nanocomposites. [26][27][28][29][30] A variety of strategies were tried to prepare nanosized HAP such as hydrothermal synthesis, [17,31] coprecipitation, [32] sol-gel, [33] and reverse microemulsion-directed synthesis. [34] The resulting HAP nanowires (NWs) were found to possess extraordinary functions in mechanics and tribology with respect to the nanoparticles, nanosheets, and some hierarchical structures of HAP.…”