Bone tissue aging affects mineralization of cement lines

Milovanović, Petar; Scheidt, Annika vom; Mletzko, Kathrin; Sarau, George; Püschel, Klaus; Djurić, Marija; Amling, Michael; Christiansen, Silke; Busse, Björn

doi:10.1016/j.bone.2018.02.004

Cited by 44 publications

(34 citation statements)

References 52 publications

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“…b) Crack-initiation toughness values do not differ between the tested anatomical sites of the sword. [4,30,36,37] Thus, the mineralization analyses support the hypothesis that the rostrum is older at the tip than at the base. c) Lower crack-growth toughness was measured at the tip in comparison to the mid and base sections (*p < 0.01 by subset regression analysis, error bars represent the standard error of the fitting parameter).…”

Section: Discussionsupporting

confidence: 60%

“…[48] A lower degree of mineralization with a broad heterogeneous distribution can enable a high extent of crack deflection, and associated deformation, which promotes enhanced crack-growth resistance. [31] An increasing tissue mineralization with age has been shown to accompany a decreasing mineralization discrepancy between osteons and cement lines, [30] and this is one of the factors associated with the deterioration of the toughness of bone with aging. A prominent example of this is the mineralization discrepancy of cement line-like structures [16] to the neighboring osteon-like structures, which has been shown to be of crucial importance for crack deflection in bone.…”

Section: Discussionmentioning

confidence: 99%

“…[16] Aging and disease affect bone quality [4,7,20,[23][24][25] and can increase the risk of fracture. [26][27][28][29] Aging effects are strongly associated with reduced osteocyte viability and interconnection, [8,10,13] bone mineralization, [23,30] and decreased mechanical competence. [20] Increasing age, for example, decreases the interface mineralization discrepancy of cement lines and surrounding tissue, [30] a key factor for toughening.…”

Section: Introductionmentioning

confidence: 99%

“…[26][27][28][29] Aging effects are strongly associated with reduced osteocyte viability and interconnection, [8,10,13] bone mineralization, [23,30] and decreased mechanical competence. [20] Increasing age, for example, decreases the interface mineralization discrepancy of cement lines and surrounding tissue, [30] a key factor for toughening. [31] Lengthwise differences in bone quality can help to reveal the mechanistic material changes that counteract aging effects in bone.…”

Section: Introductionmentioning

confidence: 99%

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On the Origins of Fracture Toughness in Advanced Teleosts: How the Swordfish Sword's Bone Structure and Composition Allow for Slashing under Water to Kill or Stun Prey

et al. 2019

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The osseous sword of a swordfish ( Xiphias gladius ) is specialized to incapacitate prey with stunning blows. Considering the sword's growth and maturation pattern, aging from the sword's base to the tip, while missing a mechanosensitive osteocytic network, an in‐depth understanding of its mechanical properties and bone quality is lacking. Microstructural, compositional, and nanomechanical characteristics of the bone along the sword are investigated to reveal structural mechanisms accounting for its exceptional mechanical competence. The degree of mineralization, homogeneity, and particle size increase from the base toward the tip, reflecting aging along its length. Fracture experiments reveal that crack‐growth toughness vastly decreases at the highly and homogeneously mineralized tip, suggesting the importance of aging effects. Initiation toughness, however, is unchanged suggesting that aging effects on this hierarchical level are counteracted by constant mineral/fibril interaction. In conclusion, the sword of the swordfish provides an excellent model reflecting base‐to‐tip‐wise aging of bone, as indicated by increasing mineralization and decreasing crack‐growth toughness toward the tip. The hierarchical, structural, and compositional changes along the sword reflect peculiar prerequisites needed for resisting high mechanical loads. Further studies on advanced teleosts bone tissue may help to unravel structure–function relationships of heavily loaded skeletons lacking mechanosensing cells.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

On the Origins of Fracture Toughness in Advanced Teleosts: How the Swordfish Sword's Bone Structure and Composition Allow for Slashing under Water to Kill or Stun Prey

et al. 2019

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“…Subsequently, specimens were ground to 100 mm, and stained with toluidine blue [21]. Quantitative backscattered electron imaging (qBEI) was performed to assess the bone mineral density distribution (BMDD) as previously described [22][23][24]. Embedded incus and vertebral body specimens were polished and carbon coated for qBEI analyses.…”

Section: (D) Bone Preparation Histology and Quantitative Backscattermentioning

confidence: 99%

Ultra-high matrix mineralization of sperm whale auditory ossicles facilitates high sound pressure and high-frequency underwater hearing

et al. 2018

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Long-Term Immobilization in Elderly Females Causes a Specific Pattern of Cortical Bone and Osteocyte Deterioration Different From Postmenopausal Osteoporosis

Rolvien

Milovanović

Schmidt

et al. 2020

Journal of Bone and Mineral Research

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Immobilization as a result of long-term bed rest can lead to gradual bone loss. Because of their distribution throughout the bone matrix and remarkable interconnectivity, osteocytes represent the major mechanosensors in bone and translate mechanical into biochemical signals controlling bone remodeling. To test whether immobilization affects the characteristics of the osteocyte network in human cortical bone, femoral diaphyseal bone specimens were analyzed in immobilized female individuals and compared with agematched postmenopausal individuals with primary osteoporosis. Premenopausal and postmenopausal healthy individuals served as control groups. Cortical porosity, osteocyte number and lacunar area, the frequency of hypermineralized lacunae, as well as cortical bone calcium content (CaMean) were assessed using bone histomorphometry and quantitative backscattered electron imaging (qBEI). Bone matrix properties were further analyzed by Fourier transform infrared spectroscopy (FTIR). In the immobilization group, cortical porosity was significantly higher, and qBEI revealed a trend toward higher matrix mineralization compared with osteoporotic individuals. Osteocyte density and canalicular density showed a declining rate from premenopausal toward healthy postmenopausal and osteoporotic individuals with peculiar reductions in the immobilization group, whereas the number of hypermineralized lacunae accumulated inversely. In conclusion, reduced osteocyte density and impaired connectivity during immobilization are associated with a specific bone loss pattern, reflecting a phenotype clearly distinguishable from postmenopausal osteoporosis. Immobilization periods may lead to a loss of survival signals for osteocytes, provoking bone loss that is even higher than in osteoporosis states, whereas osteocytic osteolysis remains absent.

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Bone tissue aging affects mineralization of cement lines

Cited by 44 publications

References 52 publications

On the Origins of Fracture Toughness in Advanced Teleosts: How the Swordfish Sword's Bone Structure and Composition Allow for Slashing under Water to Kill or Stun Prey

On the Origins of Fracture Toughness in Advanced Teleosts: How the Swordfish Sword's Bone Structure and Composition Allow for Slashing under Water to Kill or Stun Prey

Ultra-high matrix mineralization of sperm whale auditory ossicles facilitates high sound pressure and high-frequency underwater hearing

Long-Term Immobilization in Elderly Females Causes a Specific Pattern of Cortical Bone and Osteocyte Deterioration Different From Postmenopausal Osteoporosis

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