Bone targeting for the treatment of osteoporosis

Lühmann, Tessa; Germershaus, Oliver; Groll, Jürgen; Meinel, Lorenz

doi:10.1016/j.jconrel.2011.10.001

Cited by 82 publications

(62 citation statements)

References 182 publications

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“…21,22 As a bone-targeting drug agent, TC offers the advantages of being relatively nontoxic compared to bisphosphonates. 20,23,24 In addition, the biological activity of pharmaceutical TC is less susceptible to physicochemical factors and physiological environments compared with bone-targeting biological agents such as acidic oligopeptides and aptamers. 20, 25 Wang et al 26 reported the development of nanoparticles (NPs) that target bone tissue by poly(lactic-co-glycolic acid) copolymers and TC-based bonetargeting moieties and found that the NPs loaded with SV could improve the curative effects of SV on the recovery of bone mineral density in vivo.…”

Section: Introductionmentioning

confidence: 99%

Study of a new bone-targeting titanium implant–bone interface

Liu¹,

Zhang²,

Li³

et al. 2016

IJN

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Section: Introductionmentioning

confidence: 99%

Study of a new bone-targeting titanium implant–bone interface

Liu¹,

Zhang²,

Li³

et al. 2016

IJN

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“…BMD, frequently used as a proxy measure, accounts for approximately 70% of bone strength (a surrogate endpoint inmany clinical trials for osteoporosis), which is generally measuredby dual energy X-ray absorptiometry (DXA). It has been regarded as a good predictor for fracture risk [21], nevertheless, there are currently no accurate methods of measurement for overall bone strength. The World Health Organization (WHO) operationally defines osteoporosis as bone density 2.5 SDs below the mean for young white adult women.…”

Section: Diagnosismentioning

confidence: 99%

Mechanism of Treatment of Kidney Deficiency and Osteoporosis is Similar by Traditional Chinese Medicine

Wang¹,

Yue²,

Rahman³

et al. 2015

CPD

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Mechanism of Treatment of Kidney Deficiency and Osteoporosis is Similar by Traditional Chinese Medicinehttp://researchonline.ljmu.ac.uk/3126/ Article LJMU has developed LJMU Research Online for users to access the research output of the University more effectively. Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Users may download and/or print one copy of any article(s) in LJMU Research Online to facilitate their private study or for non-commercial research. You may not engage in further distribution of the material or use it for any profit-making activities or any commercial gain.The version presented here may differ from the published version or from the version of the record. Please see the repository URL above for details on accessing the published version and note that access may require a subscription. AbstractTraditional Chinese medicine (TCM) is a theoretical based system and is completely different from western medicine and states that numerous diseases, especially chronic diseases, are cured or relieved. "Zheng" (syndrome) is a summarization of the pathological changes which take place during the different stages of the development of a disease, including its location, cause and nature as well as the state of both Xie-qi (pathogenic factors) and Zheng-qi (healthy energy). Compared to a single symptom, syndrome can demonstrate the nature of a disease more extensively, completely and correctly. However, it is difficult to compare "Zheng" to the western medicine theory, which is based on scientific evidence for the diagnosis and treatment of a specific disease. Estrogen deficiency is a major pathogenetic factor in bone loss after menopause and oophorectomy with the subsequent risk of developing osteoporosis. According to TCM theory, the kidney stores essence and this can transform into bone marrow to nourish the bones, strenghthen the skeleton by promoting growth and repair. The kidney deficiency can decrease the estrogen level adjusted by the gonadal axis, causing osteoporosis. Traditional Chinese medicines tonifying the kidney can significantly enhance the level of estrogen to alleviate osteoporosis. In combination with other evidence, we further deduce that the syndrome as defined within TCM has a similar pathological mechanism to that defined by western medicine. If TCM theory is to be understood and accepted, and further fused with the western medicine theory, the micro pathological basis of TCM syndrome must be investigated extensively, which will lead to bridging the two theories together. The fusion of TCM with western medicine will pay more attention to analyzing the common nature and difference of disease and syndrome. This paper reviews the way forward for new translational advances.

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“…However, drug conjugates may suffer from instability of the active components during delivery to the site of action or at the site of action. 72 Therefore, a localized and controlled …”

Section: Nanoparticles For Localized Drug Delivery and Treatmentmentioning

confidence: 99%

“…Nanotechnology also provides new ways to enable or enhance local treatment of OVF, and a number of examples are listed in Table 4. [72][73][74][75][76][77] Specifically, a novel biodegradable thermosensitive drug carrier based on amphiphilic monomethoxypoly (ethylene glycol)-copoly(lactic-co-glycolic acid) (mPEG-PLGA) diblock copolymers has been developed for treating osteomyelitis. 76 The prepared mPEG-PLGA hydrogels were useful for formulation of injectable drug depots, and an in vivo study confirmed sustained release of teicoplanin from mPEG-PLGA hydrogel, which could efficiently treat osteomyelitis in rabbits and avoid the disadvantages of PMMA cement beads.…”

mentioning

confidence: 99%

Nanotechnology for treating osteoporotic vertebral fractures

Gao¹,

Wei²,

Yang³

et al. 2015

IJN

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Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided.

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Bone targeting for the treatment of osteoporosis

Cited by 82 publications

References 182 publications

Study of a new bone-targeting titanium implant–bone interface

Study of a new bone-targeting titanium implant–bone interface

Mechanism of Treatment of Kidney Deficiency and Osteoporosis is Similar by Traditional Chinese Medicine

Nanotechnology for treating osteoporotic vertebral fractures

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Bone targeting for the treatment of osteoporosis

Cited by 82 publications

References 182 publications

Study of a new bone-targeting titanium implant&ndash;bone interface

Study of a new bone-targeting titanium implant&ndash;bone interface

Mechanism of Treatment of Kidney Deficiency and Osteoporosis is Similar by Traditional Chinese Medicine

Nanotechnology for treating osteoporotic vertebral fractures

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Study of a new bone-targeting titanium implant–bone interface

Study of a new bone-targeting titanium implant–bone interface