Bone-targeting carbon dots: effect of nitrogen-doping on binding affinity

Lee, Kyung Kwan; Lee, Jae-Geun; Park, Chul Soon; Lee, Sun Hyeok; Raja, Naren; Yun, Hui-suk; Lee, Jeong-Soo; Lee, Chang‐Soo

doi:10.1039/c8ra09729a

Cited by 20 publications

(14 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spectrum was fitted with a spin-orbit doublet, where the P 2p 3/2 peak is centered at the BE of 133.2 eV, while the separation of the P 2p 1/2 component is shifted by only 0.9 eV. Results are consistent with already published data [33,35,63].…”

Section: The Chemical Characterization Of Implant Samplessupporting

confidence: 88%

“…The XPS spectra around N 1 s , C 1 s , P 2 p , and, O 1 s core-levels, measured on the alendronate-modified implant demonstrate the successful bonding of alendronate molecules to the implant surface. First of all, the best fit of the photoemission around C 1 s levels, shown in Figure 3 c, requires five fitting components, related to the characteristic bonds in the alendronate molecule, namely the aliphatic C–C, C–N, and P–C–O bonds at BEs of 285.0 eV, 286.0 eV, and 286.8 eV, respectively [ 63 , 64 ]. Additional C=O and O–C=O bonds can be assigned to surface contaminations.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A New Insight into Coating’s Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant

et al. 2020

View full text Add to dashboard Cite

Organophosphorus compounds, like bisphosphonates, drugs for treatment and prevention of bone diseases, have been successfully applied in recent years as bioactive and osseoinductive coatings on dental implants. An integrated experimental-theoretical approach was utilized in this study to clarify the mechanism of bisphosphonate-based coating formation on dental implant surfaces. Experimental validation of the alendronate coating formation on the titanium dental implant surface was carried out by X-ray photoelectron spectroscopy and contact angle measurements. Detailed theoretical simulations of all probable molecular implant surface/alendronate interactions were performed employing quantum chemical calculations at the density functional theory level. The calculated Gibbs free energies of (TiO2)10–alendronate interaction indicate a more spontaneous exergonic process when alendronate molecules interact directly with the titanium surface via two strong bonds, Ti–N and Ti–O, through simultaneous participation common to both phosphonate and amine branches. Additionally, the stability of the alendronate-modified implant during 7 day-immersion in a simulated saliva solution has been investigated by using electrochemical impedance spectroscopy. The alendronate coating was stable during immersion in the artificial saliva solution and acted as an additional barrier on the implant with overall resistivity, R ~ 5.9 MΩ cm2.

show abstract

Section: The Chemical Characterization Of Implant Samplessupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

A New Insight into Coating’s Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Alendronate‐based C‐dots have exhibited strong binding activity towards in vitro calcium‐deficient HA (the mineral component of bones), ex vivo rat femur and in vivo live zebrafish bone structures (Figure C1). The high affinity of C‐dots towards bone tissue was attributed to the residual bisphosphonate groups present on the C‐dots surface after carbonization; once the bisphosphonate functionality was blocked, the affinity towards bone was significantly decreased (Figure C2) …”

Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 89%

“…C) Schematic illustration of (C1) fluorescence imaging via the specific affinity of Alen‐C‐dots towards calcium‐deficient HA scaffolds (in vitro), rat femur (ex vivo), and live zebrafish (in vivo) and (C2) the preparation and bone affinity of Alen‐C‐dots and Alen‐EDA‐C‐dots. Reproduced with permission . Copyright 2019, The Royal Society of Chemistry.…”

Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

128

106

View full text Add to dashboard Cite

Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical‐sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon‐based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon‐based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon‐based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.

show abstract

“…Additionally, carbon dots (CDs) synthesized from alendronate have strong binding activity for calcium-deficient hydroxyapatite. 166 Alendronate-based CDs (Alen-CDs) showed enhanced bone targeting in the bone structures of zebrafish and rat femurs compared to nitrogen-doped CDs using ethylenediamine (Alen-EDA-CDs). These results were attributed to the bisphosphonate group on the surface of the CDs even after carbonization.…”

Section: A New Strategy For Tumor Therapy and Bone Regenerationmentioning

confidence: 99%

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

et al. 2021

View full text Add to dashboard Cite

Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard clinical treatment includes chemotherapy, surgical therapy, and radiation therapy. Unfortunately, surgical resection often fails to completely remove the tumor, which is the main cause of postoperative recurrence and metastasis, resulting in a high mortality rate. Moreover, bone tumors often invade large areas of bone, which cannot repair itself, and causes a serious effect on the quality of life of patients. Thus, bone tumor therapy and bone regeneration are challenging in the clinic. Herein, this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor therapy. The selected bifunctional materials include 3D-printed scaffolds, nano/microparticle-containing scaffolds, hydrogels, and bone-targeting nanomaterials. Numerous related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were reviewed. Finally, a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is discussed. This review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering.

show abstract

Bone-targeting carbon dots: effect of nitrogen-doping on binding affinity

Abstract: Fluorescent carbon dots selectively bind to skull tissues with high affinity, including a strong binding activity for calcium deficient hydroxyapatite, and rat femur, for bone targeted imaging.

Cited by 20 publications

References 63 publications

A New Insight into Coating’s Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant

A New Insight into Coating’s Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Contact Info

Product

Resources

About