Bone-targeted delivery of nanodiamond-based drug carriers conjugated with alendronate for potential osteoporosis treatment

Ryu, Taekyung; Kang, Rae Hyung; Jeong, Kyu Shik; Jun, Dae-Ryong; Koh, Jung‐Min; Kim, Doyun; Bae, Soo Kyung; Choi, Sung‐Wook

doi:10.1016/j.jconrel.2016.04.025

Cited by 74 publications

(51 citation statements)

References 41 publications

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“…34 Alendronate-conjugated nanoparticles exhibit rapid binding kinetics and strong binding affinity toward hydroxyapatite (HA). 35,36 In this study, we focused on the bisphosphonate group of alendronate due to its strong affinity toward calcium ions on apatite crystal surfaces; 37 these surfaces are exposed upon the collapse of the protein-mineral interface when a crack or inelastic deformation is generated. 38 In addition, bisphosphonates are oen used as ligands due to their therapeutic effects in various bone diseases (osteoporosis, Paget's disease, and metastatic bone cancer), as well as their high affinity toward bone tissue.…”

Section: Introductionmentioning

confidence: 99%

Bone-targeting carbon dots: effect of nitrogen-doping on binding affinity

Lee

Park

et al. 2019

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Bone-targeting carbon dots: effect of nitrogen-doping on binding affinity

Lee

Park

et al. 2019

RSC Adv.

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“…This observation was in agreement with the previous study conducted by T.-K. Ryu et al . where Alendronic acid conjugated nanodiamond showed extensive accumulation in osteoblastic cells (MC3T3-E1) but not non-targeted HepG2 and NIH3T3 cell types27. Specifically, protein tyrosine phosphatases were investigated as one of the possible bisphosphonate binding receptor presence on the surface of osteoblastic cells28.…”

Section: Resultsmentioning

confidence: 99%

Engineered Nanomedicine with Alendronic Acid Corona Improves Targeting to Osteosarcoma

Nguyen

Pitchaimani

Aryal

2016

Sci Rep

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We engineered nanomedicine with the stealth corona made up of densely packed bone seeking ligand, alendronic acid. In a typical nanoconstruct, alendronic acid is conjugated with hydrophilic head moiety of phospholipid that has an ability to self-assemble with hydrophobic polymeric core through its hydrophobic long carbon-chain. Proposed nanomedicine has three distinct compartments namely; poly(l-lactic-co-glycolic acid) polymeric core acting as a drug reservoir and skeleton of the nanoconstruct, phospholipid monolayer covers the core acting as a diffusion barrier, and a densely packed alendronic acid corona acting as a stabilizer and targeting moiety. Thus engineered nanomedicine attain spherical entity with ~90 ± 6 nm having negative zeta potential, −37.7 ± 2 mV, and has an ability to load 7 ± 0.3 wt% of doxorubicin. In-vitro bone targeting efficiency of nanomedicine was studied using hydroxyapatite crystals as a bone model, and found significant accumulation of nanoparticle in the crystals. Moreover, cellular internalization studies with mouse osteosarcoma confirm the selectivity of nanomedicine when compared to its internalization in non-targeted mouse melanoma. This nanomedicine shows prolong stability in serum and deliver the drug into the cell exhibiting an IC50 of 3.7 μM. Given the strong interacting property of alendronic acid with bone, the proposed nanomedicine hold promises in delivering drug to bone microenvironment.

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“…To leverage these results, Ryu et al . designed ND conjugated with Alen to deliver the drug to enhance bone cell activity and tissue repair [57]. To determine the applicability of NDs for bone drug delivery, they conducted affinity tests and determined that Alen-ND could bind favorably to the bone mineral HA, through interaction with HA and Alen.…”

Section: Types Of Nanomaterialsmentioning

confidence: 99%

“…Also, when Alen-NDs were injected intravenously into the rat tail vein, Alen-NDs deposited in bone tissue with high targeting efficiency. The authors hypothesized that the accumulation of NDs in bone to increase mechanical strength, and the delivery of Alen, could promote synergistic bone formation for future treatments of OP [57]. …”

Section: Types Of Nanomaterialsmentioning

confidence: 99%

Development of nanomaterials for bone-targeted drug delivery

Cheng

Chawla

Yang

et al. 2017

Drug Discovery Today

115

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Bone is one of the major organs of the human body; it supports and protects other organs, produces blood cells, stores minerals, and regulates hormones. Therefore, disorders in bone can cause serious morbidity, complications, or mortality of patients. However, despite the significant occurrence of bone diseases, such as osteoarthritis (OA), osteoporosis (OP), non-union bone defects, bone cancer, and myeloma-related bone disease, their effective treatments remain a challenge. In this review, we highlight recent progress in the development of nanotechnology-based drug delivery for bone treatment, based on its improved delivery efficiency and safety. We summarize the most commonly used nanomaterials for bone drug delivery. We then discuss the targeting strategies of these nanomaterials to the diseased sites of bone tissue. We also highlight nanotechnology-based drug delivery to bone cells and subcellular organelles. We envision that nanotechnology-based drug delivery will serve as a powerful tool for developing treatments for currently incurable bone diseases.

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Bone-targeted delivery of nanodiamond-based drug carriers conjugated with alendronate for potential osteoporosis treatment

Cited by 74 publications

References 41 publications

Bone-targeting carbon dots: effect of nitrogen-doping on binding affinity

Bone-targeting carbon dots: effect of nitrogen-doping on binding affinity

Engineered Nanomedicine with Alendronic Acid Corona Improves Targeting to Osteosarcoma

Development of nanomaterials for bone-targeted drug delivery

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