Bone structure: from cortical to calcium

Undifferentiated connective tissue dysplasia is one of the most common diseases of nowadays, which does not fit into the group of hereditary syndromes. This condition is diagnosed in 20–50% of the population at any age. The study aimed to correct the facial soft tissues of patients with undifferentiated connective tissue dysplasia through the cosmetic procedure of calcium hydroxylapatite injection. In 2018, a 36-year-old patient addressed the beauty salon with signs of undifferentiated connective tissue dysplasia, such as severe asymmetry of the face, infraorbital and nasolabial sulci, and thin and easily folding skin. Signs were observed from the age of 22, i.e., for 14 years. The therapy was performed using special features of the correction of facial soft tissue changes in patients with connective tissue dysplasia (CTD) using calcium hydroxylapatite-based products (Radiesse®, Merz North America, Inc., USA). Particular attention is given to the need for early correction to prevent premature skin aging related to this condition. After 14 days, a significant improvement of the patient’s skin condition was noted after the passing of two procedures. Her condition was estimated as consistent with T1-2P0G0A1Zh1 P1M1K1 and corresponded to grade I age-related changes in the superficial soft tissues. The performed treatment showed high efficacy in case of mild connective tissue dysplasia diagnosis. The results showed that when collecting information from anamnesis, the diagnostic criteria for dysplasia should be considered. If the criteria are met, the cosmetological correction with collagen stimulators becomes possible.

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“…e key signs of connective tissue dysplasia suggesting the presence of this pathology include the following [6]:…”

Section: Characteristic Features Of Connective Tissue Dysplasiamentioning

confidence: 99%

Cosmetic Syndrome Correction with Calcium Hydroxylapatite-Based Filler in Patients with Connective Tissue Dysplasia

Shirshakova¹,

Морозова

Sokolova³

et al. 2021

Dermatology Research and Practice

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“…A bone, an essential tissue in the human body, protects other tissues and organs in the body by structurally supporting it and provides the mechanical support that the body needs by storing hematopoiesis and minerals (Ca +2 and PO 4-) [72,73,74]. Bone tissue has a complex and compatible structure consisting of many organic and inorganic components in the macro and nanoscale range [75].…”

Section: Bone Structure and Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

“…In the skeletal system, there are more than 206 bones in the limbs (cylindrical shape and providing movement), short bones in the wrists (supporting), flat bones in the skull (flat and with a large surface area), and irregular bones in the pelvis and vertebrae. Bones are either in a compact or spongy form [72,80].…”

Section: Bone Structure and Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Mesoporous silica nanoparticles, methods of preparation and use of bone tissue engineering

Kütük

2021

International Journal of Life Sciences and Biotechnology

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Biomaterials are a large group of vitally important materials with many different inorganic and organic types. Biocomposites are produced by using materials such as polymer, metal, and ceramics. Bone tissue engineering deals with materials that can mimic the real bone structure found in the body. These materials used in the human body must be capable of many aspects such as their mechanical strength related to the area where they are used, as well as their properties such as biocompatible, biodegradable, and non-toxic. If the material is intended to treat the bone structure, it should be biodegradable, but it should be resistant to degradation if intended to be used for a long time. With the advance in technology, nanoparticles have become appealing in bone tissue engineering due to their many unique properties. In recent years, mesoporous silica nanoparticles (MSNs) have been prominent biomaterials in the medical field due to their properties such as alterable size structure, large pore volume, and surface area. This study aims to give information about the biomedical properties, synthesis methods, and importance of MSNs with unique properties in bone tissue engineering applications. This study is compiled by examining many studies in the literature.

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“…Since infancy, bone tissue always plays a significant role in human life. The unique composition and complex structure of bone determine its important functions in human [ 1 , 2 ], mainly including: protective, supporting, motor, storage and hematopoietic function [ [3] , [4] , [5] , [6] , [7] , [8] ]. In general, stiffness and toughness conflicts with each other, while bone tissue behaves these two mechanical properties and performs function at the same time.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired mineralized collagen scaffolds for bone tissue engineering

Ruan

et al. 2021

Bioactive Materials

186

112

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Successful regeneration of large segmental bone defects remains a major challenge in clinical orthopedics, thus it is of important significance to fabricate a suitable alternative material to stimulate bone regeneration. Due to their excellent biocompatibility, sufficient mechanical strength, and similar structure and composition of natural bone, the mineralized collagen scaffolds (MCSs) have been increasingly used as bone substitutes via tissue engineering approaches. Herein, we thoroughly summarize the state of the art of MCSs as tissue-engineered scaffolds for acceleration of bone repair, including their fabrication methods, critical factors for osteogenesis regulation, current opportunities and challenges in the future. First, the current fabrication methods for MCSs, mainly including direct mineral composite, in-situ mineralization and 3D printing techniques, have been proposed to improve their biomimetic physical structures in this review. Meanwhile, three aspects of physical (mechanics and morphology), biological (cells and growth factors) and chemical (composition and cross-linking) cues are described as the critical factors for regulating the osteogenic feature of MCSs. Finally, the opportunities and challenges associated with MCSs as bone tissue-engineered scaffolds are also discussed to point out the future directions for building the next generation of MCSs that should be endowed with satisfactorily mimetic structures and appropriately biological characters for bone regeneration.

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Bone structure: from cortical to calcium

Cited by 36 publications

References 13 publications

Cosmetic Syndrome Correction with Calcium Hydroxylapatite-Based Filler in Patients with Connective Tissue Dysplasia

Cosmetic Syndrome Correction with Calcium Hydroxylapatite-Based Filler in Patients with Connective Tissue Dysplasia

Mesoporous silica nanoparticles, methods of preparation and use of bone tissue engineering

Bioinspired mineralized collagen scaffolds for bone tissue engineering

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