Bone-specific alkaline phosphatase – a potential biomarker for skeletal growth assessment

Tripathi, Tulika; Gupta, Prahlad; Sharma, Jitender; Rai, Priyank; Gupta, Vinod Kumar; Singh, Navneet

doi:10.1080/14653125.2017.1416571

Cited by 24 publications

(37 citation statements)

References 34 publications

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“…In the present investigation, peak IGF-1 levels were seen in stage 4 CVMI at T1 and in stage 3 CVMI at T2 which was similar to previous studies 22,23,25–27,30,31 whereas Masoud et al . 21 reported peak IGF-1 levels at stage 5 CVMI.…”

Section: Discussionsupporting

confidence: 93%

“…In our earlier cross-sectional studies, we assessed the relationship of different biomarkers namely IGF-1, BALP and osteocalcin with skeletal growth estimated using CVMI. However, correlation was found to be significant for IGF-1 and BALP with skeletal maturity across CVMI stages 26,27 . Hence, we conducted a longitudinal study employing IGF-1 and BALP to determine their relationship with mandibular growth through different CVMI stages.…”

Section: Discussionmentioning

confidence: 79%

“…BALP followed a similar pattern at both T1 and T2 with peak levels in stage 3 which corresponded to the outcome of study by Tripathi et al . 27 . The results of our study also strengthened the results of previous studies where peak alkaline phosphatase levels were observed in pubertal phase of skeletal maturation in comparison to post pubertal phases 33–35 .…”

Section: Discussionmentioning

confidence: 99%

“…and exhibits increase in levels during adolescence 20 . Since promising results of BALP and IGF-1 in depicting skeletal growth has been observed in cross sectional studies in regard to concordance with CVMI 21–27 , we ventured into longitudinal assessment of the changes in serum IGF-1 and BALP during active growth period and further study the relationship between these biomarkers and mandibular length.…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal evaluation of the association between Insulin-like growth factor-1, Bone specific alkaline phosphatase and changes in mandibular length

Tripathi

Gupta

Rai

et al. 2019

Sci Rep

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The aim of the current longitudinal study was to assess the levels of serum Bone-specific alkaline phosphatase (BALP) and serum Insulin like growth factor-1 (IGF-1) in different cervical vertebral maturation index (CVMI) stages and observe their association with the mandibular growth. Blood samples and lateral cephalograms of 63 subjects (age group of 11–17 years) were obtained at two time points, 12 months apart. On the basis of CVMI, all subjects were divided into six groups based on whether the subjects remained in same CVMI stage or transitioned to the next CVMI stage. Annual mandibular length was related with serum BALP and serum IGF-1 levels estimated using ELISA. Serum IGF-1 and BALP attained highest levels at CVMI stage 3 with peak BALP levels observed earlier than IGF-1. Although a positive correlation was determined between IGF-1 and BALP but BALP followed skeletal growth pattern more precisely. Overall IGF-1 and BALP were negatively correlated with mandibular length with notable growth in CVMI groups 3–3 (P < 0.01), 3-4 (P < 0.01), 4-4 (P < 0.001) and 5-5 (P < 0.001). In conclusion, BALP is a potential biomarker for skeletal growth assessment. However, the mandibular growth pattern was independent of changes in IGF-1 and BALP.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Longitudinal evaluation of the association between Insulin-like growth factor-1, Bone specific alkaline phosphatase and changes in mandibular length

Tripathi

Gupta

Rai

et al. 2019

Sci Rep

Self Cite

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“…Jain és mtsai potenciális lehetőséget látnak ezen kötőfehérjék detektálásában, mivel mennyiségük szoros összefüggést mutatott a csigolyaérettségi stádiumokkal [44]. Tripathi és munkacsoportja osteocalcin [48] és csontspecifikus alkalikus foszfatáz [49] tekintetében talált ígéretes eredményeket, még mások a gingivalis sulcus váladék proteomikai elemzése kapcsán találtak a pubertás alatt szignifikánsan magasabb seroserotransferrin-és D-vitamin-kötő-fehérjeszinteket [50]. Mindezek alapján elmondhatjuk, hogy a szkeletális érettség meghatározása szempontjából a különböző szövetnedvekben jelen lévő biomarkerek még számos kiaknázatlan lehetőséget rejtenek, így nem meglepő, hogy egyre felkapottabb kutatási terültetnek is számítanak.…”

Section: Vérminta Vizelet éS Sulcusfolyadék Vizsgálataunclassified

Klasszikus és modern vizsgálómódszerek a csontérettségi kor és a pubertáskori növekedési csúcs meghatározására

et al. 2018

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The assessment of skeletal age is of utmost importance not only in the field of anthropology, forensic medicine, pediatrics, endocrinology but also in orthodontics and jaw orthopedics. Bone age refers to the individual’s biological development which can differ within a relatively wide range for the same chronological age. Therefore, accurate assessment of skeletal maturity and pubertal growth plays an important role in establishing a diagnosis for certain diseases. In addition, it is essential for proper timing and success of treatments in many cases. Currently, there are many methods available to determine skeletal age and pubertal growth spurt. During growth, bones undergo significant changes, the sequence of which is strongly determined. These changes can be measured by various methods including radiological examinations. More specifically, these classical methods are often based on the radiological evaluation of morphological changes in the hand bones and cervical vertebrae. Methods based on dental development also exist to assess the biologic maturity of an individual. However, thanks to three-dimensional imaging techniques and molecular diagnostic methods, even more accurate tests can be performed to determine biological maturity. These modern methods rely on the information obtained from the cone-beam computer tomograph records and on the measurements of biomarkers present in different circulatory or other body fluids. The purpose of this summary is to provide an overview of the various classical and modern methods for the assessment of skeletal age that could aid us in many fields of science. Orv Hetil. 2018; 159(35): 1423–1432.

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Association between blood markers and the progression of osseointegration in percutaneous prostheses patients—A pilot study

Miller,

Jeyapalina,

Agarwal

et al. 2024

J Biomed Mater Res

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Patients implanted with osseointegrated (OI) prosthetic systems have reported vastly improved upper and lower extremity prosthetic function compared with their previous experience with socket‐suspension systems. However, OI systems have been associated with superficial and deep‐bone infections and implant loosening due, in part, to a failure of the osseointegration process. Although monitoring the osseointegration using circulating biomarkers has clinical relevance for understanding the progression of osseointegration with these devices, it has yet to be established. Ten patients were enrolled in this study. Blood samples were collected at pre‐selected times, starting before implantation surgery, and continuing to 12 months after the second surgery. Bone formation markers, bone resorption markers, and circulating amino acids were measured from blood samples. A linear mixed model was generated for each marker, incorporating patient ID and age with the normalized marker value as the response variable. Post hoc comparisons were made between 1 week before Stage 1 Surgery and all subsequent time points for each marker, followed by multiple testing corrections. Serial radiographic imaging of the residual limb containing the implant was obtained during follow‐up, and the cortical index (CI) was calculated for the bone at the porous region of the device. Two markers of bone formation, specifically bone‐specific alkaline phosphatase (Bone‐ALP) and amino‐terminal propeptide of type I procollagen (PINP), exhibited significant increases when compared with the baseline levels of unloaded residual bone prior to the initial surgery, and they subsequently returned to their baseline levels by the 12‐month mark. Patients who experienced clinically robust osseointegration experienced increased cortical bone thickness at the porous coated region of the device. A medium correlation was observed between Bone‐ALP and the porous CI values up to PoS2‐M1 (p = .056), while no correlation was observed for PINP. An increase in bone formation markers and the lack of change observed in bone resorption markers likely reflect increased cortical bone formation induced by the end‐loading design of the Utah OI device used in this study. A more extensive study is required to validate the correlation observed between Bone‐ALP and porous CI values.

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Bone-specific alkaline phosphatase – a potential biomarker for skeletal growth assessment

Abstract: BALP showed promising results and can be employed as a potential biomarker for the estimation of growth status.

Cited by 24 publications

References 34 publications

Longitudinal evaluation of the association between Insulin-like growth factor-1, Bone specific alkaline phosphatase and changes in mandibular length

Longitudinal evaluation of the association between Insulin-like growth factor-1, Bone specific alkaline phosphatase and changes in mandibular length

Klasszikus és modern vizsgálómódszerek a csontérettségi kor és a pubertáskori növekedési csúcs meghatározására

Association between blood markers and the progression of osseointegration in percutaneous prostheses patients—A pilot study

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