Bone Resorption and Osteoporotic Fractures in Elderly Men: The Dubbo Osteoporosis Epidemiology Study

Meier, Christian; Nguyen, Tuan V.; Seibel, Markus J.; Eisman, John A.

doi:10.1359/jbmr.041207

Cited by 154 publications

(78 citation statements)

References 56 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Differences in the bone turnover markers (BTM) levels between men who did or did not have MetS were inconsistent. Since the association between BTM and fracture risk in men is doubtful, (50)(51)(52)(53) differences in bone turnover rate cannot explain lower fracture risk in men with MetS. History of fracture and of fall is associated with a higher risk of fracture.…”

Section: Discussionmentioning

confidence: 99%

Men with metabolic syndrome have lower bone mineral density but lower fracture risk—the MINOS study

Szulc

Varennes

Delmas

et al. 2010

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Data on the association of the metabolic syndrome (MetS) with bone mineral density (BMD) and fracture risk in men are inconsistent. We studied the association between MetS and bone status in 762 older men followed up for 10 years. After adjustment for age, body mass index, height, physical activity, smoking, alcohol intake, and serum 25-hydroxycholecalciferol D and 17b-estradiol levels, men with MetS had lower BMD at the hip, whole body, and distal forearm (2.2% to 3.2%, 0.24 to 0.27 SD, p < .05 to .005). This difference was related to abdominal obesity (assessed by waist circumference, waist-hip ratio, or central fat mass) but not other MetS components. Men with MetS had lower bone mineral content (3.1% to 4.5%, 0.22 to 0.29 SD, p < .05 to 0.001), whereas differences in bone size were milder. Men with MetS had a lower incidence of vertebral and peripheral fractures (6.7% versus 12.0%, p < .05). After adjustment for confounders, MetS was associated with a lower fracture incidence [odds ratio (OR) ¼ 0.33, 95% confidence interval (CI) 0.15-0.76, p < .01]. Among the MetS components, hypertriglyceridemia was most predictive of the lower fracture risk (OR ¼ 0.25, 95%CI 0.10-0.62, p < .005). Lower fracture risk in men with MetS cannot be explained by differences in bone size, rate of bone turnover rate and bone loss, or history of falls or fractures. Thus older men with MetS have a lower BMD related to the abdominal obesity and a lower risk of fracture related to hypertriglyceridemia. MetS probably is not a meaningful concept in the context of bone metabolism. Analysis of its association with bone-related variables may obscure the pathophysiologic links of its components with bone status. ß

show abstract

Section: Discussionmentioning

confidence: 99%

Men with metabolic syndrome have lower bone mineral density but lower fracture risk—the MINOS study

Szulc

Varennes

Delmas

et al. 2010

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

show abstract

“…(25) A recent report found that high bone resorption was associated with increased fracture risk in older men, independent of BMD. (28) The recent literature suggesting that ghrelin may play a role in short-term bone health is currently based on short-term animal studies only.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin and Bone: Is There an Association in Older Adults?: The Rancho Bernardo Study

Weiss

Langenberg

Barrett‐Connor

2006

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Laboratory studies suggest that ghrelin is involved in bone metabolism, but studies of ghrelin and bone in humans are limited. We studied sex-specific associations of ghrelin with BMD, NTX, and bone loss. Ghrelin was not associated with BMD or bone loss in either sex. There was a significant inverse association with NTX in men but not in women.Introduction: Ghrelin is a gastric hormone recently shown to be associated with bone metabolism in animal and in vitro studies. Studies in humans are limited. We investigated the association of ghrelin with BMD, the bone resorption marker N-telopeptide (NTX), and bone loss in older men and women. Materials and Methods: Participants were 977 community-dwelling men and non-estrogen-using postmenopausal women, 50-91 years of age. Plasma ghrelin was measured by radioimmunoassay from blood obtained between 1984 and 1987 . Between 1988 and 1991, BMD was measured at the midshaft radius by single photon absorptiometry and at the femoral neck, total hip, and lumbar spine by DXA. Axial BMD measurements were repeated an average of 4 years later in 544 participants. Bone turnover was assessed by NTX in urine obtained at the same time as the initial BMD. Multiple regression analyses were used to test sex-specific associations of ghrelin with BMD, NTX, and bone loss in both sexes. Results: No significant ghrelin-BMD or ghrelin-bone loss associations were observed in either sex, after adjusting for age and body mass index (BMI). Ghrelin was inversely associated with NTX in men and positively associated with NTX in women, independent of age. After adjusting for both age and BMI, this association reached statistical significance in men and was weakened in women. Conclusions: Ghrelin may be associated with bone turnover, but there is no evidence for an association with BMD or short-term change in BMD in older adults.

show abstract

“…We also showed that TRAP-5b was negatively correlated with Ca in women (β = −0.059, P = 0.039). Because it is well known that ALP is a classical marker for osteoid formation and calcification, and that Ca is important to maintain bone density and is lost with aging especially in women (Hannan et al 2000;Izumotani et al 2003;Meier et al 2005;Lanham-New 2008;Hien et al 2008), our present results suggest that TRAP-5b is a sensitive marker for screening for BMD in the general population of elderly individuals, especially women.…”

Section: Discussionmentioning

confidence: 60%

Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals

Irie

Hayashida

Shinkawa

et al. 2011

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4 ± 6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β = −0.005, p = 0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β = 0.001, p < 0.001), and triglyceride (β = −0.097, p = 0.016) in men, and with body mass index (β = −0.009, p = 0.025), alkaline phosphatase (β = 0.001, p < 0.001), calcium (β = −0.059, p = 0.039), and bone trabecular area ratio (β = −0.47, p = 0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women.

show abstract

Bone Resorption and Osteoporotic Fractures in Elderly Men: The Dubbo Osteoporosis Epidemiology Study

Cited by 154 publications

References 56 publications

Men with metabolic syndrome have lower bone mineral density but lower fracture risk—the MINOS study

Men with metabolic syndrome have lower bone mineral density but lower fracture risk—the MINOS study

Ghrelin and Bone: Is There an Association in Older Adults?: The Rancho Bernardo Study

Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals

Contact Info

Product

Resources

About