Bone repair in defects filled with AH Plus sealer and different concentrations of MTA: a study in rat tibiae

Abstract

Objectives This study aimed to evaluate the effects on bone repair of different concentrations of mineral trioxide aggregate (MTA) added to AH Plus. Materials and Methods Bone tissue reactions were evaluated in 30 rats ( Rattus norvegicus ) after 7 and 30 days. In the AH + MTA10, AH + MTA20, and AH + MTA30 groups, defects in the tibiae were filled with AH Plus with MTA in proportions of 10%, 20% and 30%, respectively; in the MTA-FILL group, MTA Fillapex was used; and in the control group, no sealer was used. The samples were histologically analyzed to assess bone union and maturation. The Kruskal-Wallis and Mann-Whitney tests were performed for multiple pairwise comparisons ( p ≤ 0.05). Results At the 7-day time point, AH + MTA10 was superior to MTA-FILL with respect to bone union, and AH + MTA20 was superior to MTA-FILL with respect to bone maturity ( p < 0.05). At the 30-day time point, both the AH + MTA10 and AH + MTA20 experimental sealers were superior not only to MTA-FILL, but also to AH + MTA30 with respect to both parameters ( p < 0.05). The results of the AH + MTA10 and AH + MTA20 groups were superior to those of the control group for both parameters and experimental time points ( p < 0.05). Conclusions The results suggest the potential benefit of using a combination of these materials in situations requiring bone repair.

Effect of Vitapex Combined with AH-Plus Paste on Inflammation in Middle-Aged and Elderly Patients with Periodontal-Endodontic Disease

“…The volume of the solidified paste is basically the same. There is no change in the above, the stability is good, and there is no large thermal expansion and contraction [18]. AH-Plus paste has good spatial stability and fluidity and can conform to the shape of the root canal after forming.…”

A Review of the research methods and progress of biocompatibility evaluation of root canal sealers

“…The tissue implantation experiments of sealers were divided into two types: soft tissue implantation [20,[49][50][51][52][53][54][55][56] and bone tissue implantation [49,57]. Soft tissue implantation was to embed the fresh and sterile sealer in the subcutaneous connective tissue of animals and usually selected the tissue of the animal's back.…”

Analysis of the cytotoxicity and bioactivity of CeraSeal, BioRoot™ and AH Plus® sealers in pre-osteoblast lineage cells

“…Non-surgical root canal treatment involves the removal of necrotic tissue, cleaning and decontaminating of the root canal and placement of a compatible material with human tissues that seals and promotes repair, which is usually the gutta percha cone with an endodontic filling sealer [ 6 , 7 ]. Endodontic sealers are materials that fill the space between the dentin walls and gutta-percha points along the entire root canal [ 8 ]. Their properties should include dimensional stability, biological sealing and biocompatibility with the adjacent tissues [ 9 ].…”

“…Their properties should include dimensional stability, biological sealing and biocompatibility with the adjacent tissues [ 9 ]. Sealers are classified according to their chemical constituents in zinc oxide and, eugenol, calcium hydroxide, glass ionomer, silicone, resin and bioceramic-based sealers [ 8 ].…”

“…With this issue in mind, bioceramic sealers were developed to improve the response of the apical and periapical tissue [ 18 ]. This compound may contain alumina, zirconia, bioactive glass, glass-ceramics, hydroxyapatite and calcium phosphates and are grouped in cements based on calcium silicate or calcium phosphate [ 8 ].…”