Bone remodelling at a glance

Crockett, Julie C.; Rogers, Michael J.; Coxon, Fraser P.; Hocking, Lynne J.; Helfrich, Miep

doi:10.1242/jcs.063032

Cited by 397 publications

(296 citation statements)

References 103 publications

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“…It is likely that, in addition to mineralization, osteoblasts under the tested conditions will secrete bone-related matrix proteins such as osteonectin and osteopontin. 23 Future studies will determine how protein expression is affected by these treatment conditions.…”

Section: Discussionmentioning

confidence: 99%

Peen treatment on a titanium implant: effect of roughness, osteoblast cell functions, and bonding with bone cement

Khandaker¹,

Riahinezhad²,

Sultana³

et al. 2016

IJN

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Implant failure due to poor integration of the implant with the surrounding biomaterial is a common problem in various orthopedic and orthodontic surgeries. Implant fixation mostly depends upon the implant surface topography. Micron to nanosize circular-shaped groove architecture with adequate surface roughness can enhance the mechanical interlock and osseointegration of an implant with the host tissue and solve its poor fixation problem. Such groove architecture can be created on a titanium (Ti) alloy implant by laser peening treatment. Laser peening produces deep, residual compressive stresses in the surfaces of metal parts, delivering increased fatigue life and damage tolerance. The scientific novelty of this study is the controlled deposition of circular-shaped rough spot groove using laser peening technique and understanding the effect of the treatment techniques for improving the implant surface properties. The hypothesis of this study was that implant surface grooves created by controlled laser peen treatment can improve the mechanical and biological responses of the implant with the adjoining biomaterial. The objective of this study was to measure how the controlled laser-peened groove architecture on Ti influences its osteoblast cell functions and bonding strength with bone cement. This study determined the surface roughness and morphology of the peen-treated Ti. In addition, this study compared the osteoblast cell functions (adhesion, proliferation, and differentiation) between control and peen-treated Ti samples. Finally, this study measured the fracture strength between each kind of Ti samples and bone cement under static loading. This study found that laser peen treatment on Ti significantly changed the surface architecture of the Ti, which led to enhanced osteoblast cell adhesion and differentiation on Ti implants and fracture strength of Ti–bone cement interfaces compared with values of untreated Ti samples. Therefore, the laser peen treatment method has the potential to improve the biomechanical functions of Ti implants.

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Section: Discussionmentioning

confidence: 99%

Peen treatment on a titanium implant: effect of roughness, osteoblast cell functions, and bonding with bone cement

Khandaker¹,

Riahinezhad²,

Sultana³

et al. 2016

IJN

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“…1,2 Osteoclasts and osteoblasts are respectively responsible for bone resorption and formation, while osteocytes are important in maintaining and controlling bone remodeling. [2][3][4][5] Bone remodeling is necessary for the repair of microfractures, as well as for skeletal adaptation to different mechanical stimuli and for calcium homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Osteoporosis and autophagy: What is the relationship?

Florencio‐Silva

Sasso

Simões

et al. 2017

Rev. Assoc. Med. Bras.

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Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits.

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“…Two BMPs, which are cytokines belonging to the TGF-β family, are FDA-approved for clinical use: BMP-2 (Infuse ® , MN, USA) [53] and BMP-7, which is coupled with bovine collagen type I as its carrier (OP-1 ® , Olympus, MA, USA) [54]. The clinical performance of each of these products has been comparable to autografts in certain BTE applications [55,56], and both products have received FDA approval for limited indications [55,57].…”

Section: Bmp-2mentioning

confidence: 99%

The Potential Impact of Bone Tissue Engineering in the Clinic

et al. 2016

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Bone tissue engineering (BTE) intends to restore structural support for movement and mineral homeostasis, and assist in hematopoiesis and the protective functions of bone in traumatic, degenerative, cancer, or congenital malformation. While much effort has been put into BTE, very little of this research has been translated to the clinic. In this review, we discuss current regenerative medicine and restorative strategies that utilize tissue engineering approaches to address bone defects within a clinical setting. These approaches involve the primary components of tissue engineering: cells, growth factors and biomaterials discussed briefly in light of their clinical relevance. This review also presents upcoming advanced approaches for BTE applications and suggests a probable workpath for translation from the laboratory to the clinic.

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Bone remodelling at a glance

Cited by 397 publications

References 103 publications

Peen treatment on a titanium implant: effect of roughness, osteoblast cell functions, and bonding with bone cement

Peen treatment on a titanium implant: effect of roughness, osteoblast cell functions, and bonding with bone cement

Osteoporosis and autophagy: What is the relationship?

The Potential Impact of Bone Tissue Engineering in the Clinic

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