Bone Regeneration and Periosteoplasty: A 250-Year-Long History

Lazzeri, Davide; Gatti, G; Romeo, Gianfranco; Balmelli, Bruno; Massei, A

doi:10.1597/08-085.1

Cited by 10 publications

(6 citation statements)

References 11 publications

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“…In 1779 Michele Troja observed the osteogenic capacity of the periosteum and Ollier (1867), confirmed that the inner layer of the isolated periosteum (cambium) can produce bone and is essential for transversal bone growth. Since these early discoveries, the presence of stem/progenitor cells in the periosteum has been confirmed and described in greater detail in numerous clinical observations (Lazzeri et al, 2009). Moreover, Caplan and colleagues (Nakahara et al, 1990a(Nakahara et al, ,b, 1991a have shown that cells in the periosteum possess chondro-and osteogenic capacity in vitro.…”

Section: The Periosteal Stem Cell Nichementioning

confidence: 91%

Niches for Skeletal Stem Cells of Mesenchymal Origin

Kurenkova

Medvedeva

Newton

et al. 2020

Front. Cell Dev. Biol.

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With very few exceptions, all adult tissues in mammals are maintained and can be renewed by stem cells that self-renew and generate the committed progeny required. These functions are regulated by a specific and in many ways unique microenvironment in stem cell niches. In most cases disruption of an adult stem cell niche leads to depletion of stem cells, followed by impairment of the ability of the tissue in question to maintain its functions. The presence of stem cells, often referred to as mesenchymal stem cells (MSCs) or multipotent bone marrow stromal cells (BMSCs), in the adult skeleton has long been realized. In recent years there has been exceptional progress in identifying and characterizing BMSCs in terms of their capacity to generate specific types of skeletal cells in vivo . Such BMSCs are often referred to as skeletal stem cells (SSCs) or skeletal stem and progenitor cells (SSPCs), with the latter term being used throughout this review. SSPCs have been detected in the bone marrow, periosteum, and growth plate and characterized in vivo on the basis of various genetic markers (i.e., Nestin, Leptin receptor, Gremlin1, Cathepsin-K, etc.). However, the niches in which these cells reside have received less attention. Here, we summarize the current scientific literature on stem cell niches for the SSPCs identified so far and discuss potential factors and environmental cues of importance in these niches in vivo . In this context we focus on (i) articular cartilage, (ii) growth plate cartilage, (iii) periosteum, (iv) the adult endosteal compartment, and (v) the developing endosteal compartment, in that order.

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Section: The Periosteal Stem Cell Nichementioning

confidence: 91%

Niches for Skeletal Stem Cells of Mesenchymal Origin

Kurenkova

Medvedeva

Newton

et al. 2020

Front. Cell Dev. Biol.

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“…Periosteum has since been determined to play a critical role in bone graft incorporation where its removal from autologous bone tissue transplants resulted in major decreases in bone healing and remodelling capacity. Removal of the cells from the bone marrow compartment of the graft had minimal effects indicating periosteum supplies the graft with crucial osteogenic and vascular components [171]. Indeed, vascularized periosteal bone grafts are routinely utilized in the treatment of atrophic nonunions and large segmental defects greater than 6 cm long [55], [172], [173].…”

Section: Periosteal Graftingmentioning

confidence: 99%

The in vitro production of endochondral bone from bovine periosteal explants

Collavino¹

2021

Preprint

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In the present study, periosteal tissue explants were explored as a substratum for the production of endochondral bone tissue in vitro. Endochondral bone is formed when mesenchymal stem cells (MSCs) proceed through the chondrogenic lineage to produce a transitory cartilage template which eventually is ossified. The periosteum is of interest as this tissue is found enveloping long bones and has been shown to contain a resident cellular population capable of generating endochondral bone. Endochondral ossification was induced in periosteal explants through the successive application of chondrogenic and hypertrophic/osteogenic media simulating the in vivo progression of the process. Different chondrogenic and osteogenic media types were utilized in order to assess the best method for producing osseous tissue. The results indicated that endochondral bone could be produced from periosteum tissue in vitro. It was determined that chondrogenic culture with transforming growth factor β1 (TGFβ1) led to the development of immature (resting or proliferative) cartilage tissue while chondrogenic culture with bone morphogenetic protein 2 (BMP2) produced mature (hypertrophic or calcified) cartilage and osseous tissue. Osteogenic media generally failed to improve ossification in cartilaginous explants but did affect their progression through the endochondral process. Cartilaginous periosteum explants responded differently to osteogenic media types based on the method of chondrogenic pre-induction. Immature cartilage formed under TGFβ1 induction underwent maturation in osteogenic media with triiodothyronine (T3). Mature cartilage formed under BMP2 continued to undergo maturation in the presence of osteogenic media with BMP2 or T3. Overall, these findings suggested that BMP2 is crucial in the development of endochondral bone from periosteal explants in vitro and that the osteogenic media is unnecessary in promoting this process.

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“…Multiple studies have been done on cleft lip and palate surgeries over the years. Since antiquity, many attempts have been carried out and various theories have been proposed to the process that leads to bone regeneration [2]. Three options currently exist to repair the cleft alveolus in patients with cleft lip and palate: primary bone grafting, secondary bone grafting and gingivoperiosteoplasty (GPP).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Bone Regeneration in Single Stage Closure of Cleft Alveolus with Gingivoperiosteoplasty

Kolari¹,

Sequiera²,

Hasoon³

et al. 2020

OJPed

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Background: Cleft alveolus closure is a challenge for cleft surgeon for many decades. Secondary alveolar bone grafting (SABG) is the preferred technique using autologous cancellous ileac crest bone as the donor graft. Many alternative methods were tried over the years with no any promising results. Gingivoperiosteoplasty (GPP) is a good alternative surgical technique for bone regeneration in cleft alveolus with proper case selection criteria. Aim: Aim of the study was to evaluate the bone regeneration following closure of cleft alveolus with gingivoperiosteoplasty. Method: This study was carried out in the

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Bone Regeneration and Periosteoplasty: A 250-Year-Long History

Cited by 10 publications

References 11 publications

Niches for Skeletal Stem Cells of Mesenchymal Origin

Niches for Skeletal Stem Cells of Mesenchymal Origin

The in vitro production of endochondral bone from bovine periosteal explants

Evaluation of Bone Regeneration in Single Stage Closure of Cleft Alveolus with Gingivoperiosteoplasty

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