Abstract:In the present study, periosteal tissue explants were explored as a substratum for the production of endochondral bone tissue in vitro. Endochondral bone is formed when mesenchymal stem cells (MSCs) proceed through the chondrogenic lineage to produce a transitory cartilage template which eventually is ossified. The periosteum is of interest as this tissue is found enveloping long bones and has been shown to contain a resident cellular population capable of generating endochondral bone. Endochondral ossificatio… Show more
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