Bone Quality Assessment by Quantitative Ultrasound of Proximal Phalanxes of the Hand in Healthy Subjects Aged 3–21 Years

Baroncelli, Gi; Federico, Giovanni; Bertelloni, Silvano; F, de Terlizzi; Cadossi, Ruggero; Saggese, Giuseppe

doi:10.1203/00006450-200105000-00017

Cited by 104 publications

(77 citation statements)

References 39 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data confirm the previous observations made by Ritschl et al (2005), who speculated that it could be a link between the progressive reduction of mcSoS and the increase of BMI in the first months. In our study, mcSoS appeared to inversely correlate with weight and BMI at enrollment, confirming the results of other studies performed both in adults and in children (Baroncelli et al, 2001;Vignolo et al, 2003). As suggested by Ritschl et al, mcBTT is constant but non-significantly decreasing until 12 months of life.…”

Section: Discussionsupporting

confidence: 92%

Bone mineral status in breast-fed infants: influence of vitamin D supplementation

et al. 2011

View full text Add to dashboard Cite

Background/Objectives: To assess bone status using quantitative ultrasound (QUS) applied to the second metacarpus and to evaluate the influence of vitamin D supplementation on bone mineralization in exclusively breast-fed infants. Subjects/Methods: Seventy seven healthy exclusively breast-fed infants aged o12 months underwent QUS evaluation with QUS DBM Sonic Aurora IGEA (MO, Italy), which measures speed of sound (mcSoS) and bone transmission time (mcBTT). Z-scores for age and length were also considered. Infants were divided into two groups, considering vitamin D supplementation. Results: mcSoS and mcBTT were significantly lower in the group of breast-fed infants without vitamin D supplementation (respectively, P ¼ 0.001 and P ¼ 0.015). A statistically significant difference was also observed between the two groups for Z-scores of QUS parameters for age and length, with lower levels in infants not supplemented with vitamin D. Both mcSoS and mcBTT decline during the first year of life. mcSoS inversely correlated with weight at enrollment and BMI at enrollment. Conclusions: Our data support the importance of vitamin D supplementation in exclusively breast-fed infants in the first period of life to provide an adequate bone development.

show abstract

Section: Discussionsupporting

confidence: 92%

Bone mineral status in breast-fed infants: influence of vitamin D supplementation

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The positive correlation between bone size and ultrasound variables exists because body height influences the mechanical forces applied to the skeleton and subsequently bone strength. It seems, however, that QUS techniques-especially Ad-SoS-may be less affected by bone size than DXA measurements [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…It was calculated by means of a standard Z-score transformation using mean value and standard deviation appropriate for age and sex groups. Normative data for phalangeal quantitative ultrasound variables were published [12,16,18,19]. The coefficient of variation (CV%) for QUS measurements was 0.64%.…”

Section: Laboratory Investigationsmentioning

confidence: 99%

“…However, it may not be appropriate for assessing a maturing skeleton, as it allows only two-dimensional measurements and depends on bone size, therefore making the results potentially inaccurate [10]. Measurements made by quantitative ultrasound (QUS) are less influenced by bone size [11][12][13]. Importantly, when considering the paediatric population, no radiation is used and costs are relatively low.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bone status in adolescents with type 1 diabetes

Chobot¹,

Haffke

Polańska

et al. 2010

Diabetologia

View full text Add to dashboard Cite

Aims The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other diseaserelated and growth variables was analysed. Methods Group I consisted of 99 pubertal (Tanner ≥2) adolescents (49 female No correlation between Ad-SoS SDS and sex, DIR or diabetes duration was observed. The lower Ad-SoS SDS reflects reduced bone status, and the reduction was significantly more marked in those patients whose HbA 1c T was higher than 7.0% when compared with those whose HbA 1c T was lower. Conclusions Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent on long-term metabolic control.

show abstract

“…20,[48][49][50][51][52][53][54] The few studies that assessed calcaneal QUS in prepubertal children aged 6-10 years showed a progressive increase of broadband ultrasound attenuation and a small or no increase of speed of sound with age. 48,[50][51][52] Only two studies established SI reference or normative data in children, adolescents and young adults in the age range from 6 to 21 years.…”

Section: S79mentioning

confidence: 99%

Reference values of bone stiffness index and C-terminal telopeptide in healthy European children

et al. 2014

View full text Add to dashboard Cite

,9 on behalf of the IDEFICS consortium BACKGROUND/OBJECTIVE: Quantitative ultrasound measurements and bone metabolic markers can help to monitor bone health and to detect impaired skeletal development. Population-based reference values for children may serve as a basis for preventive measures to reduce the risk of osteoporosis and osteoporotic fractures in later life. This is the first paper providing age-, sex-and height-specific reference values for bone stiffness index (SI) and serum carboxy-terminal cross-linking telopeptide of type I collagen (CTX) in healthy, apparently prepubertal children. SUBJECTS/METHODS: In the population-based IDEFICS baseline survey (2007)(2008) and follow-up (2009-2010), 18 745 children from eight European countries were newly recruited. A total of 10 791 2-10.9-year-old and 1646 3-8.9-year-old healthy children provided data on SI of the right and left calcaneus and serum CTX, respectively. Furthermore, height and weight were measured. Percentile curves were calculated using the General Additive Model for Location Scale and Shape (GAMLSS) to model the distribution of SI and CTX depending on multiple covariates while accounting for dispersion, skewness, and the kurtosis of this distribution. RESULTS: SI was negatively associated with age and height in children aged 2-5 years, whereas a positive association was observed in children aged 6-10 years. The dip in SI occurred at older age for higher SI percentiles and was observed earlier in taller children than in smaller children. The CTX reference curves showed a linear-positive association with age and height. No major sex differences were observed for the SI and CTX reference values. CONCLUSION: These reference data lay the ground to evaluate bone growth and metabolism in prepubertal children in epidemiological and clinical settings. They may also inform clinical practice to monitor skeletal development and to assess adverse drug reactions during medical treatments.

show abstract

Bone Quality Assessment by Quantitative Ultrasound of Proximal Phalanxes of the Hand in Healthy Subjects Aged 3–21 Years

Cited by 104 publications

References 39 publications

Bone mineral status in breast-fed infants: influence of vitamin D supplementation

Bone mineral status in breast-fed infants: influence of vitamin D supplementation

Bone status in adolescents with type 1 diabetes

Reference values of bone stiffness index and C-terminal telopeptide in healthy European children

Contact Info

Product

Resources

About