Bone Oxidative Changes during Early Fracture Healing of Postmenopausal Osteoporosis Rat Model

Shuid, Ahmad Nazrun; Mohamad, Suharni; Mohamed, Norazlina; Mokhtar, Sabarul Afian; Muhammad, Norliza; Soelaiman, Ima Nirwana

doi:10.3923/ajava.2011.1193.1203

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…42,43 Another study using the same animal model demonstrated that TRF supplementation (60 mg/kg) reduced lipid peroxidation during early fracture healing through a reduction in the levels of free radicals responsible for the delayed healing process. 44 Tocotrienols also greatly benefit inflammationmediated bone loss, such as rheumatoid arthritis (RA) and osteoarthritis (OA). A recent study by Zainal et al using an animal model of RA reported that oral TRF supplementation (30 mg/kg) was able to reduce the joint inflammation seen at the paws and reduced the plasma levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and CRP in the treated rats compared to the untreated controls.…”

mentioning

confidence: 99%

<p>Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability</p>

Zaffarin¹,

Ng²,

Ng³

et al. 2020

IJN

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mentioning

confidence: 99%

<p>Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability</p>

Zaffarin¹,

Ng²,

Ng³

et al. 2020

IJN

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“…The third and fourth groups were ovariectomized and treated with calcium 1% (Ca) ad libitum and force-fed with 500 mg/kg C. caudatus extract (CC) respectively. The ovariectomy and sham operation protocol was carried out as previously described [18]. Rats were left recuperating for 1 week before commencing the treatment.…”

Section: Methodsmentioning

confidence: 99%

The effects of Cosmos caudatus (ulam raja) on dynamic and cellular bone histomorphometry in ovariectomized rats

Mohamed

Sahhugi²,

Ramli

et al. 2013

BMC Res Notes

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BackgroundCosmos caudatus is a local plant which has antioxidant properties and contains high calcium. It is also reported to be able to strengthen the bone. This report is an extension to previously published article in Evidence Based Complementary and Alternative Medicine (doi:10.1155/2012/817814). In this study, we determined the effectiveness of C. caudatus as an alternative treatment for osteoporosis due to post-menopause by looking at the dynamic and cellular paramaters of bone histomorphometry.MethodsForty female Wistar rats were divided into four groups i.e. sham operated, ovariectomized, ovariectomized treated with calcium 1% ad libitum and ovariectomized force-fed with 500 mg/kg C. caudatus extract. Treatment was given six days a week for eight weeks.ResultsDynamic and cellular histomorphometry parameters were measured. C. caudatus increased double-labeled surface (dLS/BS), mineral appositional rate (MAR), osteoid volume (OV/BV) and osteoblast surface (Ob.S/BS). C. caudatus also gave better results compared to calcium 1% in the osteoid volume (OV/BV) parameter.ConclusionsC. caudatus at the 500 mg/kg dose may be an alternative treatment in restoring bone damage that may occur in post-menopausal women.

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Effects of Vitamin E on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats

Feresin

Johnson

Elam

et al. 2013

Journal of Osteoporosis

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The present study examined the dose-dependent effect of vitamin E in reversing bone loss in ovariectomized (Ovx) rats. Sprague-Dawley rats were either Sham-operated (Sham) or Ovx and fed control diet for 120 days to lose bone. Subsequently, rats were divided into 5 groups (n = 12/group): Sham, Ovx-control, low dose (Ovx + 300 mg/kg diet; LD), medium dose (Ovx + 525 mg/kg diet; MD), and high dose (Ovx + 750 mg/kg diet; HD) of vitamin E and sacrificed after 100 days. Animals receiving MD and HD of vitamin E had increased serum alkaline phosphatase compared to the Ovx-control group. Bone histomorphometry analysis indicated a decrease in bone resorption as well as increased bone formation and mineralization in the Ovx groups supplemented with MD and HD of vitamin E. Microcomputed tomography findings indicated no effects of vitamin E on trabecular bone of fifth lumbar vertebrae. Animals receiving HD of vitamin E had enhanced fourth lumbar vertebra quality as evidenced by improved ultimate and yield load and stress when compared to Ovx-control group. These findings demonstrate that vitamin E improves bone quality, attenuates bone resorption, and enhances the rate of bone formation while being unable to restore bone density and trabecular bone structure.

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Bone Oxidative Changes during Early Fracture Healing of Postmenopausal Osteoporosis Rat Model

Cited by 5 publications

References 24 publications

<p>Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability</p>

<p>Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability</p>

The effects of Cosmos caudatus (ulam raja) on dynamic and cellular bone histomorphometry in ovariectomized rats

Effects of Vitamin E on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats

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