Bone Mineral Status in Hypopituitarism

Arisaka, Osamu; Arisaka, Madoka; Hosaka, Atsuto; Yabuta, Keijiro

doi:10.1001/archpedi.1989.02150150022007

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Sir: Pneumocystis carinii pneumonia (PCP) is the most common serious infection in patients with acquired immunodeficiency syndrome (AIDS) and shows a high mortality rate [1][2][3].…”

Section: Steroids In Pneumocystis Carinii Pneumonia In Hiv Seropositimentioning

confidence: 99%

“…Osteopenia in male hypogonadism, especially in adolescent boys, and concomitant androgen therapy has been only rarely reported [3,5]. Testosterone enanthate 125 mg every 3 weeks (total four times) led to a significant increase in bone density to 0.57 g/cm 2.During puberty, a marked increase in bone density occurs and this is thought to be due to increased sex steroid secretion [1,2,4,6]. There was no anosmia.…”

mentioning

confidence: 99%

“…During puberty, a marked increase in bone density occurs and this is thought to be due to increased sex steroid secretion [1,2,4,6]. Androgen deficiency during puberty seems to be a risk factor for osteopenia in adolescent boys and young male adults [1,4,5].…”

mentioning

confidence: 99%

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Increase in bone density during testosterone therapy in adolescent hypogonadism

Arisaka

Hosaka

et al. 1989

Eur J Pediatr

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Sir: Abundant evidence links decreased bone density with oestrogen-deficient status in women, and increases in bone density have been noted after oestrogen therapy [7]. Osteopenia in male hypogonadism, especially in adolescent boys, and concomitant androgen therapy has been only rarely reported [3,5]. Recently, we investigated the effect of testosterone therapy on bone density in a boy with hypogonadotropic hypogonadism.A 17-year-old boy with Tanner stage I external genitalia was diagnosed as having an idiopathic isolated gonadotropin deficiency based upon the results of both a luteinizing hormone-releasing hormone test and a human chorionic gonadotropin (HCG) loading test. There was no anosmia. Plasma testosterone response to HCG stimulation (HCG 3000 units/m 2 for 3 days) rose from 10 ng/dl (basal level) to 90 ng/dl (peak level). Plasma somatomedin C concentration was 1.5U/ml (normal = 1.35-3.0). The patient's skeletal age was 13 years. Serum calcium, phosphorus, carboxyterminal parathyroid hormone, calcitonin, and vitamin D metabolites (25-hydroxy vitamin D and 1,25-dihydroxy vitamin D) were all within normal limits.Bone mineral density evaluated by single-photon absorptiometry at the non-dominant distal radius was decreased: 0.50g/cm 2 (normal 0.59 +_ 0.05). Testosterone enanthate 125 mg every 3 weeks (total four times) led to a significant increase in bone density to 0.57 g/cm 2.During puberty, a marked increase in bone density occurs and this is thought to be due to increased sex steroid secretion [1,2,4,6]. Androgen deficiency during puberty seems to be a risk factor for osteopenia in adolescent boys and young male adults [1,4,5]. As shown by our patient, testosterone replacement at the appropriate age stimulates the pubertal increase in bone density and increases the skeletal resistance to mechanical forces.

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“…Sir: Pneumocystis carinii pneumonia (PCP) is the most common serious infection in patients with acquired immunodeficiency syndrome (AIDS) and shows a high mortality rate [1][2][3].…”

Section: Steroids In Pneumocystis Carinii Pneumonia In Hiv Seropositimentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Increase in bone density during testosterone therapy in adolescent hypogonadism

Arisaka

Hosaka

et al. 1989

Eur J Pediatr

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Assessment of Depression in Medically Ill Children Presenting to Pediatric Specialty Clinics

Shemesh¹,

Yehuda²,

Rockmore³

et al. 2005

Journal of the American Academy of Child & Adolescent Psych

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Growth hormone deficiency during puberty reduces adult bone mineral density.

Hyer

Rodin

Tobias

et al. 1992

Archives of Disease in Childhood

120

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Bone mineral density (BMD) was evaluated by dual energy x ray absorptiometry in 60 adults (33 males, 27 females; aged 50, range 23-76 years) who were growth hormone deficient from various causes for 10-4 (1-31) years. Adult patients who had acquired growth hormone deficiency before completion of puberty had significantly reduced mean (SEM) BMD compared with age matched healthy controls at the lumbar spine: 0-87 (0.09) v 1-20 (0.03) g/cm2, femoral neck: 0-81 (0-06) v 1-08 (0.04) g/cm2, and Ward's triangle: 0-68 (0.07) v 1-04 (0.05) g/cm2. These values were also reduced compared with those of patients who had received human growth hormone during puberty. Untreated growth hormone deficiency when present during puberty results in reduced adult bone density.

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Bone Mineral Status in Hypopituitarism

Cited by 4 publications

References 9 publications

Increase in bone density during testosterone therapy in adolescent hypogonadism

Increase in bone density during testosterone therapy in adolescent hypogonadism

Assessment of Depression in Medically Ill Children Presenting to Pediatric Specialty Clinics

Growth hormone deficiency during puberty reduces adult bone mineral density.

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