Bone mineral density, osteopenia and osteoporosis among US adults with cancer

Abstract

Background Bone mineral deficits are one of the most common complications in cancer survivors. However, there are no studies evaluating bone mineral density (BMD) and the prevalence of osteopenia and osteoporosis among patients with different types of cancers. Aim The objective was to assess BMD and evaluate the prevalence of osteopenia and osteoporosis among US adults with cancer. Design A cross-section propensity score matching study. Methods We extracted data from National Health and Nutrition Examination Survey database from 2005 to 2018. We compared BMD in participants with and without cancer which was further analyzed according to cancer type. We conducted logistic regression to evaluate adjusted odds ratios of osteopenia and osteoporosis and determine risk factors for their development. Results We found that BMD was significantly higher in participants without cancer than cancer patients. Furthermore, the median BMD of patients with breast cancer or skin cancer (including melanoma) was significantly lower than participants without cancer. People with breast, lung, genitourinary and skin cancers were more likely to incur osteopenia/osteoporosis than those without cancer. Conclusions BMD differs depending upon type in survivors. Individuals with a history of cancer have a poor understanding of osteoporosis and its risk factors. Understanding risk factors in patients with cancers identified in our study may be helpful for preventing osteoporosis and fractures and the development of screening guidelines.

Exploring quality evaluation markers of Fructus Psoraleae based on chemometric analysis integrated with network pharmacology

“…It is evidenced that glycolysis is the primary metabolic pathway to meet ATP requirements during osteoblast differentiation, with Wnt signalling inducing osteoblast differentiation and activating glycolysis via mammalian rapamycin targets 48 . Besides, it has been reported that patients with cancer suffer from significantly lower bone mineral density than healthy people due to various reasons, such as bone metastases, making them susceptible to osteopenia or osteoporosis 49 . This is particularly true for patients with prostate cancer and breast cancer who need chemotherapy and endocrine therapy which can induce hypogonadism, thus leading to an increased rate of bone loss 50 .…”

“…48 Besides, it has been reported that patients with cancer suffer from significantly lower bone mineral density than healthy people due to various reasons, such as bone metastases, making them susceptible to osteopenia or osteoporosis. 49 This is particularly true for patients with prostate cancer and breast cancer who need chemotherapy and endocrine therapy which can induce hypogonadism, thus leading to an increased rate of bone loss. 50 So, we assumed that chemometric markers can alleviate the symptoms of osteoporosis from its aetiology by inhibiting multiple cancer signalling pathways, such as Wnt/β-catenin signalling, calcium signalling, ERK signalling, and so on.…”

Association Between Coronary Artery Calcium Score and Bone Mineral Density in Type 2 Diabetes Mellitus with Different Visceral Fat Area

“…The subjects who met the following criteria were excluded: (1) patients with acute complications of diabetes, acute coronary syndrome and other high-risk characteristics; (2) patients with myocardial infarction, angina pectoris, valvular heart disease, cardiomyopathy; 16 (3) those who had previously undergone coronary artery bypass grafting or percutaneous coronary stenting; 17 (4) those who took lipid-lowering drugs such as atorvastatin or rosuvastatin in half year; 18 (5) Those with severe liver and kidney dysfunction; (6) those with diseases that significantly affected bone metabolism, such as hyperthyroidism and hypoparathyroidism; 19,20 (7) those who took calcium, vitamin D, antiepileptic drugs, hormones and other drugs that significantly affected bone metabolism within 1 year; 21 (8) those with malignant tumors and autoimmune diseases; 22,23 (9) relevant information was incomplete.…”

Osteoporosis in Patients With Respiratory Diseases

“…Lung cancer was the most dangerous factor of bone mineral density changes in respiratory diseases ( Savula et al, 2004 ). Osteopenia and osteoporosis were more likely to occur in people with lung cancer ( Huang et al, 2022 ). Among different types of lung cancer, non-small cell lung cancer was most associated with osteoporosis, and bone metastasis was also the risk factor for its negative prognosis ( Rinaldi et al, 2019 ).…”