Bone mineral density of patients with chronic plaque psoriasis

Millard, T. P.; Antoniades, L; Evans, A. Mark; Smith, H. R.; Spector, Tim D.; Barker, Jonathan

doi:10.1046/j.1365-2230.2001.00855.x

Cited by 49 publications

(53 citation statements)

References 13 publications

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“…In a small study of patients with plaque psoriasis those with associated psoriatic arthropathy had a significantly lower mean lumbar spine Z-score (-1.16) than those without arthropathy (+1.38, P =0.015), while neither previous nor current treatment with systemic steroids, retinoids or methotrexate significantly affected BMD [28]. However, several other studies have determined normal total, peripherial or periarticular bone mass in patients with PsA, i.e it was not different from the control group [11][12][13].…”

Section: Discussionmentioning

confidence: 91%

Osteoporosis in psoriatic arthritis: Is there any?

Grazio

Cvijetić

Vlak

et al. 2011

Wien Klin Wochenschr

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Aims: Although considered as a feature of inflammatory rheumatic diseases, there is a lot of controversy around low bone mass in patients with psoriatic arthritis. The aim of this cross-sectional study was to analyze bone mineral density in patients with psoriatic arthritis, as well as to investigate its possible association with some measures of disease activity and functional capacity. Subjects and Methods:Sixty-nine patients with established psoriatic arthritis (mean age 56.20±12.23 years) and who has not been treated with specific antiosteoporotic drugs were recruited from the outpatient clinic database. Bone mineral density was measured by dual-energy X-ray absorptiometry at the lumbar spine and at the left hip. Disease activity measures included: duration of morning stiffness, tender and swollen joint count, patient's and physician's global assessment, presence of dactylitis and enthesitis, ESR, CRP and Disease Activity Score 28. Health Assessment Questionnaire was used to assess functional status.Results: According to WHO definition, spinal osteoporosis was found in 7.2% of patients, total hip osteoporosis in 1.4% of patients and femoral neck osteoporosis in 2.9% of patients. There was no significant association of any of the measures of disease activity with BMD at any site. Higher HAQ scores were associated with lower total hip BMD.Conclusions: In our sample of patients with psoriatic arthritis we did not find increased prevalence of osteoporosis. There was no association of BMD with indices of disease activity, while negative correlation was found between HAQ and total hip BMD.

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Section: Discussionmentioning

confidence: 91%

Osteoporosis in psoriatic arthritis: Is there any?

Grazio

Cvijetić

Vlak

et al. 2011

Wien Klin Wochenschr

View full text Add to dashboard Cite

show abstract

“…Psoriasis patients with or without arthritis may suffer from osteoporosis (102). However, a previous study showed that patients with chronic plaque psoriasis had a low BMD despite risk factors, although the subgroup with joint involvement appeared to be at a higher risk of developing osteoporosis and therefore required prevention therapy (103). Reduced BMD has been linked to palmoplantar pustular psoriasis (104).…”

Section: Bone Status In Patients With Psoriasis Treated With Uvb Photmentioning

confidence: 99%

UVB and Vitamin D in Psoriasis

Osmancevic¹

2012

Psoriasis

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“…The effect of GC on bone mass of SpA patients is not sufficiently investigated. Some authors are of the opinion that GC cumulative doses is not a factor in the successful prognosis of BMD decrease [Bjarnason, 1997;Habtezion, 2002;Millard, 2001). Several clinical studies have shown that GC in doses of less than 7,5 mg/d does not incite more pronounced bone resorbtion (Bijlsma, 2000;Nishimura, 2000).…”

Section: Discussionmentioning

confidence: 99%