Bone mineral density of both genders in Type 1 diabetes according to bone composition

Hadjidakis, D.; Raptis, Athanasios; Sfakianakis, Michael; Mylonakis, A.; Raptis, Sotirios A.

doi:10.1016/j.jdiacomp.2005.07.006

Cited by 70 publications

(50 citation statements)

References 22 publications

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“…In the present study, our results showed a significant decrease in femoral diabetic BMD values, measured by DXA, confirming that the evolution time of diabetes has a deleterious effect on the metabolically active trabecular bone of premenopausal rats. Recently, several clinical investigations also demonstrated that premenopausal women with type 1 diabetes mellitus show significantly lower femoral neck BMD than that of healthy individuals (Hadjidakis et al, 2006). Whereas the objective of this study was to evaluate the relationship between lipid peroxidation index, antioxidant defense and bone metabolism, with emphasis on histomorphometric analysis, biomechanical testing and BMD, there is no serum biochemical analysis associated to bone and mineral metabolism.…”

Section: Discussionmentioning

confidence: 98%

Relationship between oxidative stress and diabetic osteopenia in premenopausal rats

Duarte

Rodrigues

Rezende

et al. 2010

Braz. J. Pharm. Sci.

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The relationship between lipid peroxidation, antioxidant defense and diabetic osteopenia remains unclear. This study evaluated the relationship among lipid peroxidation index, antioxidant defense parameters and bone metabolism in a premenopausal diabetic model using measures including thiobarbituric acidreactive substances concentration (TBARS) and reduced glutathione (GSH) content in brain homogenates, histomorphometric analysis, biomechanical testing and bone mineral density (BMD). Female Wistar rats with regular estrous cycle were divided into two groups: Group 1: control rats (n = 15) and Group 2: diabetic rats (n = 15). Diabetes was induced by alloxan and confirmed by glycemia ≥250 mg/dL. The lipid peroxidation index, measured by TBARS concentration, showed a significant increase (p<0.05) in diabetic animals in comparison to control animals. However, the antioxidant parameter measured by GSH content, was significantly lower (p<0.05) in diabetic animals. Histomorphometric analysis showed a significant increase (p<0.05) in femoral trabecular separation together with a significant decrease (p<0.05) in trabecular thickness, and reduced trabecular bone volume in diabetic rats. Moreover, biomechanical testing and BMD values were significantly lower (p<0.05) in the diabetic group. Thus, our results demonstrated that increased lipid peroxidation and altered antioxidant defense could be related to the development of oxidative stress and diabetic osteopenia in premenopausal rats.Uniterms: Oxidative stress. Lipid peroxidation. Diabetes mellitus. Diabetic osteopenia/experimental study.A relação entre peroxidação lipídica, defesa antioxidante e osteopenia diabética permanece obscura. Este estudo avaliou a associação entre índice de peroxidação lipídica, parâmetro de defesa antioxidante e metabolismo ósseo em um modelo diabético pré-menopausa através de medidas como a concentração de substâncias reativas ao ácido tiobarbitúrico (SRAT) e conteúdo de glutationa reduzida (GSH) no homogenato cerebral, análises histomorfométricas, teste biomecânico e densidade mineral óssea (DMO). Ratos Wistar fêmeas com ciclo estral regular foram distribuídos em dois grupos: Grupo 1 -ratas controle (n = 15) e Grupo 2 -ratas diabéticas (n = 15). O diabetes foi induzido pela aloxana e confirmado pela glicemia ≥250 mg/dL. O índice de peroxidação lipídica, medido pela concentração de SRAT, demonstrou um aumento significativo (p<0.05) nos animais diabéticos, em relação aos animais controle. Entretanto, o parâmetro de defesa antioxidante, mensurado pelo conteúdo de GSH, foi reduzido significativamente (p<0.05) nos animais diabéticos. As análises histomorfométricas mostraram um aumento significativo (p<0.05) da separação trabecular do fêmur, associado à diminuição significativa da espessura trabecular (p<0.05) e volume ósseo trabecular reduzido nas ratas diabéticas. Além disso, o teste biomecânico, V.M.G. Duarte, A. de S. Rodrigues, L.A. de Rezende, A.Ma. de O. Ramos, R.M. de Souza, F.P.F. Neto, A. da C. Medeiros 540 medido pela força máxima, e val...

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Section: Discussionmentioning

confidence: 98%

Relationship between oxidative stress and diabetic osteopenia in premenopausal rats

Duarte

Rodrigues

Rezende

et al. 2010

Braz. J. Pharm. Sci.

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“…A negative influence of type 1 diabetes on bone has been observed in a number of case-control studies conducted in adults [2,22] as well as in children and adolescents [1,4,6,[23][24][25], where peripheral and axial DXA and QCT were employed. It has been suggested that observed differences in adults may result from mineralisation disorders, which operate during rapid skeletal development in puberty.…”

Section: Discussionmentioning

confidence: 99%

Bone status in adolescents with type 1 diabetes

Chobot¹,

Haffke

Polańska

et al. 2010

Diabetologia

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Aims The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other diseaserelated and growth variables was analysed. Methods Group I consisted of 99 pubertal (Tanner ≥2) adolescents (49 female No correlation between Ad-SoS SDS and sex, DIR or diabetes duration was observed. The lower Ad-SoS SDS reflects reduced bone status, and the reduction was significantly more marked in those patients whose HbA 1c T was higher than 7.0% when compared with those whose HbA 1c T was lower. Conclusions Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent on long-term metabolic control.

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“…Correspondingly, T1-diabetes is a risk factor for fractures [Bouillon, 1991;Meyer et al, 1993;Forsen et al, 1999;Schwartz et al, 2001] and delayed fracture healing [Herskind et al, 1992;Folk et al, 1999;White et al, 2003]. Bone loss (at the radius and femur) and hip fracture risk are evident in both male and female T1-diabetics [Auwerx et al, 1988;Buysschaert et al, 1992;Miao et al, 2005;Hadjidakis et al, 2006;Strotmeyer et al, 2006]. However, the influence of gender on diabetic vertebral BMD is inconsistent, with reports indicating suppression only in males [Hadjidakis et al, 2006;Strotmeyer et al, 2006] or only in females [Auwerx et al, 1988].…”

Section: T1-diabetes-human Bone Pathologymentioning

confidence: 99%

“…Bone loss (at the radius and femur) and hip fracture risk are evident in both male and female T1-diabetics [Auwerx et al, 1988;Buysschaert et al, 1992;Miao et al, 2005;Hadjidakis et al, 2006;Strotmeyer et al, 2006]. However, the influence of gender on diabetic vertebral BMD is inconsistent, with reports indicating suppression only in males [Hadjidakis et al, 2006;Strotmeyer et al, 2006] or only in females [Auwerx et al, 1988]. Oral contraceptive use in women may offer some protection against T1-diabetic bone loss [Lunt et al, 1998;Hofbauer et al, 2007] and may contribute to study variability.…”

Section: T1-diabetes-human Bone Pathologymentioning

confidence: 99%

Understanding the pathology and mechanisms of type I diabetic bone loss

McCabe

2007

J of Cellular Biochemistry

213

183

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Type I (T1) diabetes, also called insulin dependent diabetes mellitus (IDDM), is characterized by little or no insulin production and hyperglycemia. One of the less well known complications of T1-diabetes is bone loss which occurs in humans and animal models. This complication is receiving increased attention because T1-diabetics are living longer due to better therapeutics, and are faced with their existing health concerns being compounded by complications associated with aging, such as osteoporosis. Both male and female, endochondrial and intra-membranous, and axial and appendicular bones are susceptible to T1-diabetic bone loss. Exact mechanisms accounting for T1-diabetic bone loss are not known. Existing data indicate that the bone defect in T1-diabetes is anabolic rather than catabolic, suggesting that anabolic therapeutics may be more effective in preventing bone loss. Potential contributors to T1-diabetic suppression of bone formation are discussed in this review and include: increased marrow adiposity, hyperlipidemia, reduced insulin signaling, hyperglycemia, inflammation, altered adipokine and endocrine factors, increased cell death, and altered metabolism. Differences between T1-diabetic- and age-associated bone loss underlie the importance of condition specific, individualized treatments for osteoporosis. Optimizing therapies that prevent bone loss or restore bone density will allow T1-diabetic patients to live longer with strong healthy bones.

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Bone mineral density of both genders in Type 1 diabetes according to bone composition

Cited by 70 publications

References 22 publications

Relationship between oxidative stress and diabetic osteopenia in premenopausal rats

Relationship between oxidative stress and diabetic osteopenia in premenopausal rats

Bone status in adolescents with type 1 diabetes

Understanding the pathology and mechanisms of type I diabetic bone loss

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