Bone Mineral Density in Young Females With Juvenile Idiopathic Arthritis

Povoroznyuk, Vladyslav; Dzhus, Marta

doi:10.25298/2221-8785-2018-16-2-147-151

Cited by 2 publications

(3 citation statements)

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“…According to the results of studies of the structural and functional state of bone tissue, OP was found in 1 % of men aged 20-29 years in Ukraine [22], however, in our study OP in patients with JIA was detected in 8-24 % of patients at different sites of the skeleton, which is significantly higher than in general population. Comparing similar data studies, osteopenic BMD reductions by the Z-score and T-score at the levels of L 1 -L 4 , femoral neck, and ultradistal radius were found more frequently in young women with JIA [2], while osteopenia by T-score in total body was found in 24 % of observed men versus 15 % in women, accor ding to our previous studies [3]. On the one hand, this difference may be due to a small group of male patients that are included in the study.…”

Section: Discussionsupporting

confidence: 89%

“…This disease includes different forms of arthritis of unknown etiology (other than rheumatoid arthritis), begins at the age under 16, often continues in adulthood [1] and can affect the formation of BMD, due to a prolonged administration of glucocorticoids and chronic systemic inflammation. In previous studies, we examined BMD in women with JIA, where it was shown that the presence of JIA in childhood affects the formation of peak bone mass in female and leads to a decrease in BMD in adults requiring active monitoring and preventive therapy in childhood and, if necessary, adult treatment for prevention of osteoporotic complications [2,3]. Diagnosis and treatment of OP in young people aged 20-45 years remain insufficiently studied.…”

Section: Introductionmentioning

confidence: 99%

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Мінеральна Щільність Кісткової Тканини, Показники T Та Z У Молодих Чоловіків З Ювенільним Ідіопатичним Артритом

Povoroznyuk¹,

Dzhus²

2021

PJS

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Bone mineral density, T-and Z-scores in young men with juvenile idiopathic arthritis Abstract. Background. Juvenile Idiopathic Arthritis (JIA) is a term used to classify a group of heterogeneous pediatric rheumatic diseases. Many of these conditions persist through adulthood. Presence of chronic inflammatory disease along with a glucocorticoid treatment is the risk factor of osteoporosis in young adult males. The purpose was to study the bone mineral density (BMD), T-and Z-scores in young adult males with JIA. Materials and methods. The study included 50 patients aged 19-25 years, divided into two groups: I -25 apparently healthy young males; ІІ -25 young men from different regions of Ukraine with a history of JIA in childhood, regardless of the presence or absence of active inflammation at the time of the observation. Two-energy X-ray densitometry (Prodigy, GE Lunar, Madison, USA) was performed at the D.F. Chebotarev Institute of Gerontology, Ukrainian Scientific-Medical Centre for the Problems of Osteoporosis, together with analysis of BMD, T-and Z-scores at different skeletal areas. Results. Young men with JIA and healthy individuals did not differ in age, height, weight and body mass index. Four patients with JIA (16 %) had fractures, while in the control group, there were no fractures. Negative impact of the JIA on the BMD was found in group II compared to group I. Lumbar spine BMD in group II was lower (p < 0.01) than in healthy subjects, as well as the Z-score (p < 0.001) in the L1-L4 lumbar spine region. BMD, T-and Z-scores in femoral neck region were lower in group II than in group I (p < 0.001; p < 0.001; p < 0.01, respectively). Significant differences between the two groups were found in total body BMD (p < 0.001), T-score (p < 0.01), Z-score (p < 0.05). Patients with JIA had lower BMD (p < 0.01) and T-score (p < 0.05) of the ultradistal radius. Decrease of BMD up to the level of osteopenia (Z-score < -2 SD) was found in 20 % patients at the level of L1-L4 lumbar spine, in 8 % -at femoral neck, in 12 % -at total body and in 8 % patients at the level of ultradistal radius. Conclusions. Young men with JIA aged 19-25 years had reduced total body BMD, T-and Z-scores, which indicate the negative impact of the disease on the bone tissue compared with healthy men of the corresponding age.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Мінеральна Щільність Кісткової Тканини, Показники T Та Z У Молодих Чоловіків З Ювенільним Ідіопатичним Артритом

Povoroznyuk¹,

Dzhus²

2021

PJS

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“…Çà ðåçóëüòàòàìè âèùåíàâåäåíèõ äàíèõ òà ïîïåðåäíüî îïóáë³êîâàíèõ íàøèõ ðåçóëüòàò³â îáñòåaeåííÿ [4] ïàö³ºíò³â íà àëåêñèòèì³þ çà îïèòóâàëüíèêîì TAS-20 [5] òà ñòàíó ì³íåðàëüíî¿ ù³ëüíîñò³ ê³ñòêîâî¿ òêàíèíè (ÌÙÊÒ) ó îáñòåaeåíèõ íàìè äîðîñëèõ ïàö³ºíò³â ç Þ²À [3], ìè ðîçðîáèëè àëãîðèòìè âåäåííÿ äîðîñëèõ ïàö³ºíò³â ç Þ²À ïîçèòèâíèõ çà ÐÔ ÷è/òà À-ÖÖÏ (ðèñ. 1).…”

Section: òàáëèöÿ 2 çàãàëüíà êë³í³÷íà õàðàêòåðèñòèêà ïàö³ºíò³â ç ïîë³àðòèêóëÿðíèìè âàð³àíòàìè þ²à çàëåAeíî â³ä ðîçâèòêó ñóãëîáîâèõ òà ïîçàunclassified

Сlinical and Laboratory Data and Algorithm of Management of Adult Patients With Polyarticular Variant of Juvenile Idiopathic Arthritis

et al. 2019

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Relevance. The polyarticular variant of juvenile idiopathic arthritis (JIA) is a disease that begins in childhood and leads to joint damage and disability in adulthood with significant social losses. At 18, patients go under the supervision of adult rheumatologists, often accompanied by loss of control of the disease due to insufficient compliance from both the patient and the physician. Today, there is no documented process for the transfer of patients from childhood to adulthood in Ukraine. Therefore, creating an algorithm for managing such patients is an urgent task.The polyarticular variant of JIA is a disease that begins in childhood and leads to joint damage and disability in adulthood with significant social losses. Objective of this study was to evaluate the clinical and laboratory status and to develop an algorithm for managing adult patients with polyarticular variant of JIA, depending on the detection of RF or/and A-CCP. Materials and methods. The study included 168 adult patients from different regions of Ukraine who were diagnosed with JIA in childhood between 1984 and 2014 without severe comorbidities. Inclusion criteria were: 16 to 60 years old; duration of the disease more than 3 years; the presence of documentary evidence of childhood diagnosis of JIA (ambulatory card, hospital records). Among patients with JIA were identified 53 patients with polyarticular variant, of whom 42 or 25% - with RF (-) polyarthritis and 11 or 6.5% - with RF (+) polyarthritis. The disease activity was evaluated by DAS28 and JADAS-10. The questionaries SF-36, HAQ, TAS-20, PHQ-9 were analyzed and remote articular JADI-A and extra-articular JADI-E damages were evaluated. Statistical studies were performed using IBM SPPS Statistics version 25.0.0.0 software, the results were considered to be reliable at 5% critical level (P <0.05). Results. The negative correlation of JADI-A and the patient's physical well-being PCS (r = -0.27, p <0.05) and physical functioning (r = -0.24, p < 0.05), pain intensity (r = -0.24, p <0.05), general health (r = -0.24, p <0.05), vital activity (r = -0, 19, p <0,05), social functioning (r = -0,27, p <0,05), mental health (r = -0,22, p <0,05) according to SF-36. The severity of extra-articular damages JADI-E correlated with PCS (r = -0.22, p <0.05) and physical functioning (r = -0.28, g <0.05), pain intensity (r = -0.20, p <0.05), general health (r = -0.23, p <0.05), and mental health (r = -0.23, p <0.05), but also had a positive rcorrelation with HAM-A (r = 0.25, p <0.05), depression scale (r = 0.28, p <0, 05) and PHQ-9 (r = 0.28, p <0.05). Significantly lower level of physical health was established in patients who requires prosthetics (p <0.001) compared to those who did not need prosthetics. Conclusion. Based on the results obtained, algorithms for managing adult patients with JIA positive for RF or / and A-CCP were developed, depending on the detected articular and extra-articular damages and the need for prosthetics and the psychological status.

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Bone Mineral Density in Young Females With Juvenile Idiopathic Arthritis

Cited by 2 publications

References 2 publications

Мінеральна Щільність Кісткової Тканини, Показники T Та Z У Молодих Чоловіків З Ювенільним Ідіопатичним Артритом

Мінеральна Щільність Кісткової Тканини, Показники T Та Z У Молодих Чоловіків З Ювенільним Ідіопатичним Артритом

Сlinical and Laboratory Data and Algorithm of Management of Adult Patients With Polyarticular Variant of Juvenile Idiopathic Arthritis

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