Bone mineral density in patients with systemic sclerosis

Frediani, Bruno; Baldi, Fabio; Falsetti, Paolo; Acciai, Caterina; Filippou, Georgios; Spreafico, Adriano; Chellini, Federico; Capperucci, Caterina; Filipponi, P; Galeazzi, Mauro; Marcolongo, Roberto

doi:10.1136/ard.2003.011064

Cited by 31 publications

(40 citation statements)

References 6 publications

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“…Frediani et al . pointed out that SSc patients have reduced BMD of lumbar spine and femoral neck mainly in the diffuse form and in those with internal organ involvement.…”

Section: Discussionmentioning

confidence: 99%

The association between systemic sclerosis and bone mineral density- a meta-analysis of observational studies

et al. 2014

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Previous research has shown inconsistent effect of systemic sclerosis (SSc) on bone mineral density (BMD). The objective of this study was to perform a meta-analysis of previous articles to investigate the differences in BMD (g/cm(2) ) between SSc and non-SSc populations and to discuss potential underlying mechanisms. Twelve full-text articles (including an outlier study and two studies with identical data) with 662 SSc patients and 886 controls were identified by searching Medline prior to 10 September, 2013 using search terms 'Systemic sclerosis' OR 'scleroderma' and 'osteoporosis' OR 'bone density' OR 'bone mass'. BMD (mean and standard deviation), T-scores and Z-scores at lumbar spine, femoral neck and total hip measured by dual-energy X-ray absorptiometry were extracted. Meta-analysis showed that a lower level of BMD was found in SSc patients, with weighted mean difference of -0.343 (95% CI: -0.500 to -0.186) at femoral neck, -0.084 (95% CI: -0.110 to -0.057) at total hip and -0.104 (95% CI: -0.135 to -0.073) at the lumbar spine. We conclude that patients with SSc may have a lower BMD level than healthy controls.

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“…Frediani et al . pointed out that SSc patients have reduced BMD of lumbar spine and femoral neck mainly in the diffuse form and in those with internal organ involvement.…”

Section: Discussionmentioning

confidence: 99%

The association between systemic sclerosis and bone mineral density- a meta-analysis of observational studies

et al. 2014

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“…Theoretically, patients with SSc may have an increased risk of OP as a result of a chronic inflammatory state, occult malabsorption or malnutrition, immobilization, and use of corticosteroid therapy. However, results regarding the risk of OP in SSc are still conflicting in SSc, since previous studies involved different SSc populations, study designs, and generally a relatively small sample size (3, 9–14). Therefore, we aimed to investigate whether patients with SSc have an increased risk of OP and fractures compared to a high‐risk population with RA (positive controls) and a population of healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Increased risk of osteoporosis and fracture in women with systemic sclerosis: A comparative study with rheumatoid arthritis

Avouac¹,

Koumakis²,

Tóth³

et al. 2012

Arthritis Care & Research

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Objective. To investigate whether women with systemic sclerosis (SSc) have an increased risk of osteoporosis (OP) and related fractures compared to a high-risk population with rheumatoid arthritis (RA) and also healthy controls, and to determine putative specific OP and fracture risk factors. Methods. We performed a cross-sectional study with successive inclusion of age-matched healthy women and women with SSc and RA. Risk factors for OP and fracture were collected for all patients. Bone mineral density (BMD) was systematically measured at the lumbar spine and total hip region with dual x-ray absorptiometry.

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“…Полученные результаты убедительно показали достоверное снижение МПКТ у больных ССД по сравнению с контрольной группой. Эти данные согласуются с результатами большинства исследований МПКТ у больных ССД и были вполне ожидаемыми [7,[12][13][14][15][16][17]. В частности, в обзоре M. Omair и соавт.…”

Section: Discussionunclassified

“…При этом в группе больных сниженная МПКТ в ШБК и ВПОБК встречалась достоверно чаще, чем у жен-таблица 2. МПКт и т-критерий у больных ССД и в контрольной группе (M±sd) [5,12].…”

Section: Discussionunclassified

“…В этом исследовании мы не обнаружили корреляции МПКТ с возрастом больных, хотя во многих работах выявлена обратная связь этих параметров [12,14,16,17]. Возможно это связано с относительно небольшими возрастными рамками включенных в наше исследование женщин.…”

Section: Discussionunclassified

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