Bone Mineral Density in Mild and Advanced Ankylosing Spondylitis

Çapaci, Kazım; Hepgüler, Simin; Argın, Mehmet; Taş, Işıl

doi:10.3349/ymj.2003.44.3.379

Cited by 42 publications

(34 citation statements)

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“…In spite of bony growth in ankylosing spondylitis osteoporosis of the lumbar spine was found in up to 34.3% and osteoporosis of the hip in up to 29% patients [37][38][39][40][41][42]. Moreover, Capaci et al found that even 61.6% of patients with mild AS had spinal osteoporosis and osteopenia, while 46.6% had osteoporosis and osteopenia at the total hip [43].…”

Section: Discussionmentioning

confidence: 99%

Osteoporosis in psoriatic arthritis: Is there any?

Grazio

Cvijetić

Vlak

et al. 2011

Wien Klin Wochenschr

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Aims: Although considered as a feature of inflammatory rheumatic diseases, there is a lot of controversy around low bone mass in patients with psoriatic arthritis. The aim of this cross-sectional study was to analyze bone mineral density in patients with psoriatic arthritis, as well as to investigate its possible association with some measures of disease activity and functional capacity. Subjects and Methods:Sixty-nine patients with established psoriatic arthritis (mean age 56.20±12.23 years) and who has not been treated with specific antiosteoporotic drugs were recruited from the outpatient clinic database. Bone mineral density was measured by dual-energy X-ray absorptiometry at the lumbar spine and at the left hip. Disease activity measures included: duration of morning stiffness, tender and swollen joint count, patient's and physician's global assessment, presence of dactylitis and enthesitis, ESR, CRP and Disease Activity Score 28. Health Assessment Questionnaire was used to assess functional status.Results: According to WHO definition, spinal osteoporosis was found in 7.2% of patients, total hip osteoporosis in 1.4% of patients and femoral neck osteoporosis in 2.9% of patients. There was no significant association of any of the measures of disease activity with BMD at any site. Higher HAQ scores were associated with lower total hip BMD.Conclusions: In our sample of patients with psoriatic arthritis we did not find increased prevalence of osteoporosis. There was no association of BMD with indices of disease activity, while negative correlation was found between HAQ and total hip BMD.

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Section: Discussionmentioning

confidence: 99%

Osteoporosis in psoriatic arthritis: Is there any?

Grazio

Cvijetić

Vlak

et al. 2011

Wien Klin Wochenschr

View full text Add to dashboard Cite

show abstract

“…So, consistently with our study other investigators also found higher prevalence of osteoporosis of the spine compared to the hip region. Capaci et al found that even 61.6% of patients with mild AS had spinal osteoporosis and osteopenia, while 46.6% had osteoporosis and osteopenia at the total hip [34].…”

Section: Discussionmentioning

confidence: 99%

Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

et al. 2011

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SummaryAim. In ankylosing spondylitis (AS) inflammatory activity probably plays a key role in the pathophysiology of bone loss. The aim of the study was to investigate the relationship of bone mineral density (BMD) at the lumbar spine and hip region with some measures of disease activity and functional ability in patients with ankylosing spondylitis.Methods: In 80 patients with established ankylosing spondylitis disease activity and functional ability were determined by C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). Spinal pain and patient global health were assessed using horizontal visual analogue scale (VAS). BMD was measured by dual-energy x-ray absorptiometry (DXA).Results. There was a significant negative correlation of bone density T scores with acute phase reactants (i.e. patients with lower T scores had higher level of CRP and ESR). That relationship was reflected more reliably at proximal femur sites than at the lumbar spine.There were also significant differences in ESR, BASDAI, BASFI, spinal pain and global health between three groups of patients according to WHO classification of osteoporosis (normal, osteopenic and osteoporotic). Significantly more patients with osteopenia at the lumbar spine had lower BASDAI index than those with normal BMD (p=0.030). Conclusion:Our results indicate an association of low BMD with high disease activity in patients with AS. Femoral BMD seems to be more associated with disease activity and functional ability than lumbar spine BMD.

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“…K. Capaci and colleagues has proved that disease activity rated by physician on the basis of radiological signs of vertebral and hip destruction extent has no influence on the bone mass of AS patients (Capaci et al, 2003). Other authors have made similar conclusions to proving that acute inflammatory phase markers found once do not forecast either progression of radiological signs of SpA or reduction of BMD in different parts of skeleton.…”

Section: Discussionmentioning

confidence: 92%