Bone Mineral Density and Type 1 Diabetes in Children and Adolescents: A Meta-analysis

Loxton, Phoebe; Narayan, Kruthika; Munns, Craig F; Craig, Maria E.

doi:10.2337/dc20-3128

Cited by 19 publications

(11 citation statements)

References 37 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A Korean study ( 27 ) found that obese children and adolescents with T2D had significantly lower BMD Z-scores at the femoral neck compared with age-, sex-, and BMI-matched controls. A meta-analysis ( 28 ) also indicated that children and adolescents with type 1 diabetes (T1D) had lower BMD than controls. Hence, peak bone mass in youth with prediabetes and diabetes might be influenced by the deterioration of bone mineral accruals.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Bone Mineral Density in US Adults With Diabetes, Prediabetes and Normoglycemia From 2005 to 2018

2022

View full text Add to dashboard Cite

BackgroundAccumulating evidence has shown that diabetes has an impact on bone metabolism with conflicting results. Furthermore, little is known about the relationship of prediabetes with bone mineral density (BMD). Therefore, we explored the association between BMD and glucometabolic status in adults in the US.MethodsIn this cross-sectional study, we extracted and analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. A total of 14610 subjects aged 40 ≥ years diagnosed with diabetes, prediabetes, or normal glucose regulation (NGR) and had available data on BMD were eligible.ResultsThe prevalence of prediabetes and diabetes in US adults aged 40 ≥ years were 39.2% and 26.4%, respectively. After multivariable adjustment, we found an increasing trend of BMD at the total hip, femoral neck, and lumbar spine with glucometabolic conditions from NGR and prediabetes to diabetes in adults aged ≥ 40 years in the US. This trend was more prominent in women than that in men. Fasting plasma glucose (FPG) and HbA1c levels were also positively correlated with BMD.ConclusionsGlucometabolic conditions were significantly associated with BMD values in US adults.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of Bone Mineral Density in US Adults With Diabetes, Prediabetes and Normoglycemia From 2005 to 2018

2022

View full text Add to dashboard Cite

show abstract

“…Higher body fat may also relate to the skeletal deficits in children with T1D (9). Children with T1D have lower bone mass (i.e., mineral content and areal bone mineral density) along with altered trabecular density and micro-architecture (e.g., trabecular thickness) according to meta-analyses (43)(44)(45). Recent evidence suggested that body fat % was negatively associated with total body bone mineral content and areal bone mineral density in children (9).…”

Section: Discussionmentioning

confidence: 99%

Higher Body Fat in Children and Adolescents With Type 1 Diabetes–A Systematic Review and Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

AimsHigher prevalence of overweight and obesity in children and adolescents with type 1 diabetes (T1D) suggests alterations are required in body composition. However, differences in body composition between children with T1D and typically developing children (TDC) have not been synthesized using meta-analysis. Therefore, we conducted a systematic review and meta-analysis to compare body composition between children with T1D and TDC, and to explore the role of disease and non-disease related factors in potential body composition differences.MethodsStudies were performed comparing dual-energy x-ray absorptiometry-acquired total body fat and lean mass, absolute (kg) and relative (%) values, between children with T1D and TDC. We reported mean differences with 95% confidence intervals (CI) from meta-analysis and relative between-group %-differences. We used meta-regression to explore the role of sex, age, height, body mass, body mass index, Hemoglobin A1c, age of onset, disease duration, and insulin dosage in the potential body composition differences between children with T1D and TDC, and subgroup analysis to explore the role of geographic regions (p < 0.05).ResultsWe included 24 studies (1,017 children with T1D, 1,045 TDC) in the meta-analysis. Children with T1D had 1.2 kg more fat mass (kg) (95%CI 0.3 to 2.1; %-difference = 9.3%), 2.3% higher body fat % (0.3–4.4; 9.0%), but not in lean mass outcomes. Age of onset (β = −2.3, −3.5 to −1.0) and insulin dosage (18.0, 3.5–32.6) were negatively and positively associated with body fat % mean difference, respectively. Subgroup analysis suggested differences among geographic regions in body fat % (p < 0.05), with greater differences in body fat % from Europe and the Middle East.ConclusionThis meta-analysis indicated 9% higher body fat in children with T1D. Earlier diabetes onset and higher daily insulin dosage were associated with body fat % difference between children with T1D and TDC. Children with T1D from Europe and the Middle East may be more likely to have higher body fat %. More attention in diabetes research and care toward body composition in children with T1D is needed to prevent the early development of higher body fat, and to minimize the cardiovascular disease risk and skeletal deficits associated with higher body fat.

show abstract

“…Many studies indicate that the BMD of T1DM patients is reduced, while the BMD of T2DM patients is controversial [18,19]. Additionally, the hip fracture risk of T1DM is twofold-fivefold of the T2DM patients [20].…”

Section: Discussionmentioning

confidence: 99%

A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism

Xia

Wang

et al. 2022

J Orthop Surg Res

View full text Add to dashboard Cite

Background Osteoporosis (OP) patients complicated with type II diabetes mellitus (T2DM) has a higher fracture risk than the non-diabetic patients, and mesenchymal stem cells (MSCs) from T2DM patients also show a weaker osteogenic potent. The present study aimed to provide a gene expression profile in MSCs from diabetic OP and investigated the potential mechanism. Methods The bone-derived MSC (BMSC) was isolated from OP patients complicated with or without T2DM (CON-BMSC, T2DM-BMSC). Osteogenic differentiation was evaluated by qPCR analysis of the expression levels of osteogenic markers, ALP activity and mineralization level. The differentially expressed genes (DEGs) in T2DM-BMSC was identified by RNA-sequence, and the biological roles of DEGs was annotated by bioinformatics analyses. The role of silencing the transcription factor (TF), Forkhead box Q1 (FOXQ1), on the osteogenic differentiation of BMSC was also investigated. Results T2DM-BMSC showed a significantly reduced osteogenic potent compare to the CON-BMSC. A total of 448 DEGs was screened in T2DM-BMSC, and bioinformatics analyses showed that many TFs and the target genes were enriched in various OP- and diabetes-related biological processes and pathways. FOXQ1 had the highest verified fold change (abs) among the top 8 TFs, and silence of FOXQ1 inhibited the osteogenic differentiation of CON-BMSC. Conclusions Our study provided a comprehensive gene expression profile of BMSC in diabetic OP, and found that downregulated FOXQ1 was responsible for the reduced osteogenic potent of T2DM-BSMC. This is of great importance for the special mechanism researches and the treatment of diabetic OP.

show abstract

Bone Mineral Density and Type 1 Diabetes in Children and Adolescents: A Meta-analysis

Cited by 19 publications

References 37 publications

Comparison of Bone Mineral Density in US Adults With Diabetes, Prediabetes and Normoglycemia From 2005 to 2018

Comparison of Bone Mineral Density in US Adults With Diabetes, Prediabetes and Normoglycemia From 2005 to 2018

Higher Body Fat in Children and Adolescents With Type 1 Diabetes–A Systematic Review and Meta-Analysis

A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism

Contact Info

Product

Resources

About