Bone mineral density and risk of fractures in aging, obese post-menopausal women with type 2 diabetes. The GIUMO Study

Sosa, Manuel; Saavedra, Pedro; Jódar, Esteban; Lozano-Tonkin, C; Quesada, J. M.; Torrijos, A.; Pérez‐Cano, Ramón; Nogués, Xavier; Díaz-Curiel, Manuel; Moro, M. J.; Gómez, Carlos García; Mosquera, J. M.; Alegre, J; Olmos, José M.; Muñóz-Torres, Manuel; Guañabens, Núria; Pino, Javier del; Hawkins, Federico

doi:10.1007/bf03324895

Cited by 36 publications

(36 citation statements)

References 38 publications

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“…In some studies, T2D was not associated with fractures [211, 298, 299]; in other studies T2D even tended to be protective [300, 301] although the latter result was not significant either on initial report or when reanalyzed in meta-analyses. Interestingly, those studies which resulted only in minimal increase in fracture risk involved mainly diet controlled [291, 302] or early onset T2D.…”

Section: Diabetes and Fractures In Clinical Practicementioning

confidence: 99%

The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes

Napoli

Strollo

Paladini

et al. 2014

International Journal of Endocrinology

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Bone fragility has emerged as a new complication of diabetes. Several mechanisms in diabetes may influence bone homeostasis by impairing the action between osteoblasts, osteoclasts, and osteocytes and/or changing the structural properties of the bone tissue. Some of these mechanisms can potentially alter the fate of mesenchymal stem cells, the initial precursor of the osteoblast. In this review, we describe the main factors that impair bone health in diabetic patients and their clinical impact.

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Section: Diabetes and Fractures In Clinical Practicementioning

confidence: 99%

The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes

Napoli

Strollo

Paladini

et al. 2014

International Journal of Endocrinology

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“…The most prevalent of these includes COPD, type I diabetes mellitus, hyperthyroidism, and rheumatoid arthritis. Many references are made in published articles [24][25][26][27] to the role of these diseases as facilitators of secondary osteoporosis.…”

Section: Risk Factor Prevalencementioning

confidence: 99%

Assessing osteoporosis risk factors in Spanish menopausal women

Pérez

Palacios

García³

et al. 2010

Gynecological Endocrinology

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“…Moreover, among the whole study population, the stroke patients showed the highest bone density values for the nonparetic side. The nonparetic side of stroke patients is exposed to greater weight bearing input and to excessive physical activity, causing it to gain greater bone density than that of the healthy population16, 17 ) . Increased physical activity through functional recovery of hemiplegic patients can be considered important in preventing decreased bone density throughout the whole body.…”

Section: Discussionmentioning

confidence: 99%

“…The World Health Organization has used T scores to define clinical cutoff values for osteoporosis in female adults. A T score of ≥−1.0 is defined as normal; a T score between −1.0 and −2.5, as osteopenia; and a T score of ≤−2.5, as osteoporosis15, 16 ) . This study defined the change in bone density as the difference in bone density between the paretic and nonparetic sides in the stroke group, and between the dominant and nondominant sides in the control group.…”

Section: Methodsmentioning

confidence: 99%

Comparison of bone density on the dominant and nondominant sides between healthy elderly individuals and stroke patients

et al. 2016

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[Purpose] This study evaluated differences between healthy elderly individuals and stroke patients by comparing their dominant and nondominant sides. [Subjects and Methods] Thirty-five elderly individuals participated in this study and divided into a stroke group and a control group. The outcome measures were general characteristics and bone mineral density. Bone mineral density was evaluated by using the osteoporosis index. OsteoPro, T score, and Z score were used for the calcaneus region of the dominant side, and OsteoPro was used for that of the nondominant side. Data were analyzed by using the SPSS 12.0 software, paired-samples t-test, and independent-samples t-test. [Results] The T and Z scores showed no significant differences between the dominant and recessive sides in the control group. However, the stroke group showed significant differences in osteoporosis index, T score, and Z score between the paretic and nonparetic sides. Changes in the scores between the recessive and dominant sides showed significant differences between the two groups. [Conclusion] A positive relationship was found between physical activity and bone mineral density in the stroke patients. Therefore, improved physical activity can be beneficial by reducing osteoporosis in stroke patients.

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Bone mineral density and risk of fractures in aging, obese post-menopausal women with type 2 diabetes. The GIUMO Study

Abstract: In obese postmenopausal Caucasian women, type 2 DM produces an increase in BMD of the lumbar spine without changes in BMD of the proximal femur or in QUS measurements of the heel. The prevalence of vertebral, hip and non-vertebral fractures did not increase in type 2 DM.

Cited by 36 publications

References 38 publications

The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes

The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes

Assessing osteoporosis risk factors in Spanish menopausal women

Comparison of bone density on the dominant and nondominant sides between healthy elderly individuals and stroke patients

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