The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes

Napoli, Nicola; Strollo, Rocky; Paladini, A; Briganti, Silvia; Pozzilli, Paolo; Epstein, Sol

doi:10.1155/2014/690783

Cited by 76 publications

(60 citation statements)

References 346 publications

(431 reference statements)

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“…(34) Each participant's scan included a calibration standard of three hydroxyapatite concentrations (150, 75, and 0 mg/cm 3 ). Images were converted from the native scanner Hounsfield Units (HU) to equivalent concentration (g/cm 3 ) of calcium hydroxyapatite contained in the calibrations standard. Lumbar spine images were acquired using settings of 120 kVp, 150 mA, 1 mm slice thickness, 512 Â 512 matrices, and measurement using an anatomical region 5 mm above the L 1 superior endplate to 5 mm below the L 2 inferior endplate.…”

Section: Methodsmentioning

confidence: 99%

Vertebral Fracture Risk in Diabetic Elderly Men: The MrOS Study

Napoli

Schwartz²,

Schafer

et al. 2017

Journal of Bone and Mineral Research

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Type 2 diabetes (T2DM) is associated with a significant increase in risk of nonvertebral fractures, but information on risk of vertebral fractures (VFs) in subjects with T2DM, particularly among men, is lacking. Furthermore, it is not known whether spine bone mineral density (BMD) can predict the risk of VF in T2DM. We sought to examine the effect of diabetes status on prevalent and incident vertebral fracture, and to estimate the effect of lumbar spine BMD (areal and volumetric) as a risk factor for prevalent and incident morphometric vertebral fracture in T2DM (n ¼ 875) and nondiabetic men (n ¼ 4679). We used data from the Osteoporotic Fractures in Men (MrOS) Study, which enrolled men aged !65 years. Lumbar spine areal BMD (aBMD) was measured with dual-energy X-ray absorptiometry (DXA), and volumetric BMD (vBMD) by quantitative computed tomography (QCT). Prevalence (7.0% versus 7.7%) and incidence (4.4% versus 4.5%) of VFs were not higher in T2DM versus nondiabetic men. The risk of prevalent (OR, 1.05; 95% CI, 0.78 to 1.40) or incident vertebral-fracture (OR, 1.28; 95% CI, 0.81 to 2.00) was not higher in T2DM versus nondiabetic men in models adjusted for age, clinic site, race, BMI, and aBMD. Higher spine aBMD was associated with lower risk of prevalent VF in T2DM (OR, 0.55; 95% CI, 0.48 to 0.63) and nondiabetic men (OR, 0.66; 95% CI, 0.5 to 0.88) (p for interaction ¼ 0.24) and of incident VF in T2DM (OR, 0.50; 95% CI, 0.41 to 0.60) and nondiabetic men (OR, 0.54; 95% CI, 0.33 to 0.88) (p for interaction ¼ 0.77). Results were similar for vBMD. In conclusion, T2DM was not associated with higher prevalent or incident VF in older men, even after adjustment for BMI and BMD. Higher spine aBMD and vBMD are associated with lower prevalence and incidence of VF in T2DM as well as nondiabetic men.

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Section: Methodsmentioning

confidence: 99%

Vertebral Fracture Risk in Diabetic Elderly Men: The MrOS Study

Napoli

Schwartz²,

Schafer

et al. 2017

Journal of Bone and Mineral Research

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“…These results suggest that the mechanisms identified in the rodent models may remain relevant in humans. On the contrary, studies evaluating the other interventions, which are capable of changing osteocalcin levels, have reported opposite results questioning the crosstalk between osteocalcin and glucose metabolism in humans . For instance, Choi et al demonstrated that supplementation of vitamin K 2 for 4 weeks, which reduces ucOC levels, increased insulin sensitivity in healthy young men .…”

Section: Discussionmentioning

confidence: 99%

“…Cross‐sectional clinical studies and longitudinal clinical studies have shown that higher total osteocalcin and ucOC levels are correlated with increased insulin sensitivity, enhanced β‐cell function, and improved glucose tolerance. A higher osteocalcin level or ucOC level is also correlated with less total and visceral fat hence more fat‐free mass, lower glucose levels, and lower body mass index (BMI) . These associations are found across almost all populations studied including patients with T1DM, T2DM, prediabetes, gestational diabetes, metabolic syndrome, and obesity as well as healthy individuals .…”

Section: Introductionmentioning

confidence: 88%

“…A growing body of evidence has demonstrated that osteocalcin, produced and secreted by osteoblasts, contributes to regulation of endocrine system homeostasis . Animal studies have revealed that undercarboxylated osteocalcin (ucOC) enhances the expression of insulin genes and insulin production, stimulates β‐cell proliferation, improves glucose homeostasis, and protects against diet‐induced obesity . In addition, ucOC stimulates β‐cell proliferation in cultured human islets .…”

Section: Introductionmentioning

confidence: 99%

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Circulating osteocalcin: A potential predictor of ketosis in type 2 diabetes

Zhu

Lin

Chen

et al. 2020

Diabetes Metabolism Res

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Aims: Osteocalcin contributes to the regulation of endocrine system. However, the association between osteocalcin and ketosis has not been evaluated. We thus aimed to explore the relationship between total osteocalcin and risk of ketosis in type 2 diabetes (T2DM). Materials and methods:We identified 6157 diabetes patients from Shanghai Tenth People's Hospital between 1 January 2011 and 1 March 2017. Six hundred eight subjects were enrolled in the retrospective cross-sectional study: 304 T2DM patients with ketosis whose age, gender, and body mass index were matched with 304 T2DM patients without ketosis. A further retrospective nested case-control study was conducted in 252 T2DM patients without ketosis for a mean duration of 21.58 ± 12.43 months to investigate the occurrence of ketosis. Results: Osteocalcin levels were negatively correlated with blood ketones (adjusted r = −0.263) and urine ketones (adjusted r = −0.183). The inverse dose-dependent relationship of osteocalcin and risk of ketosis was present across osteocalcin level quintiles (top quintile as the reference, adjusted odds ratio [95% CI] = 2.56 [0.80-8.17], 3.71 [0.90-15.29], 10.77 [2.63-44.15], 23.81 [4.32-131.17] per osteocalcin quintile, respectively). Ketosis occurred in 17 of the 252 T2DM patients during follow-up. The Cox regression analysis indicated that osteocalcin was an independent protective factor against development of ketosis (adjusted hazard ratio [95% CI]: 0.668 [0.460-0.971]). Conclusions: Total osteocalcin can be used as a predictor of ketosis in T2DM. K E Y W O R D S ketosis, total osteocalcin, type 2 diabetes Bing Zhu and Ziwei Lin contributed equally as co-first authors.

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“…Primeiro, a adiponectina sinaliza nos osteoblastos, o que evita a sua proliferação e aumenta a apoptose de uma forma dependente da enzima fosfofrutocinase 1 (Fox-1) e fosfoinositídeo 3-quinase ou fosfatidilinositol 3-quinases (PI 3-quinases ou PI3Ks), como resultado diminui a formação óssea, a massa óssea e os níveis de osteocalcina circulantes. No entanto, essas funções são rapidamente mascaradas, porque a adiponectina também possui ação no sitema nervoso simpático no cérebro, através do FoxO1 (forkhead protein-O1), age na sua forma não fosforilada como um fator de transcrição nuclear, assim, inibe a atividade de sua produção no sistema nervoso simpático, aumentando a formação óssea (NAPOLI et al, 2014).…”

Section: Composição Corporal Relacionado a Massa óSseaunclassified

Relação entre índices de gordura corporal e massa óssea em adultos e idosos: estudo ISA - Capital (2014)

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O mestrado foi resultado de uma longa trajetória e fruto de muita dedicação, mas também da participação de diversas pessoas queridas. Registro aqui meus agradecimentos a todos aqueles que, direta ou indiretamente, me apoiaram nessa fase e contribuíram para o desenvolvimento da dissertação de mestrado. Aos meus pais, Maria Iva de Oliveira e Angelo Couceiro, por todo carinho e suporte, conselhos e incentivo nas escolhas profissionais e na paixão pelos estudos. Ao meu irmão Leonardo Couceiro, por ouvir atentamente as dificuldades que se apresentam no caminho daquele que decide estudar e aperfeiçoar-se profissionalmente. Ao Elinaldo C. Santos, meu querido esposo, companheiro, confidente, por compartilhar momentos alegres e de tensão, pela compreensão nas horas mais difíceis e pela paciência nesse período de longo período, fins de semana dedicados a pesquisa em meio a artigos e computadores. Obrigado pelo suporte de informática, instalações e consultoria! Aos meus avós, a avó materna Maria Alves e os paternos Harley e Maria pelo carinho e apoio. Aos tios, especialmente minha tia Aparecida Zanardi e minha tia Dirce que sempre tiveram palavras de motivação e são exemplos de dedicação e motivação em meio as dificuldades. Aos sogros Eliana Valeriana de Brito e Ademir Paixão Santos, bem como, ao cunhado Eliel Brito, cunhada Sandra, Nilton e as gêmeas, bem como, os tios e primos pelo incentivo e momentos descontraídos. A vó do meu esposo Marina Magalhães é uma inspiração aos seus 99 anos de vida, com sabedoria, compreensão e exemplo de vida. A toda a minha família, que sempre me incentivou e compreendeu minha ausência em encontros, especialmente na fase final. Á Lígia A. Martini, professora, supervisora, agradeço pela motivação, por ser um exemplo de superação de limites, pela oportunidade fornecida de fazer parte do grupo de pesquisa e iniciar o Mestrado conciliando a área de docência. Obrigada pelos ensinamentos, por guiar com propostas. Á Prof as Regina Mara Fisberg por autorizar o uso dos dados do estudo ISA-Capital para este estudo, e envolvimento na coleta de dados. Agradeço pelo convívio e aprendizado durante os anos de pósgraduação. Á Bárbara Santarosa Emo Peters, orientadora, pelas correções, propostas e sugestão de tema de pesquisa. Tornou-se amiga, companheira e parceira nesta empreitada. Por ter acreditado no meu potencial, por me acalmar em cada fase e contribuir para me tornar uma pesquisadora melhor. Obrigada pelas conversas e ensinos.

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The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes

Cited by 76 publications

References 346 publications

Vertebral Fracture Risk in Diabetic Elderly Men: The MrOS Study

Vertebral Fracture Risk in Diabetic Elderly Men: The MrOS Study

Circulating osteocalcin: A potential predictor of ketosis in type 2 diabetes

Relação entre índices de gordura corporal e massa óssea em adultos e idosos: estudo ISA - Capital (2014)

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