Bone mineral density and abstention-induced changes in bone and mineral metabolism in noncirrhotic male alcoholics

Laitinen, Kalevi; Lamberg‐Allardt, Christel; Tunninen, Riitta; Härkönen, Matti; Välimäki, Matti

doi:10.1016/0002-9343(92)90197-j

Cited by 104 publications

(84 citation statements)

References 31 publications

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“…The absence of hepatic inflammation and cirrhosis was confirmed by histology; however, bone loss was observed. This observation is consistent with previous reports in humans that demonstrate bone loss in the absence of cirrhosis (37,40). These results demonstrate that ethanol induces bone loss through a mechanism other than nonspecific hepatic inflammation.…”

Section: Tablesupporting

confidence: 93%

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Dai¹,

Lin²,

Zhang³

et al. 2000

J. Clin. Invest.

136

100

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Section: Tablesupporting

confidence: 93%

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Dai¹,

Lin²,

Zhang³

et al. 2000

J. Clin. Invest.

136

100

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“…Diminished BMD has been reported in patients with alcoholic liver disease, [10][11][12][13][14] alcoholic subjects without cirrhosis, 15,16 patients with pri- mary biliary cirrhosis, [3][4][5] and patients with hemochromatosis, 8,9 but little has been published on viral cirrhotic patients without a history of alcohol consumption. In our study, bone densities in the FN and LS were significantly lower in viral cirrhotic patients than in the reference population, and this reduction was more severe in LS (trabecular bone) than FN (cortical bone), probably because the rate of turnover in cortical bone is much lower than in trabecular bone.…”

Section: Discussionmentioning

confidence: 99%

“…Reduced osteoblastic function with diminished bone formation has been suggested as the main factor responsible for osteoporosis in alcoholic subjects with and without cirrhosis. 1,10,16 Factors other than ethanol may be responsible for the bone mass loss in alcoholic liver disease, and in nondrinking viral cirrhotic patients. Previous studies have reported contradictory findings for serum PTH levels in chronic liver disease.…”

Section: Discussionmentioning

confidence: 99%

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Bone mineral density, serum insulin-like growth factor I, and bone turnover markers in viral cirrhosis

et al. 1998

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Previous studies suggest that low bone mass is a complication of alcoholic liver disease. Nevertheless, little is known about bone mass and bone metabolism in viral cirrhosis. To evaluate the prevalence and magnitude of hepatic osteopenia in these patients, bone remodeling status, and its relationship with the severity of liver disease and serum levels of insulin-like growth factor I (IGF-I), we studied 32 consecutive patients with viral cirrhosis and no history of alcohol intake. Bone mineral density (BMD) was measured by dual x-ray absorptiometry in the lumbar spine (LS) and femoral neck (FN), and the values were expressed as the z score. Bone metabolism markers and hormone profiles were measured. Patients with viral cirrhosis showed reduced BMD in all sites (LS: ؊1.27 ؎ 1.06, P F .001; FN: ؊0.48 ؎ 0.96; P F .01). Of the 32 patients, 53% met the diagnostic criteria for osteoporosis. In patients, urine deoxypyridinoline (D-Pyr) as a marker of bone resorption and serum bone alkaline phosphatase (b-AP) as a marker of bone formation were significantly higher than in control subjects (P F .001 and P F .01, respectively). Serum IGF-I was lower than in control subjects (P F .001), and significant differences were also found between patients with and without osteoporosis (P F .05). BMD in LS correlated with severity of the disease, with serum levels of IGF-I, and with urine D-Pyr. Our findings show that viral cirrhosis is a major cause of osteoporosis in men, and that low serum IGF-I levels seem to play a role in the bone mass loss in these patients. The biochemical markers of bone remodeling suggest high-turnover osteoporosis in patients with viral cirrhosis. (HEPATOLOGY 1998;28:695-699.)

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“…Data from experimental studies indicate that osteocalcin (a marker of bone formation) increases after abstinence [33] and decreases after alcohol administration [34].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Relationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumption

Paccou

Edwards

Ward

et al. 2015

Bone

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Relationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumption, Bone (2015), doi: 10.1016/j.bone. 2015.05.002 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and Professor of Musculoskeletal Science, University of Oxford. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT Contact details:MRC Lifecourse Epidemiology Unit, (University of Southampton), socioeconomic status and years since menopause and HRT use for women), men that drank low alcohol had lower cortical thickness (p=0.038), cortical vBMD (p=0.033), and trabecular vBMD (p=0.028) and higher trabecular separation (p=0.043) than those that drank none/minimal alcohol. Similar differences were shown between minimal/none and moderate/high alcohol although these only reached statistical significance for the cortical parameters. Interestingly, after similar adjustment, women showed similar differences in the trabecular compartment between none/minimal alcohol and low alcohol at the distal tibia.However, women that drank moderate/high alcohol had significantly higher trabecular vBMD (p=0.007), trabecular thickness (p=0.026), and trabecular number (p=0.042) and higher trabecular separation (p=0.026) at the distal radius than those that drank low alcohol.Conclusions: Our results suggest that alcohol consumption (low and moderate/high) may have a detrimental impact on bone health in men in both the cortical and trabecular A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT4 compartments at the distal radius with similar results in women in the trabecular compartment between none/minimal alcohol and low alcohol at the distal tibia suggesting that avoidance of alcohol may be beneficial for bone health.Keywords: alcohol consumption, high-resolution peripheral quantitative computed tomography, bone geometry, microarchitecture, volumetric bone mineral density.Highlights:1/ Men that drank low alcohol had lower Ct.Th, Ct.vBMD, Tb.vBMD and higher Tb.Sp at the distal radius than those that drank none/minimal alcohol.2/ Low levels of alcohol consumption are not beneficial for bone health.3/ There is a site-and sex-dependent effect of alcohol consumption on bone health.

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Bone mineral density and abstention-induced changes in bone and mineral metabolism in noncirrhotic male alcoholics

Cited by 104 publications

References 31 publications

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Bone mineral density, serum insulin-like growth factor I, and bone turnover markers in viral cirrhosis

Relationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumption

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