Bone Mineral Analogue Ceramic Block as an Instant Adhesive to Biological Soft Tissue

Abstract

Soft-tissue adhesives are an attractive choice for device immobilization by nonsuturing methods. [8] Three glue-type adhesives have been introduced: cyanoacrylate, [9] gelatin-resorcinol-formaldehyde, [10] and fibrin. [11] Although these materials are easily spread over the entire contact area and infiltrated into ruptured tissues, their biocompatibility (for cyanoacrylate and gelatin-resorcinol-formaldehyde adhesives) or bonding strength (for fibrin adhesives) is limited. [8,12] Another strategy is the attachment of materials with soft-tissue adhesive properties to the implantable devices themselves. Some bone-substitute materials, such as titanium (Ti) and hydroxyapatite with excellent osteoconductivity, also strongly adhere to soft tissues. [13,14] Although the adhesive properties of non-bioresorbable bone-substitute materials are sufficient to immobilize an implantable device, the clinical applicability of these materials is limited by their non-bioresorbable property. In real applications, the device must be both attachable and detachable. Ideally, a material for clinical application should be both strongly adhesive and bioresorbable. Octacalcium phosphate (OCP), a main mineral composite in immature biological bone, [15,16] exhibits excellent biocompatibility and can be replaced by bone through metabolic processes. [17] Furthermore, OCP has good formability into blocks or coating. [18,19] However, the application of OCP as a soft tissue adhesive has never been explored.

Highly stretchable, compressible, adhesive hydrogels with double network

“…6b, and adhesion strength was 35.09 ± 4.01 kPa, 33.32 ± 5.00 kPa, 9.74 ± 4.20 kPa for BSA-PAM-2, BSA-PAM-3 and BSA-PAM-4 hydrogel respectively. For BSA-PAM-2, the adhesion strength was higher than commercial glues such as Bioglueand Fibrin (Table 3) [48][49][50].…”

Solid-state inorganic and metallic adhesives for soft biological tissues

“…In addition to HAp, a porous octacalcium phosphate (OCP) disk was developed by the dissolution–precipitation reaction of calcium hydrogen phosphate in a Na 2 HPO 4 solution [44] . OCP is also biocompatible and can be used as a bone filler for replacing natural bone via metabolic processes [45] .…”

Coatings of hydroxyapatite–bioactive glass microparticles for adhesion to biological tissues

“…Another calcium phosphate based material, the octacalcium phosphate block, was recently shown to adhere strongly ex vivo to mouse dermal tissues. 34 …”

“…Another calcium phosphate based material, the octacalcium phosphate block, was recently shown to adhere strongly ex vivo to mouse dermal tissues. 34 In addition to their potential for tissue adhesion, both HA and BG particles may be interesting to deliver local therapeutic treatments. The ability of the HA lattice to accept ionic substitutions provides a way to insert metallic ions like silver, copper or zinc, which have antibacterial or anti-inammatory effects.…”