Bone Microarchitecture and Stiffness in Premenopausal Women with Idiopathic Osteoporosis

Abstract

Premenopausal women with IOP had marked trabecular microarchitectural deterioration at the radius and tibia. Cortical parameters were affected only at the tibia. Although they had not fractured, microarchitectural deterioration was similar in IOP women with low BMD and those with fractures.

Bone Mass and Microarchitecture in CKD Patients with Fracture

“…Strong associations were detected between fracture and parameters measured by DXA and HRpQCT (odds ratios 1.4 to 2.0), but fracture discrimination by both DXA and HR-pQCT was equivalent and AUCs were Ͻ0.75 (0.48 to 0.68). 29 Although HR-pQCT did detect microstructural differences that have been associated with fragility fractures in other studies, 19,[31][32][33][34][35] in our cross-sectional investigation, these microstructural differences did not predict fractures. Several post hoc analyses of the major registry osteoporosis clinical trials suggested that measurement of BMD by DXA may be useful to assess incident fracture risk in patients with stages 1 through 4 CKD and without biochemical evidence of CKD-MBD.…”

“…18,30,[33][34][35]46,47 Image processing and calculation of numerical values were performed using Scanco software. Briefly, the volume of interest is automatically separated into cortical and trabecular regions using a threshold-based algorithm set to one third the apparent cortical bone density.…”

Premenopausal Women with a Distal Radial Fracture Have Deteriorated Trabecular Bone Density and Morphology Compared with Controls without a Fracture

“…Previous work has shown that premenopausal women with idiopathic osteoporosis have worse trabecular architecture at the radius and tibia and thinner cortices at the distal end of the tibia than normal age-matched controls 35 . The women in our study did not have low bone mineral density, and yet they had a similar pattern of poor trabecular architecture and thinner cortices at the distal end of the tibia.…”

Challenges in longitudinal measurements with HR-pQCT: Evaluation of a 3D registration method to improve bone microarchitecture and strength measurement reproducibility

“…Bone microarchitecture parameters measured by HR-pQCT have been found to be associated with prevalent fracture in postmenopausal women and older men independently of areal bone mineral density (aBMD) [1][2][3][4][5]. Bone strength, estimated using micro-finite element analysis (μFEA), was also associated with prevalent fracture [6][7][8][9][10][11][12][13][14]. Moreover, HR-pQCT has been used to assess age-related bone loss [15][16][17][18][19] and to monitor variations in microarchitecture parameters during osteoporosis treatments [20][21][22][23][24][25][26].…”