Premenopausal Women with a Distal Radial Fracture Have Deteriorated Trabecular Bone Density and Morphology Compared with Controls without a Fracture

Evaluation of trabecular bone score in patients with a distal radius fracture

“…Although previous studies revealed that TBS has additive value for predicting vertebral and non-vertebral fractures in postmenopausal women [12][13][14][15]22], our results demonstrate that TBS is not reliable to evaluate bone frailty in patients with a DRF. This result contrasts with previous studies that reported microarchitectural deterioration of trabecular bone structure in the distal radius in pre-and postmenopausal women with a DRF, as assessed by high resolution peripheral quantitative computed tomography (HR-pQCT) [23,24]. In addition, a few studies have shown a significant correlation between TBS and skeletal microarchitecture of the distal radius in human cadavers and postmenopausal women with primary hyperparathyroidism [21,25].…”

“…It has been reported that patients with a displaced DRF have lower cortical bone density than that of patients with a nondisplaced DRF [26]. In addition, bicortical thickness of the distal radius on a radiograph and cortical thickness of the distal radius on HR-pQCT are studied as indicators of bone quality [24,27]. Furthermore, metacarpal cortical bone density, which is assessed by digital X-ray radiogrammetry, is significantly associated with a DRF in elderly women [28,29].…”

Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture

“…DXA derived aBMD at the ultradistal forearm site was also not significantly different; however, this did approach significance, with the fracture group demonstrating lower aBMD compared to the control group (Table 4). Similar to this study, Rozental et al [43] compared fracture and non-fracture groups in premenopausal women and reported no differences in aBMD at the femoral neck, lumbar spine, and distal end of the forearm, but significant differences in bone microarchitecture were observed, independent of aBMD. Although aBMD continues to be a primary bone assessment tool used in the clinical setting, aBMD alone appears insufficient to accurately predict fracture risk [44,45], especially in women younger than age 65.…”

Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families

“…(9,20) HR-pQCT was performed on the radius at the non-dominant side and on the right tibia, unless the participant had a previous adult fracture, in which case the contralateral side was scanned.…”