Bone metastasis of glandular cardiac myxoma mimicking a metastatic carcinoma

Uppin, Shantveer G; Jambhekar, Nirmala A.; Puri, Ajay; Kumar, Rajiv; Agarwal, Manish; Sanghvi, Darshana

doi:10.1007/s00256-010-0966-5

Cited by 12 publications

(5 citation statements)

References 17 publications

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“…Bone and brain metastases from glandular cardiac myxomas have been reported in the recent literature. [31][32][33][34][35][36][37][38] The most frequent metastatic site for cardiac myxomas is cerebrum. 33 Several reports have reviewed cerebral metastasis cases.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Rahman¹,

Ali²,

Kabir³

et al. 2016

Bangladesh Heart J

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Introduction: Cardiac myxoma is a benign neoplasm that represents the most common primary tumour of the heart. Because of nonspecific symptoms, early diagnosis may be a challenge. Although the left atrium is the most commonly involved site of origin in 75% of cases, it can arise from any of the cardiac chambers. Symptoms from a cardiac myxoma are more pronounced when the myxomas are left-sided, racemosus, and over 5 cm in diameter. Symptoms are produced by mechanical interference with cardiac function or embolization. Being intravascular and friable, myxomas account for most cases of tumor embolism. The site of embolism is dependent upon the location (left or right atrium) and the presence of an intracardiac shunt. Most atrial myxomas are benign and can be removed by surgical resection.Objectives: To see clinical presentation and echocardiographic profile of cardiac myoxomas.Methods: 90 cardiac myxoma patients who admitted both in cardiology and cardiac surgery departments of National Institute of Cardiovascular Diseases (NICVD), Dhaka from August 2003 to July, 2014 were studied clinically and by echocardiogram. Clinical histories were reviewed, noting age, gender, and clinical presentation.Results: There were 30 males and 60 females, ages ranged from 17 to 76 years. The commonest clinical feature was dyspnoea (94.44%), followed by palpitation (76.67%), chest discomfort (74.44%), constitutional symptoms (50%), pedal oedema (20%), syncope (14.44%), and embolization (7.7%). The mean duration of symptoms was 09.7 months.Conclusion: The clinical presentation of cardiac myxoma is often nonspecific, so high index of clinical suspicion is important for its early and correct diagnosis. The size and appearance of the myxomas correlated with the presenting symptoms.Bangladesh Heart Journal 2016; 31(1) : 18-22

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Section: Discussionmentioning

confidence: 99%

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Rahman¹,

Ali²,

Kabir³

et al. 2016

Bangladesh Heart J

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“…Skeletal sites of metastases have included the humerus, pelvis, femur, scapula, tibia, and skull. In each of these cases, biopsies proved that these bone lesions were indeed myxomas and all were ultimately excised 9‐12 . The possibility remains that the persistently thickened calvarium seen in this case may represent a metastatic myxoma.…”

Section: Discussionmentioning

confidence: 75%

Atrial Myxoma and Bone Changes: A Paraneoplastic Syndrome?

Smith

Chaudhry

Humphrey

et al. 2011

Journal of Cardiac Surgery

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Atrial myxomas are the most common benign tumors of the heart and are difficult to diagnose due to a wide variety of presenting symptoms. We present a patient with a five-year history of visual loss, vertigo, ataxia, tinnitus, and bone lesions that resolved after diagnosis and resection of an atrial myxoma. This case not only highlights an unusual presentation of atrial myxomas but also raises the question of whether atrial myxomas can produce paraneoplastic syndromes, including bone abnormalities.

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“…It may be derived from the glandular differentiation of foregut embryonic remnants or myocardial precursor cells with multi-differentiation potential [ 11 ]. The clinical features are similar to classic cardiac myxoma but may have recurrence and metastasis [ 12 , 13 ], emphasizing the necessity of a long-term follow-up observation of this patient.…”

Section: Discussionmentioning

confidence: 99%

A case report and literature review of Carney complex with atrial adenomyxoma

et al. 2023

BMC Endocr Disord

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Background Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome characterized by mucocutaneous lentigines/ blue nevi, cardiac myxoma and endocrine overactivity. Here, we report a CNC case with PRKAR1A gene mutation characterized by left atrial adenomyxoma to explore the diagnosis and treatment of CNC. Case presentation A 42-year-old woman with a history of cardiac tumour surgery presented with typical features of Cushing syndrome, including central obesity, buffalo hump, mild facial plethora, purple striae on the lower abdomen, and spotty skin pigmentation. Left atrial adenomyxoma and thyroid papillary carcinoma were identified by postoperative histologic assays. Genetic screening revealed a pathogenic germline heterozygous mutation of c.682C > T (p.R228X) in exon 7 of the PRKAR1A gene. The clinical features and normal ACTH levels suggest this patient suffered the ACTH-independent primary pigmented nodular adrenocortical disease (PPNAD) with cyclic hypercortisolism or ACTH-dependent Cushing syndrome. Conclusion CNC is uncommon, however, if a patient develops clinical features involving multiple endocrine and non-endocrine tumors, especially Cushing syndrome and cardiac myxoma, CNC should be considered. Genetic analysis is recommended in patients with suspected CNC.

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Bone metastasis of glandular cardiac myxoma mimicking a metastatic carcinoma

Cited by 12 publications

References 17 publications

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Atrial Myxoma and Bone Changes: A Paraneoplastic Syndrome?

A case report and literature review of Carney complex with atrial adenomyxoma

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Bone metastasis of glandular cardiac myxoma mimicking a metastatic carcinoma

Cited by 12 publications

References 17 publications

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Atrial Myxoma and Bone Changes: A Paraneoplastic Syndrome?

A case report and literature review of Carney complex with atrial adenomyxoma

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Clinical profile of cardiac myxoma: 11 years experience of 90 cases

Clinical profile of cardiac myxoma: 11 years experience of 90 cases