Bone metabolism markers and bone mass in healthy pubertal boys and girls

Coeverden, Silvia C.C.M. van; Netelenbos, J. C.; Ridder, C. M. De; Roos, Jan C.; Popp-Snijders, C.; Waal, Henriëtte A. Delemarre-van de

doi:10.1046/j.1365-2265.2002.01573.x

Cited by 148 publications

(129 citation statements)

References 44 publications

(51 reference statements)

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“…Our results showed that the levels of all biochemical bone markers in both patients and controls were highest in the preearly-pubertal years, followed by an overall decrease through puberty and postpubertal years, in accordance with other studies of bone markers in children, adolescents, and adults (12,(15)(16)(17)(18)(19). Previously, bone marker values have been shown to increase during early-mid puberty (Tanner breast developmental stages 2 and 3), corresponding to increasing height velocity (15,17,18).…”

Section: Rett Syndrome and Low Bone Turnoversupporting

confidence: 78%

“…Generally, bone markers are known to be related to changes in bone remodeling and in bone mass in elderly postmenopausal women (23,25) but not in young premenopausal women (28). Studies of the association between markers of bone turnover and subsequent bone gain in healthy girls have shown conflicting results (15,17,22,29). An association between bone markers and bone gain should be examined prospectively in a larger group of patients with RTT of different ages and pubertal stages.…”

Section: Rett Syndrome and Low Bone Turnovermentioning

confidence: 99%

“…Furthermore, biochemical bone markers have not been associated with measures of bone mineral density or low-energy fractures in RTT. Studies on biochemical bone markers in healthy persons have reported high levels in early childhood, peaking in puberty, and decreasing to stable levels in the mid-20s (12,(15)(16)(17)(18)(19), but the level of biochemical bone markers in children and adolescents with RTT is unknown.…”

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Low bone turnover phenotype in Rett syndrome: results of biochemical bone marker analysis

et al. 2013

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Background:Patients with Rett syndrome (RTT) are at risk of having low bone mass and low-energy fractures. Methods: We characterized bone metabolism by both bone formation and resorption markers in blood in a RTT population of 61 girls and women and 122 well-matched healthy controls. Levels of N-terminal propeptides of collagen type 1 (P1NP), C-terminal telopeptide cross links (CTX), osteocalcin (OC), and bone-specific alkaline phosphatase (B-ALP) were compared between RTT patients and controls in regression models adjusted for BMI, vitamin D status, volumetric bone mineral apparent density of the lumbar spine (vBMAD spine ), and femoral neck (vBMAD neck ). We examined biochemical bone marker levels overall and stratified to persons younger than age 25 y or equal to or older than age 25 y. results: The RTT patients had reduced levels of all biochemical bone markers (P < 0.05), which remained significant in persons younger than 25 y (P ≤ 0.001) regarding P1NP, CTX, and OC. Bone marker levels were not significantly associated to methyl-CpG-binding protein 2 (MECP2) mutation group, walking ability, or previous low-energy fractures. conclusion: Our findings of a low bone turnover state in girls with RTT suggest critical attention to medical treatment of low bone mass in young RTT patients.

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Section: Rett Syndrome and Low Bone Turnoversupporting

confidence: 78%

Section: Rett Syndrome and Low Bone Turnovermentioning

confidence: 99%

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confidence: 99%

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Low bone turnover phenotype in Rett syndrome: results of biochemical bone marker analysis

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“…(8,(22)(23)(24)(25) Although prior studies have demonstrated that biomarkers of bone metabolism were positively correlated with growth velocity, (7,24) these studies were limited to correlations between biomarkers and growth velocity without consideration of the independent effects of pubertal maturation, bone mass, and bone accrual on biomarker levels. Our data in healthy controls demonstrates that Tanner stage, sex, WB-BMC, height velocity, and WB-BMC accrual rates were all significant and independent determinants of bone biomarker levels during childhood and adolescence.…”

Section: Discussionmentioning

confidence: 99%

“…(5,6) The pubertal growth spurt is associated with dramatic elevations in biomarkers of bone metabolism paralleling growth velocity. (6,7) Biomarkers of bone metabolism in children and adolescents have traditionally been interpreted in the context of sex and age or pubertal stage. (8) However, overall skeletal mass [e.g.…”

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confidence: 99%

Interpretation of Biomarkers of Bone Metabolism in Children: Impact of Growth Velocity and Body Size in Healthy Children and Chronic Disease

Tuchman

Thayu

Shults

et al. 2008

The Journal of Pediatrics

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Objectives-To determine the effects of growth, maturation, and whole body bone mineral content (WB-BMC) accrual on biomarkers of bone formation [bone specific alkaline phosphatase (BSAP)] and resorption [urine deoxypyridinoline/creatinine (DPD)] in healthy children and children with Crohn's disease.Study design-BSAP and DPD were measured at baseline, and growth and dual energy x-ray absorptiometry (DXA) WB-BMC were measured at baseline and six months in 202 controls and 110 subjects with Crohn's disease, ages 5 to 21 years. Multivariable linear regression identified determinants of biomarkers in controls and subjects with Crohn's disease.Results-In controls, BSAP and DPD were significantly and independently associated with sex, Tanner stage, WB-BMC, height velocity, and WB-BMC accrual rates; these covariates explained 77-80% of the variability in bone biomarkers. Subjects with Crohn's disease had lower height-forage (p < 0.001) and WB-BMC-for-height (p < 0.05), compared with controls. Crohn's disease was associated with lower BSAP (p < 0.001) and greater DPD (p < 0.001), independent of growth, maturation, baseline WB-BMC, and WB-BMC accrual, compared with controls.Conclusions-These data illustrate the potential confounding effects of growth and WB-BMC on bone metabolism biomarkers in children. After adjustment for these effects, Crohn's disease was associated with lower biomarkers of bone formation and greater bone resorption. KeywordsCrohn's disease; height velocity; bone-specific alkaline phosphatase; urine deoxypyridinoline; dual energy x-ray absorptiometry; bone mineral content Corresponding/Reprint request author: Shamir Tuchman MD, MPH, Division of Pediatric Nephrology, Department of Pediatrics, The Children' s Hospital of Philadelphia, 34 th and Civic Center Blvd., Philadelphia, PA 19104, pH: (215) 590-2449, fax: (215) 590-3705, email: E-mail: tuchman@email.chop.edu. Edited by TW and WFB Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.The authors declare no conflicts of interest. Serum levels of biomarkers of bone formation were significantly reduced in children with newly diagnosed Crohn's disease, and biomarkers of bone resorption were variably reduced in comparison with controls; thus, bone remodeling may be suppressed in incident Crohn's disease due to a primary impairment in bone formation. (9) The accompanying editorial suggested that these findings support the use of anabolic agents as opposed to anti-resorptive agents in childhood Crohn's disease.(10) However, low overall bone mass (i.e. reduced numbers of osteoblasts and osteoclasts) and reduced ...

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Fetal and Childhood Growth Patterns Associated with Bone Mass in School-Age Children: The Generation R Study

Heppe

Medina‐Gomez

Jongste

et al. 2014

Journal of Bone and Mineral Research

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Low birth weight is associated with lower bone accrual in children and peak bone mass in adults. We assessed how different patterns of longitudinal fetal and early childhood growth influence bone properties at school age. In 5431 children participating in a population-based prospective cohort study, we measured fetal growth by ultrasound at 20 and 30 weeks gestation, and childhood growth at birth, 1, 2, 3, and 4 years of age. We analyzed these growth measurements in relation to total body (less head) BMD measured by DXA at age 6. We used conditional growth modeling; a technique which takes into account correlation between repeatedly measured growth measures. Our results showed that estimated fetal weight gain, femur length growth between 20 and 30 weeks of gestation, femur length growth between 30 weeks and birth, as well as all height and weight growth measurements from birth to 4 years of age were all positively associated with BMC, bone area (BA), and BMD (all p < 0.01). Fetal femur length growth between 30 weeks and birth was positively associated with BMC and BA (both p < 0.001), but not with BMD. Overall, childhood growth measurements exerted a larger influence on bone measures than fetal growth measures. The strongest effect estimate was observed during the first year of life. Children born small (<10th percentile) for gestational age (SGA) had lower BMC and BA, but not BMD, than children born appropriate for gestational age (AGA), whereas children born large (>90th percentile) for gestational age (LGA) had higher BMC and BA (all p < 0.001). These differences were no longer present in children showing subsequent accelerated and decelerated infant growth, respectively. We conclude that both fetal and childhood growth patterns are associated with bone mineral accrual, showing the strongest effect estimates in infancy. Compensatory infant growth counteracts the adverse consequences of fetal growth restriction on bone development.

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Bone metabolism markers and bone mass in healthy pubertal boys and girls

Cited by 148 publications

References 44 publications

Low bone turnover phenotype in Rett syndrome: results of biochemical bone marker analysis

Low bone turnover phenotype in Rett syndrome: results of biochemical bone marker analysis

Interpretation of Biomarkers of Bone Metabolism in Children: Impact of Growth Velocity and Body Size in Healthy Children and Chronic Disease

Fetal and Childhood Growth Patterns Associated with Bone Mass in School-Age Children: The Generation R Study

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