Bone metabolism and risk of secondary hyperparathyroidism 12 months after gastric banding in obese pre-menopausal women

Pugnale, Nathalie; Giusti, Vittorio; Suter, Michel; Zysset, E.; Héraïef, E; Gaillard, R. C.; Burckhardt, P.

doi:10.1038/sj.ijo.0802177

Cited by 110 publications

(84 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since patients with primary or secondary hyperparathyroidism were heavier than those in the control group, it has been postulated that increased PTH levels contribute towards obesity (6,47,48). Conversely, PTH decreased after weight loss in our study in concordance with most studies in obese adults (19,20,49), suggesting that the elevated serum PTH is a result and not a cause of obesity. Furthermore, we observed no alteration of 1,25-OH Vit D levels in our study of obese children.…”

Section: Discussionsupporting

confidence: 82%

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Reinehr¹,

Sousa²,

Alexy³

et al. 2007

eur j endocrinol

181

114

View full text Add to dashboard Cite

Objective: The roles of vitamin D and parathyroid hormone (PTH) are discussed controversially in obesity, and studies of these hormones in obese children are limited. Therefore, we studied the relationships between PTH, 1,25-dihydroxy-vitamin D (1,25-OH Vit D), 25-hydroxy-vitamin D (25-OH Vit D), weight status, and insulin sensitivity before and after weight loss in obese children. Methods: Fasting serum PTH, 1,25-OH Vit D, 25-OH Vit D, inorganic phosphate, calcium, alkaline phosphatase (AP), insulin, glucose, and weight status (SDS-BMI and percentage body fat) were determined in 133 obese children (median age 12.1 years) and compared with 23 non-obese children. Furthermore, these parameters were analyzed in 67 obese children before and after participating in a 1-year obesity intervention program. Results: Obese children had significantly (P!0.001) higher PTH and lower 25-OH Vit D concentrations compared with non-obese children, while calcium, phosphate, AP, and 1,25-OH Vit D did not differ significantly. Changes of PTH (rZ0.23, PZ0.031) and 25-OH Vit D (rZK0.27, PZ0.013) correlated significantly with changes of SDS-BMI, but not with changes of insulin sensitivity (homeostasis model assessment; HOMA-B%). Reduction of overweight in 35 children led to a significant (P!0.01) decrease of PTH concentrations and an increase in 25-OH Vit D levels. Conclusions: PTH levels were positively and 25-OH Vit D concentrations were negatively related to weight status. Since these alterations normalized after weight loss, these changes are consequences rather than causes of overweight. A relationship between PTH, vitamin D, and insulin sensitivity based on the HOMA index was not found in obese children. Further longitudinal clamp studies are neccessary to study the relationship between vitamin D and insulin sensitivity. European Journal of Endocrinology 157 225-232Introduction Vitamin D and parathyroid hormone (PTH) are well known for their essential role in bone metabolism and calcium homeostasis. The main sources of vitamin D are ergocalciferol and cholecalciferol, the former normally available in food and the latter produced in the skin by u.v. radiation of 7-dehydrocholesterol. Both of these compounds are hydroxylated in the liver to 25-hydroxyvitamin D (25-OH Vit D), which is the major circulating metabolite precursor to the hormonally active form, 1,25-dihydroxy-vitamin D (1,25-OH Vit D).It has become increasingly clear that the vitamin D endocrine system is related to obesity in adults. Obesity has been found to be associated with lower levels of serum 25-OH Vit D (1-5) and higher levels of serum PTH (1,(5)(6)(7)(8). A low vitamin D intake was associated with increased body mass index (BMI) (9). PTH has been postulated as an independent predictor of obesity (7). Overweight as a consequence of elevated serum PTH was explained by several mechanisms (10, 11): PTH stimulates the renal hydroxylation of 25-OH Vit D to its active form, 1,25-OH Vit D, which in turn elevates the calcium influx into adipocytes. In these cell...

show abstract

Section: Discussionsupporting

confidence: 82%

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Reinehr¹,

Sousa²,

Alexy³

et al. 2007

eur j endocrinol

181

114

View full text Add to dashboard Cite

show abstract

“…The increased excretion of calcium is in parallel with sodium excretion (29), and the elevation of the latter may be a result of a higher salt intake in obese subjects (30). Furthermore, serum PTH decreases with weight loss in obese subjects both on a low-calorie diet (28) and after laparoscopic gastric banding (31).…”

Section: Discussionmentioning

confidence: 99%

Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study

Kamycheva

Sundsfjord

Jorde

2004

European Journal of Endocrinology

173

103

View full text Add to dashboard Cite

Objective: To study whether serum parathyroid hormone (PTH) and serum calcium are associated with body mass index (BMI), and their predicting role in obesity. Design: Population based, cross-sectional study. Methods:In 2001 a population-based health survey was held in Tromsø, North Norway. Questionnaires on medical history and life-style factors were completed and anthropometric data were collected. Calcium and vitamin D intakes and a physical activity score were calculated. Serum calcium and PTH were measured in a subset of 3447 men and 4507 women. Pearson correlation and linear regression were used to evaluate associations between BMI, PTH and serum calcium, and logistic regression was used to test PTH and serum calcium as predictors of obesity and to calculate odds ratio. Relative risk was calculated using frequency tables. Results: For serum calcium and PTH there was a significant positive relation to BMI in both genders (P , 0.001), which to our knowledge has not previously been reported on the basis of a large epidemiological study. Age, low calcium and vitamin D intakes were explanatory variables for serum PTH. The highest quartile of serum PTH (.4.20 pmol/l) was a significant predictor for obesity (P , 0.001) in both genders, adjusted for age, physical activity and serum calcium. Obesity rates were higher in those with PTH levels in the highest quartile compared with those in the lower quartiles, which resulted in a relative risk of 1.40 (95% confidence interval (C.I.) 1.20 -1.60) for men and 1.48 (95% C.I. 1.31 -1.67) for women. Conclusions: Serum PTH, adjusted for age, physical activity and serum calcium, is positively associated with BMI in both sexes, and serum PTH is an independent predictor of obesity in our statistical model.

show abstract

“…2 Studies show that serum PTH levels are higher in obese than in nonobese young adults 3,4 and decline with weight loss. [5][6][7] In addition, hyperparathyroid postmenopausal women have a greater fat mass with a more android pattern of fat distribution compared to age-matched controls. 8 Serum PTH has also been proposed to mediate the putative effect of dietary calcium on changes in body composition.…”

Section: Introductionmentioning

confidence: 99%

Parathyroid hormone is associated with decreased fat mass in young healthy women

et al. 2005

View full text Add to dashboard Cite

Objective: To investigate the relationship of parathyroid hormone (PTH) with dietary calcium and changes in body composition. Design: Cross-sectional and 1-year longitudinal trial. Subjects: Normal-weight young women (age: 18-31), 155 subjects analyzed at baseline, and data for 41 subjects analyzed prospectively between baseline and 12 months. Measurements: Levels of fasting serum calcium and PTH, intakes of calcium (3-day diet records), and total body weight and body composition (dual energy X-ray absorptiometry). Results: Baseline dietary calcium, regardless of whether unadjusted or adjusted for energy intake, did not predict baseline levels of fasting serum PTH. Change in dietary calcium also did not predict change in serum PTH. However, log PTH was significantly correlated with body fat mass (R ¼ 0.27), but not lean mass at baseline (n ¼ 155), independent of serum calcium (corrected R ¼ 0.25). Further, 12-month changes (n ¼ 41) in log PTH positively predicted the 12-month change in body weight (R ¼ 0.32) and body fat (R ¼ 0.32), but not lean mass even when controlled for age or change in serum calcium. Conclusion: Fasting serum PTH was associated with increased fat mass, in both cross-sectional and prospective analysis. Thus, serum PTH may play a role in the regulation of body fat mass in young women.

show abstract

Bone metabolism and risk of secondary hyperparathyroidism 12 months after gastric banding in obese pre-menopausal women

Cited by 110 publications

References 45 publications

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study

Parathyroid hormone is associated with decreased fat mass in young healthy women

Contact Info

Product

Resources

About