Bone matrix glycosaminoglycans and osteoporosis development in early aging OXYS rats

Ershov, Konstantin; Русова, Т. В.; Falameeva, O. V.; Sadovoy, M. A.; Айзман, Р. И.; Kolosova, N. G.

doi:10.1134/s2079057011010061

Cited by 2 publications

(4 citation statements)

References 17 publications

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“…Chitosan’s unique properties have led to its exploration as a potential carrier for drugs as well as for structural implants to enhance bone healing. Structurally akin to glycosaminoglycan (itself a vital component in collagen formation and bone matrix development), chitosan offers unique advantages in bone tissue applications [ 12 , 13 ]. It has demonstrated osteoinductive properties, attracting bone components like hydroxyapatite and initiating bone regeneration [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Historically, bone grafts involve harvesting bone tissue either from the patient or a donor (autografts or allografts) for transplantation. Materials like chitosan make ideal substances for synthetic bone grafts [ 12 , 13 , 15 ]. It would act as a scaffold and provide structural support for bone tissue and reduce the need for pre-surgery scrapings.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Potential of Chitosan Nanoparticles as a Delivery Vehicle for Gentamicin for the Treatment of Osteomyelitis

Simpson,

Sarwar,

Jack

et al. 2024

Antibiotics

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Chitosan nanoparticle delivery systems have the potential for enhancing bone healing and addressing osteomyelitis. The objective was to deliver antimicrobial agents capable of preventing or treating osteomyelitis. Each formulation was optimized to achieve desired characteristics in terms of size (ranging from 100 to 400 nm), PDI (less than 0.5), zeta potential (typically negative), and in vitro release profiles for gentamicin. Entrapment percentages varied with gentamicin ranging from 10% to 65%. The chitosan nanoparticles exhibited substantial antimicrobial efficacy, particularly against P. aeruginosa and MRSA, with zones of inhibition ranging from 13 to 24 mm and a complete reduction in colony forming units observed between 3 and 24 h. These chitosan nanoparticle formulations loaded with antimicrobials hold promise for addressing orthopedic complications.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Potential of Chitosan Nanoparticles as a Delivery Vehicle for Gentamicin for the Treatment of Osteomyelitis

Simpson,

Sarwar,

Jack

et al. 2024

Antibiotics

View full text Add to dashboard Cite

show abstract

“…Chitosan's unique properties have led to its exploration as a potential carrier for drugs and structural implants to enhance bone healing. Structurally akin to glycosaminoglycan, a vital component in collagen formation and bone matrix development, chitosan offers unique advantages in bone tissue applications [12,13]. It has demonstrated osteoinductive properties, attracting bone components like hydroxyapatite and initiating bone regeneration [14].…”

Section: Introductionmentioning

confidence: 99%

“…Historically, bone grafts involved harvesting bone tissue either from the patient or a donor (autografts or allografts) for transplantation. Materials like chitosan, owing to their structural resemblance to glycosaminoglycan, porosity facilitating nutrient transport, and vascularization, make them ideal candidates for synthetic bone grafts [12,13,15]. These scaffolds offer structural support for bone tissue and reduce the need for pre-surgery scrapings, lowering the risk of complications such as infection.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Potential of Chitosan Nanoparticles as a Delivery Vehicle for Gentamicin for the treatment of Osteomyelitis

Simpson,

Sarwar,

Lowry

2023

Preprint

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Chitosan nanoparticle delivery systems have potential for enhancing bone healing and addressing osteomyelitis. The objective was to deliver antimicrobial agents capable of preventing or treating osteomyelitis. Each formulation was optimized to achieve desired characteristics in terms of size (ranging from 100 to 400 nm), PDI (less than 0.5), zeta potential (typically negative), and in vitro release profiles for gentamicin. Entrapment percentages varied with gentamicin ranging from 10% to 65%. The chitosan nanoparticles exhibited substantial antimicrobial efficacy, particularly against both P. aeruginosa and MRSA, with zones of inhibition ranging from 13 to 24 mm and complete reduction in colony forming units observed between 3 to 24 hours. These chitosan nanoparticle formulations loaded with antimicrobials hold promise for addressing orthopedic complications.

show abstract

Bone matrix glycosaminoglycans and osteoporosis development in early aging OXYS rats

Cited by 2 publications

References 17 publications

Evaluation of the Potential of Chitosan Nanoparticles as a Delivery Vehicle for Gentamicin for the Treatment of Osteomyelitis

Evaluation of the Potential of Chitosan Nanoparticles as a Delivery Vehicle for Gentamicin for the Treatment of Osteomyelitis

Evaluation of the Potential of Chitosan Nanoparticles as a Delivery Vehicle for Gentamicin for the treatment of Osteomyelitis

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