Evaluation of the Potential of Chitosan Nanoparticles as a Delivery Vehicle for Gentamicin for the treatment of Osteomyelitis
Elliot Simpson,
Humera Sarwar,
Deborah Lowry
Abstract:Chitosan nanoparticle delivery systems have potential for enhancing bone healing and addressing osteomyelitis. The objective was to deliver antimicrobial agents capable of preventing or treating osteomyelitis. Each formulation was optimized to achieve desired characteristics in terms of size (ranging from 100 to 400 nm), PDI (less than 0.5), zeta potential (typically negative), and in vitro release profiles for gentamicin. Entrapment percentages varied with gentamicin ranging from 10% to 65%. The chitosan nano… Show more
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