Bone mass and vitamin D levels in women with a diagnosis of fibromyalgia

Mateos, Félix P. Arce; Valero, Carmen; Olmos, José M.; Casanueva, Benigno; Castillo, J.; Martínez, Josefina; Hernández, José L.; Macías, J. González

doi:10.1007/s00198-013-2434-2

Cited by 30 publications

(29 citation statements)

References 34 publications

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“…Reviewing the titles and abstracts revealed 644 irrelevant papers. Investigating the full texts of the remaining articles [ 1 3 5 14 16 22 23 24 25 26 27 28 29 ], two irrelevant papers [ 22 27 ] were also excluded. Others were quality assessed and entered into the final meta-analysis ( Fig.…”

Section: Resultsmentioning

confidence: 99%

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Vitamin D and fibromyalgia: a meta-analysis

et al. 2017

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Vitamin D is a cofactor responsible for autoimmune disorders. There is no agreement in the studies investigating the association between vitamin D and fibromyalgia. This study aims to combine the conflicting results of the primary studies which compared these patients with control groups regarding the serum concentration of vitamin D. This meta-analysis has been designed based on PRISMA guidelines. Relevant keywords were searched in PubMed, Science direct, Scopus, Cochrane, and Google scholar and primary studies were selected. After screening the eligible studies according to inclusion/exclusion criteria, we investigated the risk of bias in the selected studies and also the heterogeneity between the primary results using Cochrane (Q) and I-squared (I2) indices. The primary results were combined using inverse variance method and Cohen statistics as well as a random effects model. Publication bias was assessed using Egger test. Sensitivity analysis was applied to investigate the influence of each primary study on the final result of the meta-analysis. Suspected factors in the heterogeneity were assessed using meta-regression models. We entered 12 eligible studies in the meta-analysis including 851 cases compared with 862 controls. The standardized mean difference of Vitamin D between the two groups was −0.56 (95% confidence interval: −1.05, −0.08). Our meta-analysis showed that vitamin D serum levels of patients with fibromyalgia was significantly lower than that of control group.

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Section: Resultsmentioning

confidence: 99%

“…The largest sample size (205 cases and controls) was used in the study conducted by Mateos et al [ 25 ] while the Baygutalp study [ 5 ] with 19 cases/controls included the smallest sample size. Both of these studies reported lower blood vitamin D levels in FM patients than in controls.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and fibromyalgia: a meta-analysis

et al. 2017

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“…A recent study also assessed BMD in 205 patients with FM and 205 healthy controls using dual absoptiometry. No differences in BMD were evident between the two groups [ 54 ].…”

Section: Fibromyalgia and Vitamin Dmentioning

confidence: 99%

Vitamin D in Fibromyalgia: A Causative or Confounding Biological Interplay?

et al. 2016

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Fibromyalgia (FM) is a chronic syndrome with an increasing prevalence, characterized by widespread musculoskeletal pain in combination with a variety of cognitive symptoms and fatigue. A plethora of scientific evidence that has accumulated during the last decades, resulted in a significant improvement of the understanding of the pathophysiology of the disease. However, current therapeutic approaches in patients with FM remains a multidimensional approach including patient education, behavioral therapy, exercise, pain management, and relief of chronic symptoms, rather than the use drug therapies, based on the mechanisms of disease development. Vitamin D, a fat-soluble vitamin derived mainly from skin synthesis through ultraviolet radiation, has been recognized to manifest a plethora of extraskeletal actions, apart from its fundamental role in skeletal and calcium homeostasis, including modulation of cell growth, neuromuscular actions, and potential anti-inflammatory properties. Recent findings indicate that hypovitaminosis D to be highly prevalent in patients with FM. Supplementation studies are limited so far, indicating potential beneficial effects on pain and severity of the disease, however specific recommendations are lacking. This review aims to summarize and critically appraise data regarding the pathophysiological interplay between vitamin D and FM, available results from observational and supplementation studies so far, with a clinical discourse on current knowledge gaps and future research agenda.

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“…In recent years, numerous studies were designed to clear an association between a low level of calciferol and FM, two conditions that were prevalent and also lead to chronic pain. In spite of many efforts, the evidence for an association between them is unconvincing; with no progression in pain when on a vitamin D supplement [ 2 3 4 5 6 7 8 24 ]. Many reports have showed that vitamin D deficiency can be implicated in nonspecific chronic pain or FM, and some trials have advocated a vitamin D supplement for treatment of FM [ 6 7 8 25 ], but others have not confirmed it [ 2 3 4 5 25 26 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Vitamin D Status in Iranian Fibromyalgia Patients: according to the Symptom Severity and Illness Invalidation

Maafi¹,

Ghavidel‐Parsa²,

Haghdoost³

et al. 2016

Korean J Pain

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BackgroundThis study was designed to assess serum vitamin D status (25-OHD) in the fibromyalgia (FM) patients and to compare it with a healthy control group. It also aimed to investigate the correlation of serum vitamin D level with FM symptom severity and invalidation experiences.MethodsA total of 74 consecutive patients with FM and 68 healthy control participants were enrolled. The eligible FM patients completed the Illness Invalidation Inventory (3*I), the Revised Fibromyalgia Impact Questionnaire (FIQR) and a short-form health survey (SF-12). Venous blood samples were drawn from all participants to evaluate serum 25-OHD levels. Mann-Whitney tests and multiple logistic regression analyses were performed and Spearman's correlations were calculated.Results88.4% of FM patients had low levels of serum 25-OHD. FM patients had significantly higher level of serum 25-OHD than the control group (17.24 ± 13.50 and 9.91 ± 6.47 respectively, P = 0.0001). There were no significant correlations between serum 25-OHD levels and the clinical measures of disease impact, invalidation dimensions, and health status. Multiple logistic regression analyses revealed that an increased discounting of the disease by the patient's spouse was associated with a 4-fold increased risk for vitamin D deficiency (OR = 4.36; 95% CI, 0.95–19.87, P = 0.05).ConclusionsThis study showed that although high rates of vitamin D insufficiency or deficiency were seen among FM patients and healthy non-FM participants, but it seems there was no intrinsic association between FM and vitamin D deficiency. Addressing of invalidation experience especially by the patient's spouse is important in management of FM.

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Bone mass and vitamin D levels in women with a diagnosis of fibromyalgia

Cited by 30 publications

References 34 publications

Vitamin D and fibromyalgia: a meta-analysis

Vitamin D and fibromyalgia: a meta-analysis

Vitamin D in Fibromyalgia: A Causative or Confounding Biological Interplay?

Serum Vitamin D Status in Iranian Fibromyalgia Patients: according to the Symptom Severity and Illness Invalidation

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