Vitamin D and fibromyalgia: a meta-analysis

Abstract

Vitamin D is a cofactor responsible for autoimmune disorders. There is no agreement in the studies investigating the association between vitamin D and fibromyalgia. This study aims to combine the conflicting results of the primary studies which compared these patients with control groups regarding the serum concentration of vitamin D. This meta-analysis has been designed based on PRISMA guidelines. Relevant keywords were searched in PubMed, Science direct, Scopus, Cochrane, and Google scholar and primary studies were selected. After screening the eligible studies according to inclusion/exclusion criteria, we investigated the risk of bias in the selected studies and also the heterogeneity between the primary results using Cochrane (Q) and I-squared (I2) indices. The primary results were combined using inverse variance method and Cohen statistics as well as a random effects model. Publication bias was assessed using Egger test. Sensitivity analysis was applied to investigate the influence of each primary study on the final result of the meta-analysis. Suspected factors in the heterogeneity were assessed using meta-regression models. We entered 12 eligible studies in the meta-analysis including 851 cases compared with 862 controls. The standardized mean difference of Vitamin D between the two groups was −0.56 (95% confidence interval: −1.05, −0.08). Our meta-analysis showed that vitamin D serum levels of patients with fibromyalgia was significantly lower than that of control group.

Comparison between Acupuncture and Nutraceutical Treatment with Migratens® in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial

“…The nutritional preparation was selected from the current literature (Pubmed, Uptodate, and Google Scholar) using the keywords fibromyalgia and nutraceutical treatment. The literature reported efficacy evidence in FMS for coenzyme Q10, vitamin D, alpha-lipoic acid, magnesium, and tryptophan [7,[12][13][14][15]. Considering the nutraceutical composition and properties, the best therapeutic option was found to be a nutritional product containing all the substances considered above (Migratens ® , Laborest srl, Assago, Milano, Italy).…”

“…In FMS patients, the role of vitamin D deficits and supplementation is controversial. In some systematic reviews, a correlation between vitamin D deficiency and fibromyalgia was determined, whereas its role in the pathophysiology and its clinical relevance requires further controlled studies [12,49]. More recent reviews reported as inconclusive the relationship between hypovitaminosis D and FMS, although vitamin D supplementation was considered as a co-adjuvant in FMS therapy [50].…”

Intestinal dysbiosis and hormonal neuroendocrine secretion in the fibromyalgic patient

“…Based on what was discussed above, therefore, a lower level of cortisol in the circulation could be connected with a condition of dysbiosis in which there is an increase in the genus of Ruminococcus: both situations have been described in the patient with FM. • Vitamin D. In the patient with FM, a lower concentration of vitamin D3 was noted [33][34][35] and it appears to lead to an increase in chronic pain, one of the most serious symptoms of the disease. Vitamin D is able to reduce pain by releasing cytokines 36 or reducing the sensitivity of nerve fibers in the muscles 37,38 .…”

Fibromiyalji Sendromunda D Vitamin Düzeylerinin Değerlendirilmesi

“…Literatürde FMS ile vitamin D düzeyi ve vitamin D düzeyinin kliniğe etkisini inceleyen çalışmalar olmakla birlikte, FMS ve vitamin D düzeyi arasındaki ilişki konusunda tam bir fikir birliği yoktur (8,9,(14)(15)(16)(17)…”