Bone mass and exercise

Chestnut, Charles

doi:10.1016/0002-9343(93)90379-4

Cited by 54 publications

(18 citation statements)

References 12 publications

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“…19 20 Bones in women with recent onset disease, however, will probably benefit less from exercise than those in patients with prolonged disease duration and more reduced bone mass. 47 In a recent study, a 12 month weightbearing exercise programme tended to reduce bone loss from the femoral neck and spine in steroid treated women with RA, but statistical significance was not reached. 48 Thus the effect of exercise on BMD in RA may be small in the short term, but it might be substantial if accumulated over a number of years through continuing exercise programmes.…”

Section: Discussionmentioning

confidence: 94%

Bone quality and bone mass as assessed by quantitative ultrasound and dual energy x ray absorptiometry in women with rheumatoid arthritis: relationship with quadriceps strength

Madsen

Sørensen²,

Egsmose³

2002

Annals of the Rheumatic Diseases

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Section: Discussionmentioning

confidence: 94%

Bone quality and bone mass as assessed by quantitative ultrasound and dual energy x ray absorptiometry in women with rheumatoid arthritis: relationship with quadriceps strength

Madsen

Sørensen²,

Egsmose³

2002

Annals of the Rheumatic Diseases

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“…or disuse from illness. People with low bone mass are more prone to skeletal fragility when they undergo sedentary changes in lifestyle (no exercise) or when they experience disuse due either to illness or surgery (Waugh et al 2009;Joakimsen et al 1998;Chesnut 1993). It seems that people with high bone mass (Little et al 2002) may experience relatively lesser risk to skeletal fragility due to disuse when compared to people with lower bone mass.…”

Section: Discussionmentioning

confidence: 94%

Disuse-related decline in trabecular bone structure

Akhter

Alvarez

Cullen

et al. 2010

Biomech Model Mechanobiol

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Sedentary life style may degrade bone mass and microstructure resulting in osteoporosis. We characterized trabecular bone structural properties to determine if the LRP5 G171V mutation will protect against disuse-related bone loss. Forty-eight adult male mice representing three genotypes (WT = wild type, KO = LRP5-knockout +/-, HBM = High bone with the LRP5 G171V mutation) were each randomly divided between control and disuse (4 week hindlimb suspension) groups. Trabecular bone volume fraction (BV/TV) declined in all the three genotypes. Trabecular thickness was lower in the HBM and LRP5 (+/-) KO disuse groups when compared to their respective controls. While the remaining measures of bone structure (Trabecular number, connectivity density, apparent and tissue density) were lower, the trabecular separation increased in the LRP5 (+/-) with disuse. Although the absolute loss in BV/TV was similar, the relative loss due to disuse was far greater in the LRP5 (+/-) mice (67%) than in the HBM mice (14%). The disuse caused 20% decrease in trabecular number and thickness for LRP5 (+/-), while the decline was between 6 and 11% for the HBM and WT mice.

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“…Trabecular bone in the epiphysis is less stiff than cortical bone in the diaphysis,69 70 and Young’s modulus in the lateral direction is smaller than that in the axial direction 71. Lateral loads to the distal femoral epiphysis can therefore be more effective than axial loads to any other site in mobilising the flow of interstitial fluid from the epiphysis towards the metaphysis and the diaphysis.…”

Section: Potential Mechanismsmentioning

confidence: 99%

Joint Loading Modality: Its Application to Bone Formation and Fracture Healing

2007

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Sports related injuries such as impact and stress fractures often require a rehabilitation program to stimulate bone formation and accelerate fracture healing. This review introduces a recently developed joint loading modality and evaluates its potential applications to bone formation and fracture healing in post-injury rehabilitation. Bone is a dynamic tissue whose structure is constantly altered in response to its mechanical environments. Indeed, many loading modalities can influence the bone remodeling process. The joint loading modality is, however, able to enhance anabolic responses and accelerate wound healing without inducing significant in situ strain at the site of bone formation or fracture healing. This review highlights the unique features of this loading modality and discusses its potential underlying mechanisms as well as possible clinical applications.

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Bone mass and exercise

Cited by 54 publications

References 12 publications

Bone quality and bone mass as assessed by quantitative ultrasound and dual energy x ray absorptiometry in women with rheumatoid arthritis: relationship with quadriceps strength

Bone quality and bone mass as assessed by quantitative ultrasound and dual energy x ray absorptiometry in women with rheumatoid arthritis: relationship with quadriceps strength

Disuse-related decline in trabecular bone structure

Joint Loading Modality: Its Application to Bone Formation and Fracture Healing

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