Bone mass and dietary intake in children and adolescents with type 1 diabetes mellitus

Leão, Andreia Araújo Porchat; Fritz, Camilla Kapp; Dias, Marcia Regina Messaggi Gomes; Carvalho, Julienne Ângela Ramires de; Mascarenhas, Luís Paulo Gomes; Cat, Mônica Nunes Lima; Radominski, Rosana Bento; Nesi-França, Suzana

doi:10.1016/j.jdiacomp.2020.107573

Cited by 9 publications

(10 citation statements)

References 27 publications

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“…To save the influence of changes in BMD induced by sex hormones, we selected a fairly homogeneous initial group, with 70% of cases in Tanner stage I. Like most authors, we have not found any relationship between bone mineral density and the degree of metabolic control or the time of evolution of the disease 4,13,14,15 . In our case, none of our diabetics had good metabolic control, which prevented us from making a comparison in this regard.…”

Section: Discussionmentioning

confidence: 83%

“…However, in the pediatric population with DM1, longitudinal studies are very limited and with discrepant results. Some authors report a reduction in BMD during follow-up 6,12,13 , while others do not observe long-term changes 14,15 . These discrepant results may be due to multiple variables such as the length of followup, which is almost always too short; the different ages and anthropometric variables, or the different pubertal stages of the diabetic population included in the studies [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Cambios en la masa ósea en una población infantil con diabetes mellitus tipo 1. Estudio longitudinal

Gámez

Nuñez

Vega

et al. 2022

Rev Osteoporos Metab Miner

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Objetive: To evaluate, over a 79.2-month follow-up period, the behavior of bone mineral density (BMD) determined by Computerized Axial Densitometry (DXA), volumetric bone mineral density (BMDvol) and its relationship with anthropometric data, together with the parameters related to bone metabolism (calcium, phosphorus, alkaline phosphatase, parathormone (PTH) and vitamin D (25-OH-D3)) in a child population with Type 1 Diabetes Mellitus (DM1) without microvascular complications and a control group of reference with similar characteristics. Material and methods: Initially, a cross-sectional study was carried out in 40 diabetic children (mean age 9.4±2.8 years) and 108 controls (9.3±1.5 years) to assess the possible differences between the two populations. 26 patients from the initial diabetic group were reassessed after 79.2 months of follow-up. Results: It was observed that, at baseline, bone mass was similar in diabetics and controls. After follow-up, the BMD of the diabetic children was much lower than that expected in the non-diabetic child population. Weight, height, and Body Mass Index (BMI) followed the same pattern as BMD. The values of calcium, phosphorus, alkaline phosphatase, PTH and vitamin D, although within the normal range, were lower than in the controls. Alkaline phosphatase did not increase in the pubertal period. Conclusions: The present study demonstrates that children and adolescents with a recent diagnosis of DM1 have a normal BMD. However, over time, and especially during adolescence, they show less bone mass gain and changes in bone turnover parameters.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 98%

Cambios en la masa ósea en una población infantil con diabetes mellitus tipo 1. Estudio longitudinal

Gámez

Nuñez

Vega

et al. 2022

Rev Osteoporos Metab Miner

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“…This prevalence was similar to that observed among participants with T1D in the SEARCH study, where 37% (aged <15 years) and 45% (aged >15 years) were below the RDA for calcium ( 16 ). Smaller studies conducted outside the United States have reported even higher rates of calcium deficiency ( 13 , 17 ). The sex- and age-related differences in calcium intake in our study mirrored those reported in a representative sample of US children ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

“…Optimization of calcium intake is a fundamental tenet of childhood bone health, based upon strong evidence that calcium sufficiency promotes bone mineral accrual and supports the attainment of peak bone mass (12). The positive association between calcium intake and bone mass has also been recently demonstrated in children with T1D (13). Despite the known adverse effects of T1D on bone density and quality (14), few studies have investigated calcium intake in the T1D population.…”

Section: Discussionmentioning

confidence: 99%

Female Sex and Obesity Are Risk Factors for Inadequate Calcium Intake in Youth With Type 1 Diabetes

Rahmani¹,

Stevens²,

Rackovsky³

et al. 2021

Front. Clin. Diabetes Healthc.

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People with type 1 diabetes (T1D) are at increased risk of developing low bone mineral density and fractures. Optimization of calcium intake is a key component of pediatric bone health care. Despite the known risk factors for impaired bone health in T1D and the known benefits of calcium on bone accrual, there are limited data describing calcium intake in youth with T1D. In this cross-sectional study, calcium intake was assessed in 238 youth with T1D. One third of study participants were found to have inadequate calcium intake. Female sex, especially during adolescence, and obesity were identified as specific risk factors for inadequate calcium intake. Given the known adverse effects of T1D on bone health, efforts to promote calcium intake in youth with T1D should be considered.

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“…Specifically, a recent cross-sectional study by Weber found that one third of youth with T1D studied had inadequate calcium intake [ 85 ]. Another study from Brazil reported low dietary calcium intake in 76% of children with T1D and optimal serum vitamin D levels in only 18% of children with T1D [ 86 ]. In that same study, calcium intake was correlated with bone mass.…”

Section: Introductionmentioning

confidence: 99%

Diabetic Bone Disease and Diabetic Myopathy: Manifestations of the Impaired Muscle-Bone Unit in Type 1 Diabetes

Travis

Srivastava

Hawke

et al. 2022

Journal of Diabetes Research

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Type 1 diabetes is associated with complications affecting muscle and bone, with diabetic bone disease and diabetic myopathy becoming increasingly reported in the past few decades. This review is aimed at succinctly reviewing the literature on the current knowledge regarding these increasingly identified and possibly interconnected complications on the musculoskeletal system. Furthermore, this review summarizes several nonmechanical factors that could be mediating the development and progression of premature musculoskeletal decline in this population and discusses preventative measures to reduce the burden of diabetes on the musculoskeletal system.

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Bone mass and dietary intake in children and adolescents with type 1 diabetes mellitus

Cited by 9 publications

References 27 publications

Cambios en la masa ósea en una población infantil con diabetes mellitus tipo 1. Estudio longitudinal

Cambios en la masa ósea en una población infantil con diabetes mellitus tipo 1. Estudio longitudinal

Female Sex and Obesity Are Risk Factors for Inadequate Calcium Intake in Youth With Type 1 Diabetes

Diabetic Bone Disease and Diabetic Myopathy: Manifestations of the Impaired Muscle-Bone Unit in Type 1 Diabetes

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