Bone marrow toxicity in vitro of chloramphenicol and its metabolites

Gross, Brion J.; Branchflower, Richard V.; Burke, Terrence R.; Lees, David Eric; Pohl, Lance R.

doi:10.1016/0041-008x(82)90253-8

Cited by 38 publications

(15 citation statements)

References 17 publications

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“…18 As AMCl is less toxic to microorganisms and relatively easier to be biodegraded, thus, the reduction of CAP to AMCl would have ecological significance in the elimination of the selection pressure of antibiotic for the generation of antibiotic resistant bacteria/genes in the environments. 16,45 On the other hand, HOAM and NO, the intermediates of CAP reduction in abiotic cathode BES, are toxic to microorganisms, 46 and can retain their antibacterial activity in another kind of nitroaromatic antibiotic nitroimidazoles. 47 As mentioned above, neither HOAM nor NO was detected in the biocathode BES, therefore, the biocathode is likely superior to abiotic cathode in the elimination of antibacterial activity from CAP-containing wastewaters.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Accelerated Reduction of Chlorinated Nitroaromatic Antibiotic Chloramphenicol by Biocathode

Liang

Cheng

Kong

et al. 2013

Environ. Sci. Technol.

233

117

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Chlorinated nitroaromatic antibiotic chloramphenicol (CAP) is a priority pollutant in wastewaters. A fedbatch bioelectrochemical system (BES) with biocathode with applied voltage of 0.5 V (served as extracellular electron donor) and glucose as intracellular electron donor was applied to reduce CAP to amine product (AMCl2). The biocathode BES converted 87.1 ± 4.2% of 32 mg/L CAP in 4 h, and the removal efficiency reached 96.0 ± 0.9% within 24 h. Conversely, the removal efficiency of CAP in BES with an abiotic cathode was only 73.0 ± 3.2% after 24 h. When the biocathode was disconnected (no electrochemical reaction but in the presence of microbial activities), the CAP removal rate was dropped to 62.0% of that with biocathode BES. Acetylation of one hydroxyl of CAP was noted exclusive in the biocatalyzed process, while toxic intermediates, hydroxylamino (HOAM), and nitroso (NO), from CAP reduction were observed only in the abiotic cathode BES. Electrochemical hydrodechlorination and dehalogenase were responsible for dechlorination of AMCl2 to AMCl in abiotic and microbial cathode BES, respectively. The cyclic voltammetry (CV) highlighted higher peak currents and lower overpotentials for CAP reduction at the biocathode compared with abiotic cathode. With the biocathode BES, antibacterial activity of CAP was completely removed and nitro group reduction combined with dechlorination reaction enhanced detoxication efficiency of CAP. The CAP cathodic transformation pathway was proposed based on intermediates analysis. Bacterial community analysis indicated that the dominate bacteria on the biocathode were belonging to α, β, and γ-Proteobacteria. The biocathode BES could serve as a potential treatment process for CAP-containing wastewater.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Accelerated Reduction of Chlorinated Nitroaromatic Antibiotic Chloramphenicol by Biocathode

Liang

Cheng

Kong

et al. 2013

Environ. Sci. Technol.

233

117

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“…Chloramphenicol (CAP) is a broad-spectrum antibacterial veterinary drug and has been extensively used for the treatment of infectious diseases in animals. However, it has been recognized that the CAP may cause many chronic diseases such as bone marrow depression, aplastic anemia and cardiovascular collapse [1][2][3]. As a consequence, the use of CAP in animals-derived food has been globally banned to control the food safety.…”

Section: Introductionmentioning

confidence: 99%

Green preparation of chlorine-doped graphene and its application in electrochemical sensor for chloramphenicol detection

Wang

Zhang

et al. 2019

SN Appl. Sci.

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A green but efficient synthesis approach for chlorine-doped reduced graphene oxide (Cl-RGO) was developed. The chlorine-doping and reduction was achieved in one-step by refluxing graphene oxide solution in concentrated hydrochloric acid (8 M, 120 °C) under N 2 atmosphere. X-ray photoelectron spectroscopy analysis revealed that the Cl content was 1.01 at.% in the Cl-RGO. Electrochemical measurements indicated that the Cl-RGO modified glass carbon electrode showed enhanced electrochemical conductivity and electrocatalytic activity for the veterinary drug chloramphenicol (CAP) detection. Thus a highly selective electrochemical sensor for CAP was constructed based on Cl-RGO, and a linear relationship between current intensity and CAP concentration (2-35 μM) was obtained with a detection limit of 1 μM (S/N = 3). The sensor showed excellent reproducibility, storage stability and was successfully used for CAP detection in milk, calf plasma, water and pharmaceutical samples.

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“…Keywords: Medullary aplasia, Chloramphenicol, pancytopenia. (GROSS et al, 1982;JIMENEZ et al, 1987). et al, 1988;FRAYSSINET et al, 1994…”

Section: Discussionmentioning

confidence: 99%

Aplasia Medular Correlacionada a Administraçâo do Cloranfenicol

Freitas¹,

Silva²

2016

Revista Cereus

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Introdução: Aplasia medular é uma doença rara definida por uma falência da hematopoiese e um quadro de pancitopenia. A enfermidade pode ser desencadeada por causas congênitas ou adquiridas, entre as quais podemos destacar as drogas, como o Cloranfenicol que se distingue por ser um agente mielossupressor, sobre o DNA mitocondrial, ocasionando a falha da hematopoiese. Objetivo: Descrever associações entre o Cloranfenicol e a Anemia Aplástica, tendo em vista à explanação da doença como forma de divulgação e conscientização, bem como a abordagem da associação fármaco -doença. Material e Métodos: Trata-se de um estudo de revisão bibliográfica de caráter exploratório descritivo. Foram realizadas pesquisas através de livros, artigos científicos, jornais especializados e revistas

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Bone marrow toxicity in vitro of chloramphenicol and its metabolites

Cited by 38 publications

References 17 publications

Accelerated Reduction of Chlorinated Nitroaromatic Antibiotic Chloramphenicol by Biocathode

Accelerated Reduction of Chlorinated Nitroaromatic Antibiotic Chloramphenicol by Biocathode

Green preparation of chlorine-doped graphene and its application in electrochemical sensor for chloramphenicol detection

Aplasia Medular Correlacionada a Administraçâo do Cloranfenicol

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