Bone marrow processing for transplantation using Cobe Spectra cell separator

Human bone marrow processing using a new continuous‐flow cell separation device

“…The study presented here demonstrates that the Spectra Optia can be used to effectively volume reduce and RBC deplete BM donations before transplantation. The mean volume of RBCs after processing was only 4.26 ± 1.62 mL, which is unlikely to cause a severe adverse reaction after infusion even when incompatible RBCs are present . In our study 62% of the transplants received donor‐recipient ABO‐incompatible grafts and none had adverse reactions at the time of infusion.…”

“…The mean volume of RBCs after processing was only 4.26 6 1.62 mL, which is unlikely to cause a severe adverse reaction after infusion even when incompatible RBCs are present. 5,14,15 In our study 62% of the transplants received donorrecipient ABO-incompatible grafts and none had adverse reactions at the time of infusion. The recovery of MNCs was significantly lower than the CD341 cell recovery using the Spectra Optia and is in line with previous studies 8,15 using the COBE Spectra.…”