Bone marrow MR perfusion imaging and potential for tumor evaluation

Griffith, James F.; Heijden, Rianne A. van der

doi:10.1007/s00256-022-04202-6

Cited by 4 publications

(5 citation statements)

References 88 publications

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“…Skeletal Radiol 2023;52(3):477-491.) 91 exercise therapy 14 did not result in a significant change in DCE-MRI metrics despite a decrease in pain symptoms. However, there was also no significant change in other measures of inflammation, such as synovitis.…”

Section: Osteoarthritismentioning

confidence: 83%

Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee

Mostert,

Dur,

et al. 2023

Semin Musculoskelet Radiol

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Chronic knee pain is a common condition. Causes of knee pain include trauma, inflammation, and degeneration, but in many patients the pathophysiology remains unknown. Recent developments in advanced magnetic resonance imaging (MRI) techniques and molecular imaging facilitate more in-depth research focused on the pathophysiology of chronic musculoskeletal pain and more specifically inflammation. The forthcoming new insights can help develop better targeted treatment, and some imaging techniques may even serve as imaging biomarkers for predicting and assessing treatment response in the future. This review highlights the latest developments in perfusion MRI, diffusion MRI, and molecular imaging with positron emission tomography/MRI and their application in the painful knee. The primary focus is synovial inflammation, also known as synovitis. Bone perfusion and bone metabolism are also addressed.

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Section: Osteoarthritismentioning

confidence: 83%

Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee

Mostert,

Dur,

et al. 2023

Semin Musculoskelet Radiol

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“…Empirical parameters of tissue perfusion are derived from this TIC, such as time-topeak (TTP), peak intensity (PI), and 50% wash-out intensity. CEUSderived TICs parameters, similar to dynamic contrast-enhanced MRI, show only limited ability to distinguish benign from malignant soft tissue tumors (26,27) . While 50% wash-out intensity (odds ratio (OR) 1.156, p = 0.016) and 50% washout time (OR 1.023, p = 0.0222) were independent risk factors for malignancy, the relative risk afforded is less than that of, for example, an irregular tumor margin (OR 4.490, p = 0.000) or high tumor vascularity (OR 2.307, p = 0.013) (26) .…”

Section: Additional Techniquesmentioning

confidence: 99%

Practical approach to ultrasound of soft tissue tumors and the added value of MRI: how I do it

Griffith

2023

J Ultrason

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This review outlines a practical approach to the everyday assessment of both non-neoplastic and neoplastic soft tissue tumors, focusing on ultrasound examination, though emphasizing the added benefit of magnetic resonance imaging in certain instances. Ultrasound approach and assessment, practical scenarios, report- ing, biopsy, and follow-up are covered, as well as the criteria used to distinguish benign from malignant tumors. The potential benefits and current limitations of elastography and contrast-enhanced ultrasound in assessment are also addressed. Examples of commonly encountered soft tissue tumors are shown. Ul- trasound can characterize most soft tissue masses based on their ultrasound appearance alone. Following ultrasound examination, three potential scenarios usually exist in clinical practice: (a) confident regarding diagnosis, (b) indeterminate mass with no evidence of malignancy, and (c) indeterminate mass with pos- sibility of malignancy. A diagnostic pathway for each of these scenarios is provided. Magnetic resonance imaging is generally not helpful in further characterizing masses which are indeterminate on ultrasound assessment, though it is helpful in addressing other issues such as exact tumor location and neurovascular bundle involvement that may not be fully resolved on ultrasound examination. In these situations, mag- netic resonance imaging examination can be tailored to address those specific questions that have not been adequately addressed on ultrasound examination. In this sense, both examinations are highly complemen- tary. Tips for undertaking magnetic resonance imaging examinations are provided.

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“…Studies using dynamic contrast-enhanced MRI (DCE-MRI) have shown an increased perfusion of the subchondral bone in knee OA, especially in areas with BMLs (14,15). The contrast enhancement patterns of BMLs typically involve a rapid initial contrast uptake, followed by either washout (14), progressive slow enhancement (6,7), or a potential plateau (16). These enhancement characteristics, also known as time intensity curves (TIC) (16), reflect the rate of contrast entering the arteries, passing through the BML area intravascularly or distributed into the extravascular space, and subsequent venous drainage (17), believed to correspond to neo-angiogenesis, increased cellular bone density, and altered venous drainage.…”

Section: Introductionmentioning

confidence: 99%

“…The contrast enhancement patterns of BMLs typically involve a rapid initial contrast uptake, followed by either washout (14), progressive slow enhancement (6,7), or a potential plateau (16). These enhancement characteristics, also known as time intensity curves (TIC) (16), reflect the rate of contrast entering the arteries, passing through the BML area intravascularly or distributed into the extravascular space, and subsequent venous drainage (17), believed to correspond to neo-angiogenesis, increased cellular bone density, and altered venous drainage. To our knowledge, no human studies exist comparing DCE-MRI findings with histopathological changes in BMLs.…”

Section: Introductionmentioning

confidence: 99%

Bone marrow lesions in knee osteoarthritis assessed by dynamic contrast-enhanced MRI with histopathological correlations

Nielsen,

Sørensen,

Egund

et al. 2024

Acta Radiol

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Background Bone marrow lesions (BMLs) in knee osteoarthritis (OA) have been assessed histopathologically and by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI); however, a direct comparison of the results has not been reported. Purpose To evaluate and compare the findings by DCE-MRI and histopathology of subchondral BMLs in knee OA. Material and Methods In total, 19 patients with medial tibiofemoral knee OA undergoing total knee arthroplasty were analyzed. Preoperative MRI, including a DCE sequence, was performed, and bone biopsies were obtained from the resected specimens corresponding to BML areas. The contrast enhancement by DCE-MRI was analyzed using semi-quantitative (area under the curve [AUC]), peak enhancement [PE]), and quantitative (Ktrans, Kep) methods. Enhancement in the medial OA compartment was compared with similar areas in a normal lateral compartment, and the DCE characteristics of BMLs were correlated with semi-quantitatively graded histopathological features. Results AUC and PE were significantly higher in medial tibial and femoral BMLs compared with the values in the lateral condyles; Ktrans and Kep were only significantly higher in the tibial plateau. In the tibia, AUC and PE were significantly correlated with the grade of vascular proliferation, and PE also with the degree of marrow fibrosis. There was no significant correlation between AUC/PE and histopathological findings in the femur and no correlation between quantitative DCE parameters and histopathological findings. Conclusion BML characteristics by semi-quantitative DCE in the form of AUC and PE may be used as parameters for the degree of histopathological vascularization in the bone marrow whereas quantitative DCE data were less conclusive.

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Bone marrow MR perfusion imaging and potential for tumor evaluation

Cited by 4 publications

References 88 publications

Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee

Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee

Practical approach to ultrasound of soft tissue tumors and the added value of MRI: how I do it

Bone marrow lesions in knee osteoarthritis assessed by dynamic contrast-enhanced MRI with histopathological correlations

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