Bone Marrow Mesenchymal Stem Cells as a New Therapeutic Approach for Diabetes Mellitus

Kim, Joseph W.; Luo, John Zq; Luo, Liqiang

doi:10.1016/b978-0-12-811920-4.00010-0

Cited by 3 publications

(3 citation statements)

References 94 publications

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“…They consist of five cell types (alpha, beta, delta, gamma and epsilon) that secrete hormones that regulate the metabolism of carbohydrates and lipids and control digestive system function. Most of the islets are made up of beta cells (~70%) placed in the center of the islets, while alpha (~20%) and other non-beta cells are distributed on the periphery ( Figure 2 ) [ 55 ]. The critical role in maintaining glucose homeostasis in vivo in both animals and humans involves beta and alpha cells that secrete insulin and glucagon, respectively [ 56 ].…”

Section: Effect Of Acrylamide Treatment On Islets Of Langerhans Beta-...mentioning

confidence: 99%

“…Namely, the levels of glucose, AST, ALT, ALP, cholesterol, urea, creatinine, IL-beta, IL-6 and TNF-alpha were elevated in the serum of AA-exposed diabetic rats compared to AA-treated non-diabetic rats. In addition, AA application further elevated lipid peroxidation and the NO level in the liver and kidney of diabetic rats as well as decreased the SOD activity and GSH content in the diabetic kidney [ 55 ]. Taken together, these results suggest that the administration of AA to diabetic rats worsens the metabolic profile, indicating that AA has greater deteriorating effects in the diabetic state compared to the non-diabetic state [ 64 ].…”

Section: Effect Of Acrylamide Treatment On Diabeticsmentioning

confidence: 99%

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Acrylamide and Potential Risk of Diabetes Mellitus: Effects on Human Population, Glucose Metabolism and Beta-Cell Toxicity

Filipović

Karan

Ivelja

et al. 2022

IJMS

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Diabetes mellitus is a frequent endocrine disorder characterized by hyperglycemia. Acrylamide (AA) is food contaminant formed during the high-temperature processing of food rich in carbohydrates and low in proteins. Recent human epidemiological studies have shown a potential association between AA exposure and the prevalence of diabetes in the general population. In male rats, AA treatment promoted pancreatic islet remodeling, which was determined by alpha-cell expansion and beta-cell reduction, while in female rats AA caused hyperglycemia and histopathological changes in pancreatic islets. In vitro and in vivo rodent model systems have revealed that AA induces oxidative stress in beta cells and that AA impairs glucose metabolism and the insulin signaling pathway. Animal studies have shown that diabetic rodents are more sensitive to acrylamide and that AA aggravates the diabetic state. In this review, we provide an overview of human epidemiological studies that examined the relation between AA exposure and glucose disorders. In addition, the effects of AA treatment on pancreatic islet structure, beta-cell function and glucose metabolism in animal models are comprehensively analyzed with an emphasis on sex-related responses. Furthermore, oxidative stress as a putative mechanism of AA-induced toxicity in beta cells is explored. Finally, we discuss the effects of AA on diabetics in a rodent model system.

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Section: Effect Of Acrylamide Treatment On Islets Of Langerhans Beta-...mentioning

confidence: 99%

Section: Effect Of Acrylamide Treatment On Diabeticsmentioning

confidence: 99%

Acrylamide and Potential Risk of Diabetes Mellitus: Effects on Human Population, Glucose Metabolism and Beta-Cell Toxicity

Filipović

Karan

Ivelja

et al. 2022

IJMS

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show abstract

“…Most of these studies were conducted in vivo using murine models, and its application in humans led to the discovery of its actual efficacy and associated safety 10 . Some literature has investigated the synergistic effects of growth factors with MSC therapy in managing T2DM microvascular complications 20 . Other studies on the combinatory application of different cellular types, such as hematopoietic and MSCs, were applied to type-1 diabetes mellitus (T1DM) 21 .…”

Section: Discussionmentioning

confidence: 99%

Autologous bone marrow-derived mesenchymal stem cells and endothelial progenitor cells transplantation showed potential benefits for type 2 diabetes mellitus Filipino patients: a case series

Guzman,

Apelado,

Panuelos

et al. 2024

Biomed. Res. Ther.

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Introduction: Type 2 diabetes mellitus (T2DM) is a serious metabolic disorder characterized by hyperglycemia and insulin resistance. Long-standing T2DM may lead to various macro-and microvascular complications such as diabetic nephropathy, neuropathy, and retinopathy. Currently available treatments for T2DM target high plasma glucose levels but do not address T2DM-associated complications. In this report, the therapeutic application of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) transplantation in improving diabetic blood monitoring parameters among selected T2DM patients was investigated. Methods: Five Filipino patients with T2DM diagnosed for more than five years agreed to participate in the autologous bone marrow-derived stem cell transplantation. Five milliliters (mL) per kilogram (kg) of bone marrow was collected from the patients following standard procedures, and bone marrow-derived stem cells underwent quantification, genetic typing, microbial analysis, and quality control before being infused into the patients. MSCs and EPCs were intravenously transfused into the patients once a month for 6 months. Fasting blood glucose (FBG), blood urea nitrogen (BUN), glycated hemoglobin (HbA1c), and creatinine (CREA) levels were recorded pre-and post-stem cell transplantation. Results: The findings of the study revealed that the administration of autologous bone marrow-derived stem cells showed no adverse effects and improved or controlled the blood monitoring levels in most patients. Four out of five patients showed a reduction in their BUN (mean reduction = 2.246) and HbA1c (mean reduction = 0.74%) and maintained their creatinine levels within the normal range following the 6 months of infusion. Meanwhile, three out of five patients showed a decrease in FBG levels (mean reduction = 1.484 mmol/L). Conclusion: This preliminary report suggests the potential of autologous bone marrow-derived stem cell transplantation for the treatment and management of T2DM. Future studies may focus on examining other parameters such as C-peptide levels and evaluate the efficacy and safety of autologous MSCs and EPCs in the long-term management of T2DM.

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An Insight into the Polymeric Nanoparticles Applications in Diabetes Diagnosis and Treatment

Dehghani

Rad

Zarepour

et al. 2023

MRMC

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: Diabetes mellitus (DM) is a type of chronic metabolic disease that has affected millions of people worldwide and is known with a defect in the amount of insulin secretion, insulin functions, or both. This deficiency leads to an increase in the amounts of glucose, which could be accompanied by long-term damages to other organs such as eyes, kidneys, heart, and nervous system. Thus, introducing an appropriate approach for diagnosis and treatment of different types of DM is the aim of several researches. By the emergence of nanotechnology and its application in medicine, new approaches were presented for these purposes. The object of this review article is to introduce different types of polymeric nanoparticles (PNPs), as one of the most important classes of nanoparticles, for diabetic management. To achieve this goal, at first, some of the conventional therapeutic and diagnostic methods of DM will be reviewed. Then, different types of PNPs, in two forms of natural and synthetic polymers with different properties, as a new method for DM treatment and diagnosis will be introduced. In the next section, the transport mechanisms of these types of nano-carriers across the epithelium, via paracellular and transcellular pathways will be explained. Finally, the clinical use of PNPs in the treatment and diagnosis of DM will be summarized. Based on the results of this literature review, PNPs could be considered one of the most promising methods for DM management.

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Bone Marrow Mesenchymal Stem Cells as a New Therapeutic Approach for Diabetes Mellitus

Cited by 3 publications

References 94 publications

Acrylamide and Potential Risk of Diabetes Mellitus: Effects on Human Population, Glucose Metabolism and Beta-Cell Toxicity

Acrylamide and Potential Risk of Diabetes Mellitus: Effects on Human Population, Glucose Metabolism and Beta-Cell Toxicity

Autologous bone marrow-derived mesenchymal stem cells and endothelial progenitor cells transplantation showed potential benefits for type 2 diabetes mellitus Filipino patients: a case series

An Insight into the Polymeric Nanoparticles Applications in Diabetes Diagnosis and Treatment

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