Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization

Zhang, Jiyong; Rong, Yuluo; Luo, Chunyang; Cui, Weiding

doi:10.18632/aging.104110

Cited by 112 publications

(100 citation statements)

References 37 publications

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“…These data provided evidence that BMMSC-EVs miR-136-5p can promote chondrocyte migration in vitro and inhibit cartilage degeneration in vivo, thereby inhibiting OA [ 29 ]. Zhang et al proved that BMMSC-EVs can promote the phenotypic transformation of synovial macrophages from M1 to M2, reduce synovial hyperplasia, and inflammatory cell infiltration, significantly reducing the levels of pro-inflammatory cytokines IL-1β and TNF-α [ 30 ]. Li et al found that EVs derived from BMMSC can relieve pain by eliminating abnormal CGRP-positive nerves and abnormal H-type blood vessel formation in the subchondral bone of lumbar facet joint osteoarthritis in mice.…”

Section: Therapeutic Applications Of Evs In Oamentioning

confidence: 99%

“…Besides, the expression of collagen X and runx2 decreased, while the expression of collagen II and sox9 increased. Zhang et al, 2020 [ 30 ] pBMMSC Human chondrocytes Cells treated with 1, 5, or 10 µg/mL EVs for 24 h. EVs enhanced chondrocyte migration and proliferation Zhou et al, 2020 [ 32 ] ADSC Human chondrocytes Cells treated with 1, 5 and 10 × 10 8 particles/mL EVs for 24 h. EVs enhanced the expression of anabolic marker collagen II and decreased the expression of catabolic marker MMP13 and ADAMTS5. EVs can significantly increase the autophagy level of chondrocytes partially through mTOR inhibition.…”

Section: Therapeutic Applications Of Evs In Oamentioning

confidence: 99%

“… EVs inhibit cartilage degradation and osteophyte formation during the progression of rat OA. Zhang et al, 2020 [ 30 ] BMMSC Mice were operated by resection of the lumbar 3rd–lumbar 5th (L3–L5) spinous processes along with the supraspinous and interspinous ligaments to induce instability in the lumbar spine. The mice were injected weekly till four weeks right after surgery with EVs (200 μg of EVs in 200 μL PBS) via the tail vein.…”

Section: Therapeutic Applications Of Evs In Oamentioning

confidence: 99%

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The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis

2021

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Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a tremendous burden on the health care system worldwide. Although cell therapy has made significant progress in the treatment of OA and cartilage regeneration, there are still a series of problems. Recently, more and more evidence shows that extracellular vesicles (EVs) play an important role in the progression and treatment of OA. Here, we discuss that EVs from different cell sources not only participate in OA progression, but can also be used as effective tools for the diagnosis and treatment of OA. In addition, cell pretreatment strategies and EV tissue engineering play an increasingly prominent role in the field of OA treatment. This article will systematically review the latest developments in these areas. As stated above, it may provide new insights for improving OA and cartilage regeneration.

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Section: Therapeutic Applications Of Evs In Oamentioning

confidence: 99%

Section: Therapeutic Applications Of Evs In Oamentioning

confidence: 99%

Section: Therapeutic Applications Of Evs In Oamentioning

confidence: 99%

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The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis

2021

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“…Exosomes were extracted from a variety of cell sources. Seventeen studies used human exosomes, 56–72 nine studies used murine exosomes, 73–81 one study used rabbit exosomes, 82 and two studies did not mention the cell origin 83 , 84 ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review

Ng¹,

Chai²,

Foo³

et al. 2021

IJN

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Treatment of cartilage defects such as osteoarthritis (OA) and osteochondral defect (OCD) remains a huge clinical challenge in orthopedics. OA is one of the most common chronic health conditions and is mainly characterized by the degeneration of articular cartilage, shown in the limited capacity for intrinsic repair. OCD refers to the focal defects affecting cartilage and the underlying bone. The current OA and OCD management modalities focus on symptom control and on improving joint functionality and the patient’s quality of life. Cell-based therapy has been evaluated for managing OA and OCD, and its chondroprotective efficacy is recognized mainly through paracrine action. Hence, there is growing interest in exploiting extracellular vesicles to induce cartilage regeneration. In this review, we explore the in vivo evidence of exosomes on cartilage regeneration. A total of 29 in vivo studies from the PubMed and Scopus databases were identified and analyzed. The studies reported promising results in terms of in vivo exosome delivery and uptake; improved cartilage morphological, histological, and biochemical outcomes; enhanced subchondral bone regeneration; and improved pain behavior following exosome treatment. In addition, exosome therapy is safe, as the included studies documented no significant complications. Modifying exosomal cargos further increased the cartilage and subchondral bone regeneration capacity of exosomes. We conclude that exosome administration is a potent cell-free therapy for alleviating OA and OCD. However, additional studies are needed to confirm the therapeutic potential of exosomes and to identify the standard protocol for exosome-based therapy in OA and OCD management.

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“…It is important that macrophages treated by exosomes maintain chondrogenic properties of chondrocytes. Obviously, bone marrow MSCs-derived exosomes alleviate the OA by promoting the phenotype transformation of synovial macrophages from M1 to M2 (Zhang et al, 2020).…”

Section: Effects Of Exosomes On Macrophages In Osteoarthritismentioning

confidence: 99%

The Research Progress of Exosomes in Osteoarthritis, With Particular Emphasis on the Mediating Roles of miRNAs and lncRNAs

et al. 2021

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Osteoarthritis (OA) is a kind of degenerative disease, which is caused by many factors such as aging, obesity, strain, trauma, congenital joint abnormalities, joint deformities. Exosomes are mainly derived from the invagination of intracellular lysosomes, which are released into the extracellular matrix after fusion of the outer membrane of multi vesicles with the cell membrane. Exosomes mediate intercellular communication and regulate the biological activity of receptor cells by carrying non-coding RNA, long noncoding RNAs (lncRNAs), microRNAs (miRNAs), proteins and lipids. Evidences show that exosomes are involved in the pathogenesis of OA. In view of the important roles of exosomes in OA, this paper systematically reviewed the roles of exosomes in the pathogenesis of OA, including the roles of exosomes in OA diagnosis, the regulatory mechanisms of exosomes in the pathogenesis, and the intervention roles of exosomes in the treatment of OA. Reviewing the roles of exosomes in OA will help to clarify the pathogenesis of OA and explore new diagnostic biomarkers and therapeutic targets.

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Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization

Cited by 112 publications

References 37 publications

The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis

The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis

Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review

The Research Progress of Exosomes in Osteoarthritis, With Particular Emphasis on the Mediating Roles of miRNAs and lncRNAs

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