Bone marrow imaging using STIR at 0.5 and 1.5 T

Jones, Ken; Unger, Evan C.; Granstrom, Per; Seeger, Joachim F.; Carmody, Raymond F.; Yoshino, Mark T.

doi:10.1016/0730-725x(92)90477-h

Cited by 76 publications

(36 citation statements)

References 10 publications

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“…The MR appearance of bone marrow is influenced by both composition (fat, water, minerals) and the specific imaging sequence used [1]; however, most of the MR imaging signal characteristics of marrow are dependent on the fat content [2,3]. A routine MR evaluation of bone marrow of the foot and ankle should include a T1-weighted spin-echo sequence and a fat-suppressed T2-weighted fast spin-echo or short tau inversion recovery (STIR) sequence.…”

Section: Technical Considerationsmentioning

confidence: 99%

“…Using MR imaging the continuous change of normal bone marrow composition throughout life and the varied responses of bone marrow to trauma or disease can be monitored [1].Magnetic resonance imaging characterization of location, morphology, distribution, and signal characteristics of a bone marrow abnormality enables diagnosis of a wide range of foot and ankle disorders with a high level of specificity. This pictorial review highlights applications of MR imaging of marrow disorders of the foot and ankle including traumatic and stress-related marrow changes, avascular necrosis, osteochondral defects, arthritic, and neuropathic arthropathies as well as osteomyelitis.…”

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confidence: 99%

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MR imaging of the foot and ankle: patterns of bone marrow signal abnormalities

Weishaupt

Schweitzer

2001

Eur Radiol

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IntroductionMagnetic resonance imaging has demonstrated its usefulness in assessment of normal and abnormal bone marrow. Using MR imaging the continuous change of normal bone marrow composition throughout life and the varied responses of bone marrow to trauma or disease can be monitored [1].Magnetic resonance imaging characterization of location, morphology, distribution, and signal characteristics of a bone marrow abnormality enables diagnosis of a wide range of foot and ankle disorders with a high level of specificity. This pictorial review highlights applications of MR imaging of marrow disorders of the foot and ankle including traumatic and stress-related marrow changes, avascular necrosis, osteochondral defects, arthritic, and neuropathic arthropathies as well as osteomyelitis. Technical considerationsThe MR appearance of bone marrow is influenced by both composition (fat, water, minerals) and the specific imaging sequence used [1]; however, most of the MR imaging signal characteristics of marrow are dependent on the fat content [2,3]. A routine MR evaluation of bone marrow of the foot and ankle should include a T1-weighted spin-echo sequence and a fat-suppressed T2-weighted fast spin-echo or short tau inversion recovery (STIR) sequence. Since cellular infiltration within the fatty marrow may be less conspicuous or entirely obscured on T2-weighted fast spin-echo sequences, use of some form of fat suppression is mandatory on T2-weighted fast spin-echo MR images [4,5]. The most widely used form of fat suppression is frequency-selective presaturation. With this method, however, local field inhomogeneities that arise in areas of significantly varying morphology (e.g., ankle) often result in an uneven fat suppression. The inhomogeneous fat suppres- Eur. Radiol. (2002)

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Section: Technical Considerationsmentioning

confidence: 99%

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confidence: 99%

MR imaging of the foot and ankle: patterns of bone marrow signal abnormalities

Weishaupt

Schweitzer

2001

Eur Radiol

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“…[26][27][28] Using a similar SPIO particle, Daldrup-Link and associates demonstrated signal reduction at a rate of 34.2z in bone marrow on STIR images, which was more prominent than that observed on the T1 or T2 turbo spin-echo (TSE) sequences. 13 This result seems to be consistent with our result, although there are several diŠerences in scan timing and imaging parameters between the studies.…”

Section: Discussionmentioning

confidence: 99%

Superparamagnetic Iron Oxide (SPIO) MRI Contrast Agent for Bone Marrow Imaging: Differentiating Bone Metastasis and Osteomyelitis

Fukuda

Ando

Ishikura

et al. 2006

MRMS

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Purpose: We explored appropriate scan timing for bone marrow imaging enhanced using superparamagnetic iron oxide (SPIO) and evaluated the usefulness of SPIO in diŠerentiat-ing metastasis and osteomyelitis in patients.Methods: To determine the adequate scan timing after administration of SPIO, 5 healthy subjects were examined using a 1.5T magnetic resonance (MR) imaging scanner. Sagittal images of their lumbar spines were obtained using short-TI inversion recovery (STIR) sequence before and 3, 6, 9, 24, and 48 hours after intravenous injection of 8 mmol Fe W kg SPIO (ferucarbotran). MR signal intensities (SIs) were evaluated. Based on the results, 12 patients,ˆve with bone metastasis and seven with vertebral osteomyelitis, were examined using the same procedure before and 3 hours after intravenous injection of ferucarbotran at the same dose. SIs of the bone metastases, osteomyelitis, and surrounding normal bone marrow were measured, and relative enhancement (RE) was calculated for each lesion.Results: In the healthy volunteers, maximum reduction in signal was observed 3 to 24 hours ( Pº0.05) after administration of SPIO; thereafter and up to 48 hours, the SI gradually recovered. In the patients, the RE of the bone metastases was -12.2z, which was signiˆcantly higher than that in the osteomyelitis (-35.0z, Pº.001) and normal bone marrow Pº.0005).Conclusion: Maximum suppression of signal intensity in bone marrow was seen 3 hours after injection of ferucarbotran, the point at which ferucarbotran allows diŠerentiation of bone metastasis from ostoemyelitis.

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“…STIR images characterize the yellow marrow as SI being nullified and therefore appearing black. The T1 and T2 contrast of tissues other than fat is additive, and contrast sensitivity is thus greatly enhanced (3,17,18). Because the fat signal is highlighted on T1WI, whereas the cellular portion is emphasized on STIR images, one (patient No.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging of the Bone Marrow After Bone Marrow Transplantation or Immunosuppressive Therapy in Aplastic Anemia

et al. 2001

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To compare magnetic resonance (MR) images of the bone marrow (BM) after bone marrow transplantation or immunosuppressive therapy in patients with aplastic anemia (AA), MR imaging of BM was reviewed retrospectively in 16 patients (13 males and 3 females, mean age 26 yr) with AA who completely responded clinically after transplantation or immunosuppressive therapy. The signal intensity (SI) of BM was classified into four patterns according to the increasing amount of cellular marrow, i.e., pattern I to IV. SI of MR imaging of BM exhibited an increase of cellular marrows following both transplantation and immunosuppressive therapy. Of the eight patients on transplantation, the SI of the lumbar spinal BM was pattern III in two patients and IV in six on T1-weighted and short tau inversion recovery (STIR) images. In the eight patients with immunosuppressive therapy, the SI of the lumbar spinal BM was pattern II in one, III in five, and IV in two on T1-weighted images and pattern II in one, III in four, and IV in three on STIR images. SI on MR imaging of the lumbar spinal BM showed a more cellular pattern in patients on transplantation than in those on immunosuppressive therapy.

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Bone marrow imaging using STIR at 0.5 and 1.5 T

Cited by 76 publications

References 10 publications

MR imaging of the foot and ankle: patterns of bone marrow signal abnormalities

MR imaging of the foot and ankle: patterns of bone marrow signal abnormalities

Superparamagnetic Iron Oxide (SPIO) MRI Contrast Agent for Bone Marrow Imaging: Differentiating Bone Metastasis and Osteomyelitis

Magnetic Resonance Imaging of the Bone Marrow After Bone Marrow Transplantation or Immunosuppressive Therapy in Aplastic Anemia

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