Bone marrow-derived progenitor cells contribute to lung remodelling after myocardial infarction

Dupuis, Jocelyn; Prefontaine, Annick; Villeneuve, Louis; Ruel, Nathalie; Lefèbvre, Frédéric; Calderone, Angelino

doi:10.1016/j.carpath.2007.04.006

Cited by 16 publications

(12 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These tissue stem/progenitor cells are able to migrate towards local injury sites, where they proliferate and differentiated as needed to replace damaged tissue [13, 14]. Unlike MSCs, which are able to differentiate into multiple tissue types in different organ systems, tissue progenitor/stem cells are typically only capable of generating limited tissue types for local tissue regeneration, especially the tissue of their origin.…”

Section: Introductionmentioning

confidence: 99%

Single cell sorting identifies progenitor cell population from full thickness bovine articular cartilage

Zhang

Buckwalter

et al. 2014

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

Objective To date, no approved clinical intervention successfully prevents the progressive degradation of injured articular cartilage that leads to osteoarthritis (OA). Stem/progenitor cell populations within tissues of diarthrodial joint have shown their therapeutic potential in treating OA. However, this potential has not been fully realized due in part to the heterogeneity of these subpopulations. Characterization of clonal populations derived from a single cell may help identify more homogenous stem/progenitor populations within articular cartilage. Moreover, chondrogenic potential of clonal populations from different zones could be further examined to elucidate their differential roles in maintaining articular cartilage homeostasis. Method We combined FACS (Fluorescence-activated cell sorting) and clonogenicity screening to identify stem/progenitor cells cloned from single cells. High-efficiency colony-forming cells (HCCs) were isolated, and evaluated for stem/progenitor cell characteristics. HCCs were also isolated from different zones of articular cartilage. Their function was compared by lineage-specific gene expression, and differentiation potential. Results A difference in colony-forming efficiency was observed in terms of colony sizes. HCCs were highly clonogenic and multipotent, and overexpressed stem/progenitor cell markers. Also, proliferation and migration associated genes were over-expressed in HCCs. HCCs showed zonal differences with deep HCCs more chondrogenic and osteogenic than superficial HCCs. Conclusion Our approach is a simple yet practical way to identify homogeneous stem/progenitor cell populations with clonal origin. The discovery of progenitor cells demonstrates the intrinsic self-repairing potential of articular cartilage. Differences in differentiation potential may represent the distinct roles of superficial and deep zone stem/progenitor cells in the maintenance of articular cartilage homeostasis.

show abstract

Section: Introductionmentioning

confidence: 99%

Single cell sorting identifies progenitor cell population from full thickness bovine articular cartilage

Zhang

Buckwalter

et al. 2014

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

“…Furthermore, neoplastic prostatic epithelial cells may be able to acquire the ability to assume a fibroblastic phenotype by undergoing EMT, similar to that demonstrated in breast cancer biopsy tissues (Petersen et al, 2003). Another alternative mechanism might be that loss of epithelial and stromal differentiation in the prostate leads to the recruitment of bone marrow‐derived cells that subsequently take up residence and differentiate into myofibroblasts in the stroma (Lincoln et al, 1997; Brittan et al, 2002, 2005; Direkze et al, 2003; Hashimoto et al, 2004; Hayashida et al, 2005; Jabs et al, 2005; Mori et al, 2005; Yamaguchi et al, 2005; Haudek et al, 2006; Asawa et al, 2007; Bellini and Mattoli, 2007; Dupuis et al, 2007; Li et al, 2007; Morimoto et al, 2007).…”

Section: Stromal–epithelial Interactions In Primary Prostate Cancermentioning

confidence: 99%

Gene Targeting to the Stroma of the Prostate and Bone

2008

View full text Add to dashboard Cite

Stromal-epithelial interactions mediated by paracrine signaling mechanisms dictate prostate development and progression of prostate cancer. The regulatory role of androgens in both the prostate stromal and epithelial compartments set the prostate apart from many other organs and tissues with regard to gene targeting. The identification of androgen-dependent prostate epithelial promoters has allowed successful gene targeting to the prostate epithelial compartment. Currently, there are no transgenic mouse models available to specifically alter gene expression within the prostate stromal compartment. As a primary metastatic site for prostate cancer is bone, the functional dissection of the bone stromal compartment is important for understanding stromal-epithelial interactions associated with metastatic tumor growth. Use of currently available methodologies for the expression or deletion of gene expression in recent research studies has advanced our understanding of the stroma. However, the complexity of stromal heterogeneity within the prostate remains a challenge to obtaining compartment or cell-lineage-specific in vivo models necessary for furthering our understanding of prostatic developmental, benign, tumorigenic, and metastatic growth.

show abstract

“…Effects of bosentan on PH, and RV and LV remodeling and function MF proliferation and excessive collagen deposition in the lung contribute to the development of secondary PH and RVH [3,26]. Although bosentan has demonstrated its capacity to improve chronic PAH of various aetiologies, its effectiveness in PH associated with left heart disease has not been specifically tested.…”

Section: Effects Of Bosentan On Lung Structural Remodeling and Functionmentioning

confidence: 99%

“…The repair process in response to lung injury is characterised by the proliferation of MFs that can originate from resident lung cells or marrow-derived cells [14,25,26]. These cells are important modulators of lung fibrotic disorders and also play an important role in lung structural remodeling associated with HF [3].…”

Section: Effects Of Bosentan On Lung Structural Remodeling and Functionmentioning

confidence: 99%

Bosentan does not improve pulmonary hypertension and lung remodeling in heart failure

Jiang

Jc²,

Shi³

et al. 2010

Eur Respir J

View full text Add to dashboard Cite

Pulmonary hypertension (PH) and right ventricular (RV) dysfunction associated with heart failure (HF) carry a poor prognosis. Although endothelin receptor antagonists (ERAs) demonstrated benefits in pulmonary arterial hypertension, their efficacy in PH associated with HF was not specifically evaluated.2 weeks after myocardial infarction (MI) rats received bosentan (100 or 200 mg?kg -1 ?day -1 ) or no treatment for 3 weeks. PH, RV hypertrophy and function as well as lung remodeling and function were evaluated. LV echocardiographic wall motion abnormality and function measured before treatment (2 weeks after MI) and after treatment (5 weeks after MI) were similar in MI control and MI treatment groups. HF induced PH and RV hypertrophy compared with sham: RV systolic pressure 39¡5 versus 23¡0.8 mmHg and RV/left ventricular+septum weight 52¡7 versus 24¡0.5% (all p,0.01). Bosentan did not significantly modify these parameters. In addition, bosentan did not improve depressed RV function measured by echocardiograph from the RV myocardial performance index and tricuspid annular plane systolic excursion. The respiratory pressurevolume relationship revealed that HF caused a restrictive lung syndrome with histological lung remodeling and fibrosis, also not improved by bosentan.Dual ERA therapy with bosentan does not reduce PH, RV hypertrophy and lung remodeling and dysfunction associated with ischaemic HF.

show abstract

Bone marrow-derived progenitor cells contribute to lung remodelling after myocardial infarction

Cited by 16 publications

References 27 publications

Single cell sorting identifies progenitor cell population from full thickness bovine articular cartilage

Single cell sorting identifies progenitor cell population from full thickness bovine articular cartilage

Gene Targeting to the Stroma of the Prostate and Bone

Bosentan does not improve pulmonary hypertension and lung remodeling in heart failure

Contact Info

Product

Resources

About