Bone marrow-derived pancreatic stellate cells in rats

Simultaneous characterization of pancreatic stellate cells and other pancreatic components within three-dimensional tissue environment during chronic pancreatitis

“…8(d) and 8(f)], which is possibly from a bone-marrow origin. 38 It can be seen from the above results that the fluorescence from vitamin A enables morphological characterization of PSCs within 3-D tissue structure before they become activated. After the loss of vitamin A in the cell, the TPEF intensity of PSCs in the red channel decreased.…”

StellaTUM: current consensus and discussion on pancreatic stellate cell research

“…In 2006, it was reported that BM is a source of myofibroblast-like cells in fibrotic liver tissue, but the involvement of these cells in the progression of liver fibrosis remains questionable as their contribution to collagen synthesis appears to be limited 19 20. Recent studies have now also addressed the role of BM-derived cells in pancreatic regeneration and fibrosis 21 22. Using a similar experimental approach, namely the transfer of green fluorescent protein (GFP)-expressing BM cells to lethally irradiated small rodents followed by the induction of chronic pancreatitis with cerulein or dibutyltin dichloride, it was consistently shown that BM-derived cells did home to the pancreas 21 22.…”

Tumor-stromal interactions in pancreatic cancer

“…Two recent studies have suggested that a small proportion (5e18%) of the proliferative PSC population in the pancreas could have originated in the bone marrow [28,29]. Additional studies are needed to investigate this further.…”