Bone Marrow Changes in Anorexia Nervosa Are Correlated With the Amount of Weight Loss and Not With Other Clinical Findings

Abstract

We describe a retrospective study of 4 cases of sporadic fatal infectious mononucleosis (IM), 1 case of fatal IM, and 1 case of sporadic severe IM. Patients were 26 months to 17 years old; 3 were male. Five died of complications of IM. All 5 of these patients had the Epstein-Barr virus (EBV) present in examined tissue specimens; EBV was monoclonal in 3 patients and biclonal in 1. EBV clonality studies were not performed in the remaining patient. All 5 patients also had monoclonal gene rearrangements. The sixth patient survived despite a life-threatening clinical course; EBV was oligoclonal, and gene rearrangements were not detected. EBV clonality and gene rearrangement studies may be usefulfor predicting which patients with clinically aggressive IM are at highest risk for fatal outcome. Patients in whom IM has a fatal outcome are more likely to have monoclonal or biclonal EBV and immunoglobulin heavy chain or T-cell receptor gene rearrangements. In contrast, patients with nonfatal IM may lack monoclonal EBV and monoclonal rearrangements of the aforementioned genes. The reasons EBV induces a monoclonal proliferation only in some patients remain to be elucidated.

Heterogeneity of adipose tissue in development and metabolic function

“…In contrast to IMAT and pancreatic adipocytes, the amount of BMAT does not correlate with total body fat (Di Iorgi et al, 2008;Hardouin et al, 2016;Justesen et al, 2001;Shen et al, 2007), even though a positive correlation between visceral adiposity and vertebral BMAT has been reported for obese premenopausal women (Bredella et al, 2011). Moreover, BMAT is not catabolized during acute starvation but increases during conditions of prolonged caloric restriction, including anorexia nervosa (Abella et al, 2002;Bredella et al, 2009;Cawthorn et al, 2016;Devlin et al, 2010;Ecklund et al, 2010;Moyer-Mileur et al, 2008). The metabolic role of BMAT is not well understood; however, aging-associated increases in BMAT result in reduced bone mineral density (Griffith et al, 2012;Kugel et al, 2001).…”

A case of unusual etiology for thrombocytopenia in a young male

“…In four large retrospective studies, incidence of leukopenia ranged from 22% to 36%, anemia from 21% to 39%, and thrombocytopenia from 5% to 11.3% [3][4][5][6][7][8] . The cumulative incidence of bipenias or pancytopenia is unclear.…”

“…Chen et al described a 12-year-old female with AN and complete serous atrophy of her bone marrow but interestingly, no significant peripheral cytopenias [15] . Abella et al reported that often the bone marrow changes are not correlated with peripheral counts [6] . Our patient's peripheral cell counts were much higher than would be expected with a 10% hypocellular marrow with significant serous atrophy.…”

Cause rare d’hypoplasie sévère: la transformation gélatineuse de la moelle osseuse

“…Une anémie arégénérative, normochrome et normocytaire doit faire envisager la pratique d'un myélogramme et si celui-ci n'est pas contributif, la réalisation d'une biopsie ostéomédullaire [7].…”