Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis

Eisenstein, Anna; Chitalia, Shlok V.; Ravid, Katya

doi:10.3390/ijms21207470

Cited by 19 publications

(15 citation statements)

References 94 publications

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“…29,30 In adipocytes, adenosine could inhibit lipolysis as mediated by adenosine receptors. 31 Accordingly, ADORA2A inhibition might trigger lipolysis in adipocytes and lead to a body fat and body weight reduction.…”

Section: Discussionmentioning

confidence: 99%

A Food Supplement with Antioxidative Santa Herba Extract Modulates Energy Metabolism and Contributes to Weight Management

Mödinger

Schön

Wilhelm

et al. 2021

Journal of Medicinal Food

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The plant Santa herba (Eriodictyon californicum) contains high flavonoids, thus potentially exerting beneficial effects in context of obesity, often accompanied by inflammation and metabolic imbalance. The study assessed the impact of Santa herba on oxidative stress, energy metabolism, weight reduction, and eating behavior, combining in vitro models with clinical data. Santa herba binding of the adenosine receptor A2A (ADORA2A) was assessed using a radioligand binding assay. A Caenorhabditis elegans model was used to determine mobility boosting effects, and Santa herba oxygen radical absorbance capacity (ORAC) values were determined in comparison to antioxidative plants. Clinical data, that is, body weight and appetite-related parameters, were obtained from overweight and obese women receiving either Santa herba or placebo for 12 weeks. Results showed that Santa herba extract binds to ADORA2A, stimulates C. elegans motility (+7.5%) and locomotion, and yields high antioxidative capacities (ORAC: 819 trolox equivalent). Clinical data, obtained from 24 overweight and 25 obese women (mean: 47.5 years), demonstrated a reduced body weight (P = .042) and body fat (P = .044), and by trend reduced leptin levels (P = .065) in women with obesity after Santa herba consumption compared to placebo. In conclusion, Santa herba extract has energizing and antioxidative properties and may aid in weight management of people with obesity. ClinicalTrials.gov Identifier: NCT03853603.

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Section: Discussionmentioning

confidence: 99%

A Food Supplement with Antioxidative Santa Herba Extract Modulates Energy Metabolism and Contributes to Weight Management

Mödinger

Schön

Wilhelm

et al. 2021

Journal of Medicinal Food

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“…Adenosine downstream signaling is mediated via a set of P1 adenosine receptors (A1R, A2AR, A2BR, and A3R), which initiate G protein-coupled signaling and modulation of AC activity [ 97 , 118 ]. Adenosine receptors modulate cAMP production with differential effects, as A1R and A3R inhibit, whereas A2AR and A2BR enhance, cAMP production [ 95 , 119 ]. However, phosphorylation cascades downstream cAMP production may again converge into ERK1/2 activation and this may be stimulatory with all four receptors [ 95 ].…”

Section: The Molecular Role Of Tnap In Inflammation Processesmentioning

confidence: 99%

“…The dark side of these effects, if chronically sustained, may be the support of immunosuppression and eventually the susceptibility to develop cancer [ 95 ]. Adenosine receptors are expressed in cells of the bone marrow and show effects on osteo- and adipogenesis [ 119 ]. Similar effects have been reported in other organs, such as liver and kidney [ 120 , 121 ].…”

Section: The Molecular Role Of Tnap In Inflammation Processesmentioning

confidence: 99%

TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism

Graser

Liedtke

Jakob

2021

IJMS

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This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here.

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“…In parallel, there are effects promoted by ADO, the receptors of which have been found in bone cells [ 28 ]. More in detail, all ADO receptors (AR) are present in the osteoblast precursors, that is the MSCs of both rat and human bone marrow, albeit with different levels of expression [ 29 , 30 , 31 ].…”

Section: Brief Overview On the Activity Of Purines And Related Receptors In Bone Functionmentioning

confidence: 99%

In Search of a Role for Extracellular Purine Enzymes in Bone Function

et al. 2021

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Bone is one of the major tissues that undergoes continuous remodeling throughout life, thus ensuring both organic body growth during development and protection of internal organs as well as repair of trauma during adulthood. Many endogenous substances contribute to bone homeostasis, including purines. Their role has increasingly emerged in recent decades as compounds which, by interacting with specific receptors, can help determine adequate responses of bone cells to physiological or pathological stimuli. Equally, it is recognized that the activity of purines is closely dependent on their interconversion or metabolic degradation ensured by a series of enzymes present at extracellular level as predominantly bound to the cell membrane or, also, as soluble isoforms. While the effects of purines mediated by their receptor interactions have sufficiently, even though not entirely, been characterized in many tissues including bone, those promoted by the extracellular enzymes providing for purine metabolism have not been. In this review, we will try to circumstantiate the presence and the role of these enzymes in bone to define their close relationship with purine activities in maintaining bone homeostasis in normal or pathological conditions.

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Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis

Cited by 19 publications

References 94 publications

A Food Supplement with Antioxidative Santa Herba Extract Modulates Energy Metabolism and Contributes to Weight Management

A Food Supplement with Antioxidative Santa Herba Extract Modulates Energy Metabolism and Contributes to Weight Management

TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism

In Search of a Role for Extracellular Purine Enzymes in Bone Function

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